MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae

TOR Signaling in Growth and Metabolism

2006 • 5,643 citations

Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae

1998 • 5,253 citations

Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes

2000 • 4,803 citations

Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale

1997 • 4,531 citations

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

2003 • 3,673 citations

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

1999 • 2,199 citations

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

1991 • 1,937 citations

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

2001 • 1,892 citations

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

2004 • 1,847 citations

Three new dominant drug resistance cassettes for gene disruption inSaccharomyces cerevisiae

1999 • 1,793 citations

Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

2000 • 1,756 citations

Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

2006 • 1,505 citations

Extrachromosomal rDNA Circles— A Cause of Aging in Yeast

1997 • 1,477 citations

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

2004 • 1,337 citations

Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

2005 • 1,272 citations

Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway

2004 • 1,229 citations

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

2002 • 1,051 citations

Influence of TOR kinase on lifespan in C. elegans

2003 • 1,017 citations

Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1

2002 • 971 citations

Extension of chronological life span in yeast by decreased TOR pathway signaling

2006 • 939 citations

The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells

2004 • 939 citations

The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors

1999 • 918 citations

Regulation of Longevity and Stress Resistance by Sch9 in Yeast

2001 • 858 citations

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

2006 • 856 citations

Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity

1998 • 759 citations

Sir2 links chromatin silencing, metabolism, and aging

2000 • 725 citations

Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

2003 • 706 citations

Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae

1991 • 700 citations

SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast.

1997 • 673 citations

Toward a unified theory of caloric restriction and longevity regulation

2005 • 568 citations

Sir2-Independent Life Span Extension by Calorie Restriction in Yeast

2004 • 434 citations

A Role for SIR-2.1 Regulation of ER Stress Response Genes in Determining C. elegans Life Span

2005 • 399 citations

Sir2 Blocks Extreme Life-Span Extension

2005 • 380 citations

An intervention resembling caloric restriction prolongs life span and retards aging in yeast

2000 • 377 citations

Yeast PKA represses Msn2p/Msn4p-dependent gene expression to regulate growth, stress response and glycogen accumulation

1998 • 356 citations

Retarded Growth, Life Span, Ultimate Body Size and Age Changes in the Albino Rat after Feeding Diets Restricted in Calories

1939 • 347 citations

eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans

2007 • 342 citations

SOD2 Functions Downstream of Sch9 to Extend Longevity in Yeast

2003 • 327 citations

Extension of Human Cell Lifespan by Nicotinamide Phosphoribosyltransferase

2007 • 309 citations

Acute glucose starvation activates the nuclear localization signal of a stress-specific yeast transcription factor

2002 • 296 citations

Manipulation of a Nuclear NAD+ Salvage Pathway Delays Aging without Altering Steady-state NAD+ Levels

2002 • 289 citations

Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA

1997 • 280 citations

Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO

2005 • 260 citations

Association of the RENT complex with nontranscribed and coding regions of rDNA and a regional requirement for the replication fork block protein Fob1 in rDNA silencing

2003 • 233 citations

Mechanism of Nicotinamide Inhibition and Transglycosidation by Sir2 Histone/Protein Deacetylases

2003 • 230 citations

HST2 Mediates SIR2 -Independent Life-Span Extension by Calorie Restriction

2005 • 228 citations

Longevity Regulation inSaccharomyces cerevisiae: Linking Metabolism, Genome Stability, and Heterochromatin

2003 • 227 citations

A search in the genome ofSaccharomyces cerevisiae for genes regulated via stress response elements

1998 • 204 citations

Nicotinamide Clearance by Pnc1 Directly Regulates Sir2-Mediated Silencing and Longevity

2004 • 188 citations

Chronological aging‐independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae

2003 • 185 citations

Sip2p and its partner Snf1p kinase affect aging in S. cerevisiae

2000 • 165 citations

Decreased Lifespan in the Absence of Expression of the Mitochondrial Small Heat Shock Protein Hsp22 in Drosophila

2004 • 145 citations

Chemical Activation of Sir2-Dependent Silencing by Relief of Nicotinamide Inhibition

2005 • 142 citations

Oscillatory nucleocytoplasmic shuttling of the general stress response transcriptional activators Msn2 and Msn4 in Saccharomyces cerevisiae

2003 • 141 citations

Some Aspects of Cell Division in Saccharomyces cerevisiae

1950 • 137 citations

Identification and functional analysis of the Saccharomyces cerevisiae nicotinamidase gene, PNC1

2001 • 124 citations

Molecular mechanisms of yeast aging

1998 • 117 citations

The Ras and Sch9 pathways regulate stress resistance and longevity

2003 • 114 citations

Sec13 Shuttles between the Nucleus and the Cytoplasm and Stably Interacts with Nup96 at the Nuclear Pore Complex

2003 • 87 citations

Snf1 Protein Kinase Regulates Adr1 Binding to Chromatin but Not Transcription Activation

2002 • 86 citations

Nitrogen Availability and TOR Regulate the Snf1 Protein Kinase in Saccharomyces cerevisiae

2006 • 83 citations

THE JOURNAL OF NUTRITION: RETARDED GROWTH, LIFE SPAN, ULTIMATE BODY SIZE AND AGE CHANGES IN THE ALBINO RAT AFTER FEEDING DIETS RESTRICTED IN CALORIES

2009 • 76 citations

Life long calorie restriction increases heat shock proteins and proteasome activity in soleus muscles of Fisher 344 rats

2004 • 69 citations

Nutrient starvation promotes condensin loading to maintain rDNA stability

2007 • 68 citations

Protein Kinase A Regulates Constitutive Expression of Small Heat-Shock Genes in an Msn2/4p-Independent and Hsf1p-Dependent Manner in Saccharomyces cerevisiae

2004 • 63 citations

Rap1p Requires Gcr1p and Gcr2p Homodimers to Activate Ribosomal Protein and Glycolytic Genes, Respectively

2001 • 60 citations

The Dihydrolipoamide Acetyltransferase Is a Novel Metabolic Longevity Factor and Is Required for Calorie Restriction-mediated Life Span Extension

2007 • 54 citations

Response to Comment on " HST2 Mediates SIR2 -Independent Life-Span Extension by Calorie Restriction"

2006 • 17 citations

Commentary

2000 • 16 citations

Trehalose, glycogen and ethanol metabolism in thegcrl mutant ofSaccharomyces cerevisiae

2003 • 6 citations