Resistance to clopidogrel: A review of the evidence

A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)

1996 • 6,350 citations

Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation

2001 • 6,336 citations

Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes

2004 • 4,752 citations

A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee

1996 • 2,812 citations

Pharmacogenomics — Drug Disposition, Drug Targets, and Side Effects

2003 • 1,750 citations

Clopidogrel for Coronary Stenting

2003 • 1,547 citations

Clopidogrel Resistance Is Associated With Increased Risk of Recurrent Atherothrombotic Events in Patients With Acute Myocardial Infarction

2004 • 1,374 citations

Genetic contribution to variable human CYP3A-mediated metabolism

2002 • 953 citations

Variability in platelet responsiveness to clopidogrel among 544 individuals

2005 • 773 citations

Atorvastatin Reduces the Ability of Clopidogrel to Inhibit Platelet Aggregation

2003 • 700 citations

Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement

2003 • 601 citations

Central role of the P2Y12 receptor in platelet activation

2004 • 532 citations

Contribution of Hepatic Cytochrome P450 3A4 Metabolic Activity to the Phenomenon of Clopidogrel Resistance

2004 • 497 citations

Molecular Basis for ADP-induced Platelet Activation

1998 • 463 citations

Structure and Stereochemistry of the Active Metabolite of Clopidogrel

2002 • 452 citations

Resistance to thienopyridines: Clinical detection of coronary stent thrombosis by monitoring of vasodilator‐stimulated phosphoprotein phosphorylation

2003 • 447 citations

Pharmacokinetic-Pharmacodynamic Drug Interactions with HMG-CoA Reductase Inhibitors

2002 • 422 citations

Adenosine Diphosphate–Induced Platelet Aggregation Is Associated With P2Y ₁₂ Gene Sequence Variations in Healthy Subjects

2003 • 415 citations

Aspirin and Clopidogrel

2004 • 407 citations

The Metabolism of Clopidogrel Is Catalyzed by Human Cytochrome P450 3A and Is Inhibited by Atorvastatin

2003 • 374 citations

Meta-analysis of randomized and registry comparisons of ticlopidine with clopidogrel after stenting

2002 • 361 citations

Individual variations of platelet inhibition after loading doses of clopidogrel

2002 • 336 citations

Platelet Function Testing in Cardiovascular Diseases

2004 • 319 citations

High clopidogrel loading dose during coronary stenting: effects on drug response and interindividual variability

2004 • 308 citations

Genetic Variability in CYP3A5 and its Possible Consequences

2004 • 298 citations

Lack of Adverse Clopidogrel–Atorvastatin Clinical Interaction From Secondary Analysis of a Randomized, Placebo-Controlled Clopidogrel Trial

2003 • 270 citations

Clopidogrel loading dose regimens: kinetic profile of pharmacodynamic response in healthy subjects.

1999 • 252 citations

Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin.

2000 • 228 citations

Specific Impairment of Human Platelet P2Y _AC ADP Receptor–Mediated Signaling by the Antiplatelet Drug Clopidogrel

1999 • 216 citations

Platelet function assays

2003 • 213 citations

Subacute stent thrombosis: Evolving issues and current concepts

1996 • 211 citations

Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270

2003 • 210 citations

Clopidogrel inhibits the binding of ADP analogues to the receptor mediating inhibition of platelet adenylate cyclase.

1992 • 202 citations

Lipophilic statins interfere with the inhibitory effects of clopidogrel on platelet function — a flow cytometry study

2003 • 201 citations

Platelet aggregation according to body mass index in patients undergoing coronary stenting: should clopidogrel loading-dose be weight adjusted?

2004 • 192 citations

Molecular bases of defective signal transduction in the platelet P2Y ₁₂ receptor of a patient with congenital bleeding

2003 • 189 citations

Resistance to aspirin in vitro is associated with increased platelet sensitivity to adenosine diphosphate

2002 • 187 citations

In vitro comparative inhibition profiles of major human drug metabolising cytochrome P450 isozymes (CYP2C9, CYP2D6 and CYP3A4) by HMG-CoA reductase inhibitors

1996 • 178 citations

Clopidogrel inhibits platelet-leukocyte interactions and thrombin receptor agonist peptide-induced platelet activation in patients with an acute coronary syndrome

2004 • 171 citations

P2Y ₁₂ H2 Haplotype Is Associated With Peripheral Arterial Disease

2003 • 165 citations

Assessment of platelet function assays

1998 • 163 citations

Absence of Interaction Between Atorvastatin or Other Statins and Clopidogrel

2004 • 161 citations

The difference between clopidogrel responsiveness and posttreatment platelet reactivity

2004 • 158 citations

Platelet purinergic receptors

2003 • 158 citations

Antiplatelet therapy

1996 • 149 citations

Atorvastatin Does Not Affect the Antiplatelet Potency of Clopidogrel When It Is Administered Concomitantly for 5 Weeks in Patients With Acute Coronary Syndromes

2004 • 146 citations

Platelet inhibitor agents in cardiovascular disease: An update

1989 • 143 citations

Durability of platelet inhibition by clopidogrel

2003 • 138 citations

Effects of Statins on Platelet Inhibition by a High Loading Dose of Clopidogrel

2003 • 136 citations

Frequency of nonresponse antiplatelet activity of clopidogrel during pretreatment for cardiac catheterization

2004 • 132 citations

Comparison of clinical benefits of clopidogrel therapy in patients with acute coronary syndromes taking atorvastatin versus other statin therapies

2003 • 124 citations

Single-dose pharmacodynamics of clopidogrel

2000 • 121 citations

Effects of clopidogrel, aspirin and combined therapy in a porcine ex vivo model of high-shear induced stent thrombosis

1998 • 121 citations

Effect of clopidogrel pretreatment on inflammatory marker expression in patients undergoing percutaneous coronary intervention

2004 • 119 citations

Genetics of the Variable Expression of CYP3A in Humans

2004 • 118 citations

Limited early antiplatelet effect of 300 mg clopidogrel in patients with aspirin therapy undergoing percutaneous coronary interventions

2004 • 111 citations

Platelet Anti-Aggregating Activity and Tolerance of Clopidogrel in Atherosclerotic Patients

1996 • 109 citations

Impact of angina class on inhibition of platelet aggregation following clopidogrel loading in patients undergoing coronary intervention: Do we need more aggressive dosing regimens in unstable angina?

2003 • 105 citations

Effect of clopidogrel pretreatment on periprocedural rise in C-reactive protein after percutaneous coronary intervention

2004 • 101 citations

Heparin-induced thrombocytopenia in France, 1980-1998.

1999 • 97 citations

Antiplatelet effects of a 600 mg loading dose of clopidogrel are not attenuated in patients receiving atorvastatin or simvastatin for at least 4 weeks prior to coronary artery stenting

2004 • 96 citations

Scientific and therapeutic insights into the role of the platelet P2Y12 receptor in thrombosis

2003 • 77 citations

Effect of 300- and 450-mg clopidogrel loading doses on membrane and soluble P-selectin in patients undergoing coronary stent implantation

2002 • 61 citations

Prothrombotic and antithrombotic pathways in acute coronary syndromes

2003 • 58 citations

Absence of interaction between atorvastatin or other statins and clopidogrel

2005 • 11 citations