Uptake by macrophages of a biotinylated oligo-.alpha.-deoxythymidylate by using mannosylated streptavidin

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

1978 • 2,146 citations

ACIDIFICATION OF THE ENDOCYTIC AND EXOCYTIC PATHWAYS

1986 • 1,977 citations

Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis

1981 • 1,881 citations

Antisense oligonucleotides: a new therapeutic principle

1990 • 1,616 citations

Synthesis of deoxyoligonucleotides on a polymer support

1981 • 870 citations

Specific regulation of gene expression by antisense, sense and antigene nucleic acids

1990 • 769 citations

Characterization of oligonucleotide transport into living cells.

1989 • 739 citations

Receptor-mediated endocytosis

1985 • 577 citations

Weak bases and ionophores rapidly and reversibly raise the pH of endocytic vesicles in cultured mouse fibroblasts.

1982 • 569 citations

The properties of streptavidin, a biotin-binding protein produced by Streptomycetes

1964 • 504 citations

Inhibition of replication and expression of human T-cell lymphotropic virus type III in cultured cells by exogenous synthetic oligonucleotides complementary to viral RNA.

1986 • 403 citations

Conjugates of oligonucleotides and modified oligonucleotides: a review of their synthesis and properties

1990 • 400 citations

Colorimetric determination of neutral sugars by a resorcinol sulfuric acid micromethod

1988 • 343 citations

Specific antiviral activity of a poly(L-lysine)-conjugated oligodeoxyribonucleotide sequence complementary to vesicular stomatitis virus N protein mRNA initiation site.

1987 • 329 citations

Highly efficient chemical synthesis of 2′-O-methyloligoribonucleotides and tetrabiotinylated derivatives; novel probes that are resistant to degradation by RNA or DNA specific nucleases

1989 • 268 citations

Cleavage of disulfide bonds in endocytosed macromolecules. A processing not associated with lysosomes or endosomes.

1990 • 225 citations

Uptake of neoglycoproteins via membrane lectin(s) of L1210 cells evidenced by quantitative flow cytofluorometry and drug targeting

1984 • 222 citations

Biological activity of oligonucleotide-poly(L-lysine) conjugates: mechanism of cell uptake

1990 • 160 citations

Synthesis of alkylating oligonucleotide derivatives containing cholesterol or phenazinium residues at their 3′‐terminus and their interaction with DNA within mammalian cells

1989 • 147 citations

Synthesis, hybridization properties and antiviral activity of lipid-oligodeoxynucleotide conjugates

1990 • 140 citations

Acidification of endocytic compartments and the intracellular pathways of ligands and receptors

1984 • 136 citations

Avidin-biotin technology ten years on: has it lived up to its expectations?

1989 • 122 citations

Sugar‐specific endocytosis of glycoproteins by Lewis lung carcinoma cells

1983 • 118 citations

A simple and efficient procedure for the synthesis of 5′-aminoalkyl oligodeoxynucleotides

1986 • 104 citations

Characterization and biological implications of membrane lectins in tumor, lymphoid and myeloid cells

1988 • 92 citations

Postsecretory modifications of streptavidin

1989 • 88 citations

Cell surface sulfhydryls are required for the cytotoxicity of diphtheria toxin but not of ricin in Chinese hamster ovary cells.

1991 • 86 citations

Enhanced cellular uptake of biotinylated antisense oligonucleotide or peptide mediated by avidin, a cationic protein

1991 • 85 citations

Quantitation of the binding, uptake, and degradation of fluoresceinylated neoglycoproteins by flow cytometry

1987 • 78 citations

Muramyl dipeptide bound to poly-l-lysine substituted with mannose and gluconoyl residues as macrophage activators

1989 • 72 citations

Generation of Macrophage Variants With 5-Azacytidine: Selection for Mannose Receptor Expression

1987 • 62 citations

Tumoricidal activation of murine alveolar macrophages by muramyldipeptide substituted mannosylated serum albumin

1984 • 53 citations

Macrophage activation by MDP bound to neoglycoproteins: metastasis eradication in mice.

1985 • 44 citations

Drug targeting: Anti-HSV-1 activity of mannosylated polymer-bound 9-(2-phosphonylmethoxyethyl)adenine

1990 • 37 citations

Solid phase synthesis of 5',3'-bifunctional oligodeoxyribonucleotides bearing a masked thiol group at the 3'-end

1991 • 31 citations

Estimation of the degradation of endocytosed material by flow cytofluorometry using two neoglycoproteins containing different numbers of fluorescein molecules

1986 • 24 citations

Biotinylated antisense methylphosphonate oligodeoxynucleotides. Inhibition of spliceosome assembly and affinity selection of U1 and U2 small nuclear RNPs.

1991 • 19 citations

Benzoxazinone kanamycin A conjugate. A new fluorescent probe suitable to detect mycoplasmas in cell culture

1990 • 13 citations