Involvement of spinal kappa opiod receptors in the antagonistic effect of dynorphins on morphine antinociception

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

1941 • 3,174 citations

Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry

1984 • 2,580 citations

Intrathecal morphine in mice: A new technique

1980 • 1,880 citations

Dynorphin Is a Specific Endogenous Ligand of the κ Opioid Receptor

1982 • 1,160 citations

Statistical Method in Biological Assay.

1966 • 820 citations

Pharmacology of opioids.

1983 • 627 citations

Naltrindole, a highly selective and potent non-peptide δ opioid receptor antagonist

1988 • 599 citations

Dynorphin1–8 and dynorphin1–9 are ligands for the κ-subtype of opiate receptor

1982 • 448 citations

Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.

1988 • 399 citations

Predominance of the amino-terminal octapeptide fragment of dynorphin in rat brain regions

1982 • 235 citations

Differential effects of leucine and methionine enkephalin on morphine-induced analgesia, acute tolerance and dependence.

1979 • 191 citations

Antinociception and paralysis induced by intrathecal dynorphin A.

1985 • 164 citations

Dynorphin A and related peptides administered intrathecally in the rat: a search for putative kappa opiate receptor activity.

1986 • 157 citations

Dynorphin: Potent analgesic effect in spinal cord of the rat

1982 • 110 citations

The increased efficacy of narcotic antagonists induced by various narcotic analgesics.

1974 • 105 citations

Analgesic activity of intraspinally administered dynorphin and ethylketocyclazocine

1982 • 71 citations

Intrathecally administered dynorphin-(1–17) modulates morphine-induced antinociception differently in morphine-naive and morphine-tolerant rats

1987 • 62 citations

Stereochemical studies on medicinal agents. 31. Only one pharmacophore is required for the .kappa. opioid antagonist selectivity of norbinaltorphimine

1988 • 47 citations

Dynorphin-A-(1–13) antagonizes morphine analgesia in the brain and potentiates morphine analgesia in the spinal cord

1985 • 45 citations

Comparative spinal analgesic action of dynorphin_1-8, dynorphin_1-13, and a kappa-receptor agonist U50,488

1986 • 44 citations

Dynorphin1–13: interaction with other opiate ligand bindings in vitro

1984 • 24 citations

Studies in vivo with dynorphin-(1–9): Analgesia but not gastrointestinal effects following intrathecal administration to mice

1983 • 23 citations

Systemic single dose morphine pretreatment desensitizes mice to the spinal antianalgesic action of dynorphin A (1-17).

1990 • 22 citations

Vasoactive intestinal peptide: Expression of the prohormone in bacterial cells

1985 • 15 citations