Airway smooth muscle tone modulates mechanically induced cytoskeletal stiffening and remodeling

Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates

2001 • 2,089 citations

Extracellular Matrix Rigidity Causes Strengthening of Integrin–Cytoskeleton Linkages

1997 • 1,218 citations

National Asthma Education and Prevention Program

2002 • 975 citations

The relationship between force and focal complex development

2002 • 876 citations

Adhesion-Dependent Cell Mechanosensitivity

2003 • 847 citations

Airway Structural Alterations Selectively Associated with Severe Asthma

2003 • 784 citations

Microrheology of Human Lung Epithelial Cells Measured by Atomic Force Microscopy

2003 • 699 citations

Cell prestress. I. Stiffness and prestress are closely associated in adherent contractile cells

2002 • 664 citations

Airway Smooth Muscle, Tidal Stretches, and Dynamically Determined Contractile States

1997 • 451 citations

Hyperplasia of Smooth Muscle in Mild to Moderate Asthma without Changes in Cell Size or Gene Expression

2004 • 383 citations

Invited Review: Focal adhesion and small heat shock proteins in the regulation of actin remodeling and contractility in smooth muscle

2001 • 288 citations

Intracellular stress tomography reveals stress focusing and structural anisotropy in cytoskeleton of living cells

2003 • 257 citations

Changes in biophysical and biochemical properties of single bronchial smooth muscle cells from asthmatic subjects

2002 • 251 citations

Actin polymerization stimulated by contractile activation regulates force development in canine tracheal smooth muscle

1999 • 250 citations

Potent bronchoprotective effect of deep inspiration and its absence in asthma

2000 • 238 citations

Why are long-acting beta-adrenoceptor agonists long-acting?

1994 • 234 citations

Direct Effects of Interleukin-13 on Signaling Pathways for Physiological Responses in Cultured Human Airway Smooth Muscle Cells

2001 • 216 citations

A finite element model of cell deformation during magnetic bead twisting

2002 • 207 citations

Selected Contribution: Time course and heterogeneity of contractile responses in cultured human airway smooth muscle cells

2001 • 180 citations

Stiffness changes in cultured airway smooth muscle cells

2002 • 173 citations

Pharmacological Management to Reduce Exacerbations in Adults With Asthma

2004 • 171 citations

Mechanical properties of cultured human airway smooth muscle cells from 0.05 to 0.4 Hz

2000 • 167 citations

Preface

2002 • 154 citations

Deep Inspiration-induced Bronchoprotection Is Stronger than Bronchodilation

2000 • 144 citations

Rheology of airway smooth muscle cells is associated with cytoskeletal contractile stress

2004 • 142 citations

Pharmacological activation changes stiffness of cultured human airway smooth muscle cells

1996 • 130 citations

Actin reorganization in airway smooth muscle cells involves G_qand G_i-2activation of Rho

1999 • 116 citations

Localized mechanical stress induces time-dependent actin cytoskeletal remodeling and stiffening in cultured airway smooth muscle cells

2004 • 112 citations

Membrane and acto-myosin tension promote clustering of adhesion proteins

2004 • 110 citations

Mechanical strain increases cell stiffness through cytoskeletal filament reorganization

2003 • 103 citations

Cytoskeletal mechanics in adherent human airway smooth muscle cells: probe specificity and scaling of protein-protein dynamics

2004 • 99 citations

Strain Reorganizes Focal Adhesions and Cytoskeleton in Cultured Airway Smooth Muscle Cells

1997 • 97 citations

Implications of heterogeneous bead behavior on cell mechanical properties measured with magnetic twisting cytometry

1999 • 97 citations

Strain increases airway smooth muscle cell proliferation.

1994 • 92 citations

Strain increases airway smooth muscle contractile and cytoskeletal proteins in vitro

1997 • 86 citations

Force-induced focal adhesion translocation: effects of force amplitude and frequency

2004 • 80 citations

Actin depolymerization via the β-adrenoceptor in airway smooth muscle cells: a novel PKA-independent pathway

2001 • 66 citations

Smooth Muscle Actin Determines Mechanical Force-induced p38 Activation

2005 • 51 citations

Selected Contribution: Mechanical strain increases force production and calcium sensitivity in cultured airway smooth muscle cells

2000 • 50 citations

Mechanical strain increases contractile enzyme activity in cultured airway smooth muscle cells

1995 • 45 citations

Mechanical strain increases velocity and extent of shortening in cultured airway smooth muscle cells

1999 • 31 citations

Effects of tidal volume stretch on airway constriction in vivo

2001 • 22 citations

Relaxation kinetics of formoterol and salmeterol in the guinea pig trachea in vitro

2004 • 19 citations

Effects of cAMP on serotonin evoked calcium transients in cultured rat airway smooth muscle cells

1997 • 7 citations