Mutations of the epidermal growth factor receptor gene in atypical adenomatous hyperplasia and bronchioloalveolar carcinoma of the lung

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

2004 • 11,185 citations

EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

2004 • 9,201 citations

EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib

2004 • 4,293 citations

Multi-Institutional Randomized Phase II Trial of Gefitinib for Previously Treated Patients With Advanced Non–Small-Cell Lung Cancer

2003 • 2,874 citations

Efficacy of Gefitinib, an Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase, in Symptomatic Patients With Non–Small Cell Lung Cancer

2003 • 2,522 citations

Clinical and Biological Features Associated With Epidermal Growth Factor Receptor Gene Mutations in Lung Cancers

2005 • 2,285 citations

Gefitinib-Sensitizing EGFR Mutations in Lung Cancer Activate Anti-Apoptotic Pathways

2004 • 1,600 citations

Multiple primary lung cancers

1975 • 1,243 citations

Mutations of the Epidermal Growth Factor Receptor Gene in Lung Cancer

2004 • 1,206 citations

Mass screening for lung cancer with mobile spiral computed tomography scanner

1998 • 921 citations

Peripheral lung cancer: screening and detection with low-dose spiral CT versus radiography.

1996 • 847 citations

EGFR Mutations in Non–Small-Cell Lung Cancer: Analysis of a Large Series of Cases and Development of a Rapid and Sensitive Method for Diagnostic Screening With Potential Implications on Pharmacologic Treatment

2005 • 792 citations

Intragenic ERBB2 kinase mutations in tumours

2004 • 753 citations

Bronchioloalveolar Pathologic Subtype and Smoking History Predict Sensitivity to Gefitinib in Advanced Non–Small-Cell Lung Cancer

2004 • 749 citations

Somatic Mutations of the HER2 Kinase Domain in Lung Adenocarcinomas

2005 • 652 citations

Lung cancer

2000 • 578 citations

High Frequency of Epidermal Growth Factor Receptor Mutations with Complex Patterns in Non–Small Cell Lung Cancers Related to Gefitinib Responsiveness in Taiwan

2004 • 544 citations

Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung

2001 • 443 citations

K-ras oncogene activation in atypical alveolar hyperplasias of the human lung.

1996 • 216 citations

Atypical Adenomatous Hyperplasia of the Lung: Implications for the Pathogenesis of Peripheral Lung Adenocarcinoma

1999 • 190 citations

Lung Adenocarcinoma With Mixed Bronchioloalveolar and Invasive Components

2003 • 180 citations

K-ras mutations are a relatively late event in the pathogenesis of lung carcinomas

1995 • 170 citations

p53 and K-ras mutations in lung cancers from former and never-smoking women.

2001 • 125 citations

Bronchioloalveolar Carcinoma of the Lung 3 Centimeters or Less in Diameter: A Prognostic Assessment

2004 • 119 citations

Prognostic value of bronchiolo-alveolar carcinoma component of small lung adenocarcinoma

1999 • 113 citations

BRONCHIOLOALVEOLAR LUNG CARCINOMAS: K-ras MUTATIONS ARE CONSTANT EVENTS IN THE MUCINOUS SUBTYPE

1996 • 110 citations

Promoter hypermethylation of the O6-methylguanine-DNA methyltransferase gene: more common in lung adenocarcinomas from never-smokers than smokers and associated with tumor progression.

2003 • 109 citations

THE PATTERN OF K-rasMUTATION IN PULMONARY ADENOCARCINOMA DEFINES A NEW PATHWAY OF TUMOUR DEVELOPMENT IN THE HUMAN LUNG

1997 • 94 citations

Monoclonality of Atypical Adenomatous Hyperplasia of the Lung

1999 • 90 citations

Association of point mutation in c-Ki-ras oncogene in lung adenocarcinoma with particular reference to cytologic subtypes

1990 • 86 citations

Detection of c-Ki-ras gene mutation in paraffin sections of adenocarcinoma and atypical bronchioloalveolar cell hyperplasia of human lung

1994 • 77 citations

A Comparison of Trends in the Incidence Rate of Lung Cancer by Histological Type in the Osaka Cancer Registry, Japan and in the Surveillance, Epidemiology and End Results Program, USA

2003 • 74 citations

K-ras Gene Mutation Enhances Motility of Immortalized Airway Cells and Lung Adenocarcinoma Cells via Akt Activation

2004 • 71 citations

High K-ras mutation rates in goblet-cell-type adenocarcinomas of the lungs

1995 • 35 citations