Calcium out of control

The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs.

1977 • 1,927 citations

The “No-Reflow” Phenomenon after Temporary Coronary Occlusion in the Dog

1974 • 1,804 citations

Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog.

1983 • 1,168 citations

A further Contribution regarding the influence of the different Constituents of the Blood on the Contraction of the Heart

1883 • 941 citations

An infarct-like myocardial lesion and other toxic manifestations produced by isoproterenol in the rat.

1959 • 676 citations

Lipid-membrane interactions and the pathogenesis of ischemic damage in the myocardium.

1981 • 607 citations

Role of oxygen in the cellular damage induced by re-oxygenation of hypoxic heart

1980 • 550 citations

Kinetics of calcium accumulation in acute myocardial ischemic injury.

1972 • 507 citations

MITOCHONDRIAL CALCIUM OVERLOAD: A GENERAL MECHANISM FOR CELL-NECROSIS IN MUSCLE DISEASES

1976 • 494 citations

The oxygen paradox and the calcium paradox: Two facets of the same problem?

1978 • 491 citations

Paradoxical Influence of Calcium Ions on the Permeability of the Cell Membranes of the Isolated Rat Heart

1966 • 479 citations

Reperfusion of the ischemic myocardium

1977 • 469 citations

Lethal myocardial ischemic injury.

1981 • 451 citations

Relation between high energy phosphate and lethal injury in myocardial ischemia in the dog.

1978 • 417 citations

The pathophysiology of superoxide: roles in inflammation and ischemia

1982 • 368 citations

Prolonged depletion of ATP and of the adenine nucleotide pool due to delayed resynthesis of adenine nucleotides following reversible myocardial ischemic injury in dogs

1981 • 359 citations

Effect of a transient period of ischemia on myocardial cells. I. Effects on cell volume regulation.

1974 • 356 citations

Ischemic tissue injury.

1975 • 336 citations

Calcium Flux and Contractility in Guinea Pig Atria

1962 • 325 citations

Myocardial contracture and accumulation of mitochondrial calcium in ischemic rabbit heart

1977 • 296 citations

Changes in energy state and acid-base parameters of the rat brain during complete compression ischemia

1974 • 293 citations

Tissue osmolality, cell swelling, and reperfusion in acute regional myocardial ischemia in the isolated porcine heart.

1981 • 264 citations

Myocardial fiber necrosis due to intracellular Ca overload-a new principle in cardiac pathophysiology.

1974 • 212 citations

Intracellular calcium concentration during hypoxia and metabolic inhibition in mammalian ventricular muscle.

1983 • 211 citations

The effects of verapamil, quiescence, and cardioplegia on calcium exchange and mechanical function in ischemic rabbit myocardium.

1982 • 202 citations

Decoupling of heart muscle cells: Correlation with increased cytoplasmic calcium activity and with changes of nexus ultrastructure

1980 • 199 citations

Proton and free oxygen radical interaction with the calcium transport system of cardiac sarcoplasmic reticulum

1981 • 179 citations

A protective effect of verapamil on hypoxic heart muscle

1976 • 175 citations

Heterogeneity of the hypoxic state in perfused rat heart.

1977 • 160 citations

THE EFFECTS OF VARIOUS DRUGS ON CALCIUM EXCHANGE IN THE ISOLATED GUINEA-PIG LEFT AURICLE.

1964 • 157 citations

A relationship between adenosine triphosphate, glycolysis and ischaemic contracture in the isolated rat heart

1981 • 151 citations

Effects of ischaemia and reperfusion on calcium exchange and mechanical function in isolated rabbit myocardium

1981 • 138 citations

Calcium uptake during post-ischemic reperfusion in the isolated rat heart: Influence of extracellular sodium

1982 • 127 citations

Oxygen-induced enzyme release: Early events and a proposed mechanism

1979 • 120 citations

Spin label studies on rat liver and heart plasma membranes: Effects of temperature, calcium, and lanthanum on membrane fluidity

1978 • 118 citations

Disturbed myocardial calcium metabolism: a possible pathogenetic factor in the hereditary cardiomyopathy of the Syrian hamster.

1975 • 117 citations

The protective effect of hyperosmotic mannitol in myocardial ischemia and necrosis.

1976 • 115 citations

Enzyme release during myocardial anoxia: A study of metabolic protection

1975 • 110 citations

Lysosomal alterations in ischemic myocardium: Result or cause of myocellular damage?

1978 • 104 citations

Aetiology and Pathophysiology of Malignant Hyperthermia

1987 • 98 citations

The relationship of ischemic contracture to vascular reperfusion in the isolated rat heart

1980 • 92 citations

Calcium, strontium, and barium movements during ischemia and reperfusion in rabbit ventricle. Implications for myocardial preservation.

1978 • 89 citations

Kinetic localization of contractile calcium in rabbit myocardium

1971 • 89 citations

Low calcium reperfusion of ischemic myocardium

1983 • 81 citations

Prevention of Hereditary Cardiomyopathy in the Hamster by Verapamil and Other Agents

1975 • 77 citations

Key role of Ca in the production of noncoronarogenic myocardial necroses.

1975 • 75 citations

ECS, intracellular pH, and electrolytes of cardiac and skeletal muscle

1975 • 75 citations

Relaxation in heart muscle: some morphological and biochemical considerations.

1978 • 74 citations

The effect of -adrenoceptor and Ca2+ antagonist drugs on the hypoxia-induced increase in resting tension

1978 • 69 citations

Loss of canine myocardial nicotinamide adenine dinucleotides determines the transition from reversible to irreversible ischemic damage of myocardial cells

1981 • 67 citations

Lanthanum Probe Studies of Cellular Pathophysiology Induced by Hypoxia in Isolated Cardiac Muscle

1977 • 64 citations

Mechanism of tissue Ca2+ gain during reoxygenation after hypoxia in rabbit myocardium

1982 • 56 citations

Calcium exchange in rabbit myocardium during and after hypoxia: effect of temperature and substrate

1980 • 56 citations

Heat production during hypoxic contracture of rat myocardium.

1982 • 51 citations

Calcium Ions, Hormones and Mitochondrial Metabolism

1981 • 47 citations

Intracellular calcium and myocardial contractility IV. Distribution of calcium in the failing heart

1972 • 42 citations

Oxygen-induced enzyme release. Assessment of mitochondrial function in anoxic myocardial injury and effects of the mitochondrial uncoupling agent 2,4-dinitrophenol (DNP)

1980 • 41 citations

Ultrastructural influence of reperfusing dog myocardium with calcium-free blood after coronary artery occlusion.

1978 • 40 citations

Determinants of hypoxic contracture in isolated heart muscle preparations

1979 • 40 citations

Myocardial stiffness during hypoxic and reoxygenation contracture

1980 • 36 citations

Calcium-induced damage of rat heart mitochondria

1975 • 34 citations

The influence of ATP depletion on the action of phospholipase C on cardiac myocyte membrane phospholipids

1981 • 34 citations

Physical stress-mediated enzyme release from calcium-deficient hearts

1983 • 31 citations

Association of phospholipase A with a myocardial membrane preparation containing the (Na+ + K+)-Mg2+-ATPase

1972 • 31 citations

Calcium overload and mechanical function in posthypoxic myocardium: biphasic effect of pH during hypoxia

1979 • 28 citations

The effect of isolation on myocardial properties

1976 • 28 citations

The effects of isoprenaline and tyramine on the 45calcium uptake, the total calcium content and the contraction force of isolated guinea-pig atria in dependence on different extracellular hydrogen ion concentrations

1972 • 25 citations

Role of sarcolemmal changes in cardiac pathophysiology.

1976 • 22 citations

A theory concerning the course of events in angina and myocardial infarction.

1975 • 18 citations

Resistance of contracting myocardium to swelling with hypoxia and glycolytic blockade

1979 • 15 citations

Influence of contractile state on the size of the extracellular space in isolated ventricular myocardium

1979 • 15 citations

A kinetic study of the pH optimum of canine cardiac cathepsin D

1980 • 14 citations

Increased calcium and water concentrations in the left ventricle of hypertensive rats

1969 • 11 citations

ELECTROPHYSIOLOGICAL AND BIOCHEMICAL DERANGEMENTS IN ISCHEMIC MYOCARDIUM: INTERACTIONS INVOLVING THE CELL MEMBRANE

1981 • 11 citations

Oxygen as an Inductor of Divalent Cation Permeability through Biological and Model Lipid Membranes

1982 • 9 citations

The effects of prostacyclin (PGI2) and prostaglandin E1 on myocardial and coronary arterial cyclic nucleotide levels and cardiac hemodynamics in dogs

1979 • 5 citations

Myocardial Reoxygenation Damage can be Circumvented

1983 • 4 citations

Implications of electrogenic Na/Ca exchange in mammalian heart: Computer model

1983 • 2 citations

Calcium fluxes and myocardial hypoxia

1982 • 2 citations