Selective phospholipase C activation

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal

1962 • 2,192 citations

Handbook of experimental pharmacology

1984 • 1,599 citations

Peptide Growth Factors and Their Receptors

1991 • 1,221 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

Studies of Inositol Phospholipid-Specific Phospholipase C

1989 • 914 citations

Calcium-mobilizing receptors, polyphosphoinositides, and the generation of second messengers.

1986 • 831 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

Increase of the Catalytic Activity of Phospholipase C-γ1 by Tyrosine Phosphorylation

1990 • 650 citations

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

1987 • 609 citations

Sequence similarity of phospholipase C with the non-catalytic region of src

1988 • 541 citations

Calcium oscillations.

1990 • 520 citations

PDGF induction of tyrosine phosphorylation of GTPase activating protein

1989 • 478 citations

T Cell Antigen Receptor-Mediated Activation of Phospholipase C Requires Tyrosine Phosphorylation

1990 • 476 citations

The Actin-Binding Protein Profilin Binds to PIP ₂ and Inhibits Its Hydrolysis by Phospholipase C

1990 • 472 citations

Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase.

1989 • 442 citations

Binding of Transforming Protein, P47 ^gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

1990 • 433 citations

Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium.

1989 • 402 citations

Antiphosphotyrosine Recovery of Phospholipase C Activity After EGF Treatment of A-431 Cells

1988 • 324 citations

Protein-tyrosine phosphatases: The other side of the coin

1989 • 308 citations

Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-gamma in quiescent BALB/c 3T3 cells.

1989 • 262 citations

Monoclonal antibodies to three phospholipase C isozymes from bovine brain.

1988 • 256 citations

Non-catalytic domains of cytoplasmic protein-tyrosine kinases: regulatory elements in signal transduction.

1988 • 250 citations

Platelet-derived growth factor (PDGF) binding promotes physical association of PDGF receptor with phospholipase C.

1989 • 235 citations

A point mutation at the ATP-binding site of the EGF-receptor abolishes signal transduction.

1988 • 215 citations

Feedback regulation of phospholipase C-beta by protein kinase C.

1990 • 212 citations

Platelet-Derived Growth Factor (PDGF)-Dependent Association of Phospholipase C-γ with the PDGF Receptor Signaling Complex

1990 • 204 citations

Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG).

1989 • 203 citations

Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.

1990 • 195 citations

Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor.

1990 • 188 citations

Activated type I phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulation.

1990 • 185 citations

Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro.

1990 • 178 citations

Effect of Phospholipase C-γ Overexpression on PDGF-induced Second Messengers and Mitogenesis

1990 • 170 citations

Phosphoinositide metabolism and the control of cell proliferation

1989 • 165 citations

Purification from bovine liver membranes of a guanine nucleotide-dependent activator of phosphoinositide-specific phospholipase C. Immunologic identification as a novel G-protein alpha subunit.

1990 • 164 citations

A Second Type of Rat Phosphoinositide-specific Phospholipase C Containing a src-related Sequence Not Essential for Phosphoinositide-hydrolyzing Activity

1989 • 160 citations

Stimulation of Phospholipase C-γ1 Membrane Association by Epidermal Growth Factor

1990 • 153 citations

Tyrosine Phosphorylation of Phospholipase C-II in Vitro by the Epidermal Growth Factor Receptor

1989 • 145 citations

Phospholipase C-gamma, a substrate for PDGF receptor kinase, is not phosphorylated on tyrosine during the mitogenic response to CSF-1.

1989 • 145 citations

Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells.

1990 • 136 citations

Brain phospholipase C isozymes: differential mRNA localizations by in situ hybridization.

1989 • 130 citations

Tissue- and cell type-specific expression of mRNAS for four types of inositol phospholipid-specific phospholipase C

1989 • 114 citations

Phosphorylation of Phospholipase C-γ by cAMP-dependent Protein Kinase

1989 • 112 citations

Regulation of phosphoinositide-specific phospholipase C

1990 • 111 citations

Platelet-derived growth factor (PDGF)-dependent association of phospholipase C-gamma with the PDGF receptor signaling complex.

1990 • 86 citations

Phospholipase C-148: Chromosomal Location and Deletion Mapping of Functional Domains

1988 • 81 citations

Selectivity of phospholipase C phosphorylation by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains.

1990 • 69 citations

Effects of substitution of threonine 654 of the epidermal growth factor receptor on epidermal growth factor-mediated activation of phospholipase C.

1990 • 69 citations

Phospholipase C I and II brain isozymes: immunohistochemical localization in neuronal systems in rat brain.

1988 • 66 citations

Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes

1988 • 64 citations

A receptor and G-protein-regulated polyphosphoinositide-specific phospholipase C from turkey erythrocytes. I. Purification and properties.

1990 • 61 citations

Receptors For Epidermal Growth Factor And Other Polypeptide Mitogens

1987 • 58 citations

Phospholipase C Isozymes: Structural and Functional Similarities

2007 • 57 citations

A receptor and G-protein-regulated polyphosphoinositide-specific phospholipase C from turkey erythrocytes. II. P2Y-purinergic receptor and G-protein-mediated regulation of the purified enzyme reconstituted with turkey erythrocyte ghosts.

1990 • 50 citations

Phosphoinositide metabolism and control of cell proliferation

1989 • 17 citations

Growth factor signaling pathways: phosphoinositide metabolism and phosphorylation of phospholipase C.

1989 • 12 citations

Purification and characterization of P47gag-crk expressed in insect cells.

1990 • 11 citations