Non-viral approaches to gene therapy

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

1987 • 4,937 citations

Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein

1993 • 2,330 citations

Genetic immunization is a simple method for eliciting an immune response

1992 • 1,505 citations

Polyamidoamine cascade polymers mediate efficient transfection of cells in culture

1993 • 1,186 citations

Receptor-mediated in vitro gene transformation by a soluble DNA carrier system.

1987 • 841 citations

Systemic Gene Expression After Intravenous DNA Delivery into Adult Mice

1993 • 725 citations

Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA.

1989 • 709 citations

Transferrin-polycation conjugates as carriers for DNA uptake into cells.

1990 • 657 citations

Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle.

1992 • 657 citations

Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells.

1991 • 485 citations

Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes.

1992 • 483 citations

Increased Expression of DNA Cointroduced with Nuclear Protein in Adult Rat Liver

1989 • 459 citations

Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy

1993 • 439 citations

Adenovirus enhancement of transferrin-polylysine-mediated gene delivery.

1991 • 431 citations

Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles.

1991 • 425 citations

Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand

1992 • 325 citations

Immunotherapy of malignancy by in vivo gene transfer into tumors.

1993 • 320 citations

High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles.

1992 • 317 citations

Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA

1990 • 297 citations

The pH-dependent bilayer destabilization by an amphipathic peptide

1987 • 292 citations

Specific gene transfer mediated by lactosylated poly-L-lysine into hepatoma cells

1993 • 288 citations

Aerosol gene delivery in vivo.

1992 • 271 citations

Adenovirus-induced release of epidermal growth factor and pseudomonas toxin into the cytosol of KB cells during receptor-mediated endocytosis

1983 • 256 citations

Recombinant platelet-derived growth factor B gene expression in porcine arteries induce intimal hyperplasia in vivo.

1993 • 247 citations

Synthetic gene-transfer vectors

1993 • 218 citations

Conjugation of poly-L-lysine to albumin and horseradish peroxidase: a novel method of enhancing the cellular uptake of proteins.

1978 • 183 citations

Hepatic gene therapy: adenovirus enhancement of receptor-mediated gene delivery and expression in primary hepatocytes.

1993 • 169 citations

Destabilization of phosphatidylethanolamine liposomes at the hexagonal phase transition temperature

1986 • 159 citations

DNA-binding transferrin conjugates as functional gene-delivery agents: synthesis by linkage of polylysine or ethidium homodimer to the transferrin carbohydrate moiety

1991 • 142 citations

Direct in vivo gene introduction into rat kidney

1992 • 133 citations

Use of N-terminal modified poly(L-lysine)-antibody conjugate as a carrier for targeted gene delivery in mouse lung endothelial cells

1992 • 129 citations

[42] Receptor-mediated transport of DNA into eukaryotic cells

1993 • 115 citations

pH-dependent lysis of liposomes by adenovirus

1986 • 104 citations

Receptor-mediated endocytosis and nuclear transport of a transfecting DNA construct

1992 • 102 citations

Chicken adenovirus (CELO virus) particles augment receptor-mediated DNA delivery to mammalian cells and yield exceptional levels of stable transformants

1993 • 93 citations

Cationic liposomes enhance targeted delivery and expression of exogenous DNA mediated by N-terminal modified poly(l-lysine)-antibody conjugate in mouse lung endothelial cells

1992 • 93 citations

Evidence for targeted gene transfer by receptor-mediated endocytosis

1990 • 92 citations

Antiviral activity of conjugates between poly(l-lysine) and synthetic oligodeoxyribonucleotides

1988 • 91 citations

Synthesis and characterization of a trigalactosylated bisacridine compound to target DNA to hepatocytes

1993 • 75 citations

Condensation of vector DNA by the chromosomal protein HMG1 results in efficient transfection

1988 • 59 citations

Adenovirus-dependent increase in cell membrane permeability.

1985 • 48 citations

Cationic Lipid-Mediated Delivery of Polynucleotides

1993 • 24 citations

Gene transfer into intact vertebrate embryos.

1991 • 11 citations