K-ras Gene Mutation Enhances Motility of Immortalized Airway Cells and Lung Adenocarcinoma Cells via Akt Activation

Cellular survival: a play in three Akts

1999 • 4,229 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

2001 • 1,824 citations

Increasing complexity of Ras signaling

1998 • 1,069 citations

Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.

2001 • 883 citations

The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.

2003 • 605 citations

The pathway to signal achievement

1993 • 563 citations

Mutational Activation of the K-rasOncogene

1987 • 542 citations

Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation.

2002 • 396 citations

Regulation of Raf-Akt Cross-talk

2002 • 386 citations

AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis

2002 • 341 citations

Akt-Mediated Phosphorylation of the G Protein-Coupled Receptor EDG-1 Is Required for Endothelial Cell Chemotaxis

2001 • 284 citations

Phosphatidylinositol-3 kinase dependent pathways: the role in control of cell growth, survival, and malignant transformation.

2000 • 271 citations

Mutations in N-ras predominate in acute myeloid leukemia

1987 • 239 citations

Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma

2002 • 232 citations

SV40-lnduced Immortalization of Human Cells

1994 • 199 citations

Mutation analysis of the PTEN/MMAC1 gene in lung cancer

1998 • 198 citations

Atypical Adenomatous Hyperplasia of the Lung: Implications for the Pathogenesis of Peripheral Lung Adenocarcinoma

1999 • 190 citations

Genetic model of multi-step breast carcinogenesis involving the epithelium and stroma: clues to tumour-microenvironment interactions

2001 • 189 citations

Functional roles of Akt signaling in mouse skin tumorigenesis

2002 • 185 citations

Akt mediates Rac/Cdc42-regulated cell motility in growth factor-stimulated cells and in invasive PTEN knockout cells

2001 • 171 citations

K-ras mutations are a relatively late event in the pathogenesis of lung carcinomas

1995 • 170 citations

Correlation of Intrinsic Chemoresistance of Non-Small-Cell Lung Cancer Cell Lines With HER-2/neu Gene Expression but Not With ras Gene Mutations

1993 • 170 citations

Akt1 induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells.

2001 • 154 citations

Substrate Specificity of αvβ3Integrin-mediated Cell Migration and Phosphatidylinositol 3-Kinase/AKT Pathway Activation

2000 • 147 citations

Hepatocyte Growth Factor Inhibits Anoikis in Head and Neck Squamous Cell Carcinoma Cells by Activation of ERK and Akt Signaling Independent of NFκB

2002 • 136 citations

Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration

2000 • 116 citations

Ki-ras and p53 mutations are early and late events, respectively, in urethane-induced pulmonary carcinogenesis in A/J mice

1996 • 103 citations

THE PATTERN OF K-rasMUTATION IN PULMONARY ADENOCARCINOMA DEFINES A NEW PATHWAY OF TUMOUR DEVELOPMENT IN THE HUMAN LUNG

1997 • 94 citations

Ras induces NBT-II epithelial cell scattering through the coordinate activities of Rac and MAPK pathways

2002 • 88 citations

RasC is required for optimal activation of adenylyl cyclase and Akt/PKB during aggregation

2001 • 84 citations

Establishment of human peripheral lung epithelial cell lines (HPL1) retaining differentiated characteristics and responsiveness to epidermal growth factor, hepatocyte growth factor, and transforming growth factor beta1.

1997 • 79 citations

Detection of c-Ki-ras gene mutation in paraffin sections of adenocarcinoma and atypical bronchioloalveolar cell hyperplasia of human lung

1994 • 77 citations

Role of PTEN, a Lipid Phosphatase Upstream Effector of Protein Kinase B, in Epithelial Thyroid Carcinogenesis

2002 • 47 citations

Motogenic effect of recombinant HGF on airway epithelial cells during the in vitro wound repair of the respiratory epithelium

2000 • 43 citations

The activation of K-ras gene at an early stage of lung tumorigenesis in mice

1996 • 27 citations

Akt and PTEN: New diagnostic markers of non‐small cell lung cancer?

2001 • 19 citations