The influence of the P-glycoprotein inhibitor zosuquidar trihydrochloride (LY335979) on the brain penetration of paclitaxel in mice

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

1996 • 1,268 citations

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1997 • 871 citations

Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes.

2000 • 384 citations

Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979.

1996 • 329 citations

MW/Pharm, an integrated software package for drug dosage regimen calculation and therapeutic drug monitoring

1992 • 323 citations

Increased penetration of paclitaxel into the brain by inhibition of P-Glycoprotein.

2003 • 238 citations

Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities.

1999 • 173 citations

A Phase I Trial of a Potent P-Glycoprotein Inhibitor, Zosuquidar Trihydrochloride (LY335979), Administered Intravenously in Combination with Doxorubicin in Patients with Advanced Malignancy

2004 • 148 citations

Reversal of Multidrug Resistance by the P-Glycoprotein Modulator, LY335979, from the Bench to the Clinic

2001 • 147 citations

Modulation of P‐glycoprotein but not MRP1‐ or BCRP‐mediated drug resistance by LY335979

2002 • 138 citations

Taxol metabolism and disposition in cancer patients.

1995 • 134 citations

Pharmacological characterization of LY335979: A potent cyclopropyldibenzosuberane modulator of P-glycoprotein

1997 • 86 citations

Determination of paclitaxel and metabolites in mouse plasma, tissues, urine and faeces by semi-automated reversed-phase high-performance liquid chromatography

1995 • 77 citations

Liquid chromatography/nuclear magnetic resonance spectroscopy and liquid chromatography/mass spectrometry identification of novel metabolites of the multidrug resistance modulator LY335979 in rat bile and human liver microsomal incubations.

1998 • 42 citations

A population pharmacokinetic model for doxorubicin and doxorubicinol in the presence of a novel MDR modulator, zosuquidar trihydrochloride (LY335979)

2003 • 40 citations

RS-33295-198: a novel, potent modulator of P-glycoprotein-mediated multidrug resistance.

1995 • 40 citations

Metabolism and excretion of paclitaxel after oral administration in combination with cyclosporin A and after i.v. administration

2000 • 27 citations

A population pharmacokinetic model for paclitaxel in the presence of a novel P‐gp modulator, Zosuquidar Trihydrochloride (LY335979)

2003 • 26 citations

Bioanalysis of zosuquidar trihydrochloride (LY335979) in small volumes of human and murine plasma by ion−pairing reversed-phase high-performance liquid chromatography

2003 • 3 citations