Characterization of anandamide-induced tolerance: comparison to Δ9-THC-induced interactions with dynorphinergic systems

A simplified method of evaluating dose-effect experiments.

1948 • 7,047 citations

A Multiple Comparison Procedure for Comparing Several Treatments with a Control

1955 • 5,730 citations

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

1992 • 5,504 citations

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

1941 • 3,174 citations

Intrathecal morphine in mice: A new technique

1980 • 1,880 citations

A Multiple Comparison Procedure for Comparing Several Treatments with a Control

1955 • 1,399 citations

Dynorphin Is a Specific Endogenous Ligand of the κ Opioid Receptor

1982 • 1,160 citations

Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands.

1996 • 555 citations

Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction.

1993 • 469 citations

Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent

1993 • 453 citations

The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice.

1994 • 383 citations

Anandamide, an endogenous cannabinoid, inhibits calcium currents as a partial agonist in N18 neuroblastoma cells

1993 • 356 citations

Narcotic antagonists in the benzomorphan series

1964 • 323 citations

Spinal and supraspinal components of cannabinoid-induced antinociception.

1991 • 214 citations

Antinociceptive activity of intrathecally administered cannabinoids alone, and in combination with morphine, in mice.

1992 • 197 citations

Pharmacological characterization of substance P-induced nociception in mice: modulation by opioid and noradrenergic agonists at the spinal level.

1983 • 193 citations

Opioid Peptide Processing and Receptor Selectivity

1986 • 189 citations

Physical withdrawal in rats tolerant to Δ9-tetrahydrocannabinol precipitated by a cannabinoid receptor antagonist

1995 • 170 citations

Search for endogenous ligands of the cannabinoid receptor

1994 • 132 citations

Development of cross-tolerance between delta 9-tetrahydrocannabinol, CP 55,940 and WIN 55,212.

1994 • 125 citations

Interactions between delta 9-tetrahydrocannabinol and kappa opioids in mice.

1994 • 125 citations

Modulation of cannabinoid-induced antinociception after intracerebroventricular versus intrathecal administration to mice: possible mechanisms for interaction with morphine.

1995 • 120 citations

The role of endogenous opioids in enhancing the antinociception produced by the combination of delta 9-tetrahydrocannabinol and morphine in the spinal cord.

1996 • 116 citations

Cannabinoid-induced antinociception is mediated by a spinalα2-noradrenergic mechanism

1991 • 113 citations

Cross‐tolerance between delta‐9‐tetrahydrocannabinol and the cannabimimetic agents, CP 55,940, WIN 55,212‐2 and anandamide

1993 • 107 citations

The Antinociceptive Effects of Intrathecally Administered Levonantradol and Desacetyllevonantradol in the Rat

1981 • 102 citations

Blockade of cannabinoid-induced antinociception by norbinaltorphimine, but not N,N-diallyl-tyrosine-Aib-phenylalanine-leucine, ICI 174,864 or naloxone in mice.

1993 • 80 citations

Characterization of anandamide- and fluoroanandamide-induced antinociception and cross-tolerance to delta 9-THC after intrathecal administration to mice: blockade of delta 9-THC-induced antinociception.

1995 • 78 citations

Involvement of dynorphin B in the antinociceptive effects of the cannabinoid CP55,940 in the spinal cord.

1997 • 77 citations

Low doses of anandamides inhibit pharmacological effects of delta 9-tetrahydrocannabinol.

1995 • 74 citations

Anandamides: tolerance and cross-tolerance toΔ9-tetrahydrocannabinol

1995 • 66 citations

Effects of two endogenous fatty acid ethanolamides on mouse vasa deferentia

1994 • 57 citations

Processing of prodynorphin-derived peptides in striatal extracts. Identification by electrospray ionization mass spectrometry linked to size-exclusion chromatography

1995 • 46 citations

Antisense oligodeoxynucleotides to the κ-1 receptor block the antinociceptive effects of Δ9-THC in the spinal cord

1995 • 32 citations

Spinal involvement of both dynorphin A and Met-enkephalin in the antinociception induced by intracerebroventricularly administered bremazocine but not morphine in the mouse.

1993 • 32 citations

Formation of [Leu⁵]Enkephalin from Dynorphin A(1–8) by Rat Central Nervous Tissue In Vitro

1990 • 25 citations

Involvement of spinal kappa opiod receptors in the antagonistic effect of dynorphins on morphine antinociception

1991 • 22 citations

Both dynorphin A(1-17) and [Des-Tyr1]dynorphin A(2-17) inhibit adenylyl cyclase activity in rat caudate putamen.

1996 • 19 citations

Agonist and antagonist effects of dynorphin A-(1-13) in a thermal antinociception assay in rhesus monkeys.

1995 • 19 citations