Binding of the h-ras p21 GTPase activating protein by the activated epidermal growth factor receptor leads to inhibition of the p21 GTPase activity in vitro

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Oncogenes and signal transduction

1991 • 2,816 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Epidermal growth factor.

1990 • 1,645 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21

1990 • 984 citations

Stimulation of p21ras upon T-cell activation

1990 • 882 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

Autophosphorylation sites on the epidermal growth factor receptor

1984 • 730 citations

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

1990 • 684 citations

Cloning of bovine GAP and its interaction with oncogenic ras p21

1988 • 666 citations

Binding of SH2 Domains of Phospholipase Cγ1, GAP, and Src to Activated Growth Factor Receptors

1990 • 608 citations

PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

1990 • 561 citations

Src homology region 2 domains direct protein-protein interactions in signal transduction.

1990 • 498 citations

PDGF induction of tyrosine phosphorylation of GTPase activating protein

1989 • 478 citations

Binding of GAP to Activated PDGF Receptors

1990 • 396 citations

Differential regulation of rasGAP and neurofibromatosis gene product activities

1991 • 338 citations

Signalling by the sevenless protein tyrosine kinase is mimicked by Rasl activation

1992 • 315 citations

The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.

1990 • 314 citations

Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)

1990 • 305 citations

Expression of p21 proteins in Escherichia coli and stereochemistry of the nucleotide-binding site.

1986 • 287 citations

The Effect of GTPase Activating Protein Upon Ras Is Inhibited by Mitogenically Responsive Lipids

1989 • 287 citations

Platelet-derived growth factor stimulates formation of active p21ras.GTP complex in Swiss mouse 3T3 cells.

1990 • 282 citations

Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein.

1991 • 279 citations

Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity.

1990 • 264 citations

The Son of sevenless Gene Product: a Putative Activator of Ras

1992 • 263 citations

A Cytosolic Protein Catalyzes the Release of GDP from p21 ^ras

1990 • 231 citations

All Autophosphorylation Sites of Epidermal Growth Factor (EGF) Receptor and HER2/neu Are Located in Their Carboxyl-terminal Tails

1989 • 213 citations

Relationship Among Guanine Nucleotide Exchange, GTP Hydrolysis, and Transforming Potential of Mutated ras Proteins

1988 • 196 citations

ras and GAP—Who's controlling whom?

1990 • 185 citations

The biochemistry of ras p21

1991 • 176 citations

Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor.

1990 • 167 citations

A C-terminal domain of GAP is sufficient to stimulate ras p21 GTPase activity.

1989 • 161 citations

Enhancement of the GDP-GTP Exchange of RAS Proteins by the Carboxyl-Terminal Domain of SCD25

1990 • 152 citations

A novel membrane factor stimulates guanine nucleotide exchange reaction of ras proteins

1990 • 119 citations

Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein.

1991 • 88 citations

Transphosphorylation as a possible mechanism for insulin and epidermal growth factor receptor activation.

1990 • 80 citations

How does p21ras transform cells?

1991 • 75 citations

The world according to GAP.

1990 • 72 citations

Purification, characterization, and western blot analysis of human GTPase-activating protein from native and recombinant sources.

1990 • 69 citations

Inhibition by phospholipids of the interaction between R-ras, rho, and their GTPase-activating proteins.

1989 • 66 citations

Regulation of p21ras activity

1991 • 60 citations

SH2 domains: elements that control protein interactions during signal transduction

1991 • 43 citations

[7] Purification of functionally active epidermal growth factor receptor protein using a competitive antagonist monoclonal antibody and competitive elution with epidermal growth factor

1987 • 22 citations

Closing the GAP in a signal transduction pathway

1990 • 19 citations