Responsiveness to Thyroid Hormone is Enhanced in Rat Hepatocytes Cultured as Spheroids Compared with that in Monolayers: Altered Responsiveness to Thyroid Hormone Possibly Involves Complex Formed on Thyroid Hormone Response Elements

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

1992 • 1,514 citations

RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements

1991 • 1,241 citations

Identification of a retinoic acid responsive element in the retinoic acid receptor & beta;gene

1990 • 1,018 citations

Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors

1992 • 966 citations

Primary culture of parenchymal liver cells on collagen membranes

1975 • 808 citations

Three different fibronectin mRNAs arise by alternative splicing within the coding region

1983 • 713 citations

Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes.

1988 • 534 citations

Spheroidal aggregate culture of rat liver cells: histotypic reorganization, biomatrix deposition, and maintenance of functional activities.

1985 • 508 citations

Modular structure of a chicken lysozyme silencer: Involvement of an unusual thyroid hormone receptor binding site

1990 • 487 citations

Formation of multicellular spheroids composed of adult rat hepatocytes in dishes with positively charged surfaces and under other nonadherent environments

1990 • 437 citations

Hepatocyte proliferation in vitro: its dependence on the use of serum-free hormonally defined medium and substrata of extracellular matrix.

1984 • 376 citations

Reciprocal modulation of growth and differentiated functions of mature rat hepatocytes in primary culture by cell--cell contact and cell membranes.

1983 • 259 citations

Continued high albumin production by multicellular spheroids of adult rat hepatocytes formed in the presence of liver-derived proteoglycans

1989 • 248 citations

Long-term culture of adult rat hepatocyte spheroids

1992 • 201 citations

Triiodothyronine (T3) decreases binding to DNA by T3-receptor homodimers but not receptor-auxiliary protein heterodimers.

1992 • 190 citations

Activation of the tyrosine aminotransferase gene is dependent on synergy between liver-specific and hormone-responsive elements.

1993 • 187 citations

Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers

1994 • 174 citations

Rapid effects of triiodothyronine on hepatic gene expression. Hybridization analysis of tissue-specific triiodothyronine regulation of mRNAS14.

1984 • 161 citations

3,5,3′-Triiodothyronine (T₃) Receptor-Auxiliary Protein (TRAP) Binds DNA and Forms Heterodimers with the T₃Receptor

1991 • 130 citations

Regulation by thyroid hormone of nuclear and mitochondrial genes encoding subunits of cytochrome-c oxidase in rat liver and skeletal muscle.

1992 • 129 citations

Identification of multiple thyroid hormone response elements located far upstream from the rat S14 promoter.

1990 • 113 citations

Antioxidants inhibit tumor necrosis factor-alpha mediated stimulation of interleukin-8, monocyte chemoattractant protein-1, and collagenase expression in cultured human synovial cells.

1996 • 109 citations

Binding characteristics of the thyroid hormone receptor homo- and heterodimers to consensus AGGTCA repeat motifs.

1992 • 94 citations

Tissue-specific regulation of two functional malic enzyme mRNAs by triiodothyronine

1985 • 86 citations

Transcriptional activation and stabilization of malic enzyme mRNA precursor by thyroid hormone.

1988 • 84 citations

Phosphorylation stimulates the transcriptional activity of the human beta 1 thyroid hormone nuclear receptor.

1992 • 76 citations

3,5,3′-Triiodothyronine Receptor Auxiliary Protein (TRAP) Enhances Receptor Binding by Interactions within the Thyroid Hormone Response Element

1991 • 73 citations

Mechanisms for synergistic activation of thyroid hormone receptor and retinoid X receptor on different response elements.

1994 • 66 citations

Coding nucleotide sequence of rat liver malic enzyme mRNA.

1986 • 63 citations

Effects of thyroid and glucocorticoid hormones on the level of messenger ribonucleic acid for iodothyronine type I 5'-deiodinase in rat primary hepatocyte cultures grown as spheroids.

1993 • 50 citations

Cloning of a Complementary Deoxyribonucleic Acid Coding for Human Thyroxine-Binding Globulin (TBG): Existence of Two TBG Messenger Ribonucleic Acid Species Possessing Different 3′-Untranslated Regions

1988 • 45 citations

Retinoid-X receptor (RXR) differentially augments thyroid hormone response in cell lines as a function of the response element and endogenous RXR content.

1995 • 43 citations

Expression of a thyroid hormone-responsive recombinant gene introduced into adult mice livers by replication-defective adenovirus can be regulated by endogenous thyroid hormone receptor.

1994 • 35 citations

A moderate form of hemophilia B is caused by a novel mutation in the protease domain of factor IXVancouver

1989 • 34 citations

A chimeric thyroid hormone receptor constitutively bound to DNA requires retinoid X receptor for hormone-dependent transcriptional activation in yeast.

1994 • 34 citations

Thyroid hormone receptors in a human hepatoma cell line: Multiple receptor forms on isoelectric focusing

1987 • 28 citations

Specific Induction of Fibronectin Gene in Rat Liver by Thyroid Hormone

1990 • 28 citations

A new cis-acting element involved in tissue-selective glucocorticoid inducibility of tyrosine aminotransferase gene expression.

1993 • 21 citations

Loss of thyroid hormone receptor activity in primary cultured rat hepatocytes is reversed by 2-mercaptoethanol

1992 • 10 citations

Modification of thyroid hormone and 9-cis retinoic acid signaling by overexpression of their cognate receptors using adenoviral vector

1997 • 8 citations

The effect of thyroid hormone on fibronectin messenger ribonucleic acid levels in primary cultured rat hepatocytes.

1992 • 8 citations

A complete rat serum albumin cDNA clone directly identified by immunological screening of cDNA expression library.

1987 • 5 citations

Liver-specific Induction of Ribosomal Protein Gene Expression by Amino Acid Starvation in Rats

1993 • 5 citations