Differences in pharmacological profiles of a new generation of benzodiazepine and non-benzodiazepine hypnotics

A simplified method of evaluating dose-effect experiments.

1948 • 7,047 citations

A Note on a Simple Apparatus for Detecting Neurological Deficit in Rats and Mice**College of Pharmacy, University of Nebraska, Lincoln 8.

1957 • 1,671 citations

Type I and Type II GABA _A -Benzodiazepine Receptors Produced in Transfected Cells

1989 • 716 citations

Comparative assays of antiepileptic drugs in mice and rats.

1952 • 638 citations

γ‐Aminobutyric Acid_A Receptor α₅‐Subunit Creates Novel Type II Benzodiazepine Receptor Pharmacology

1990 • 498 citations

Some properties of brain specific benzodiazepine receptors: New evidence for multiple receptors

1979 • 412 citations

Characterization of peripheral-type benzodiazepine binding sites in brain using [3H]Ro 5-4864.

1982 • 384 citations

A synthetic non-benzodiazepine ligand for benzodiazepine receptors: A probe for investigating neuronal substrates of anxiety

1979 • 284 citations

Zolpidem, a novel nonbenzodiazepine hypnotic. I. Neuropharmacological and behavioral effects.

1986 • 274 citations

Specific high-affinity saturable binding of [3H] Ro5-4864 To benzodiazepine binding sites in the rat cerebral cortex

1981 • 240 citations

Pharmacological profile of the imidazopyridine zolpidem at benzodiazepine receptors and electrocorticogram in rats

1985 • 168 citations

Imidazopyridines as a tool for the characterization of benzodiazepine receptors: A proposal for a pharmacological classification as omega receptor subtypes

1988 • 146 citations

A simple and specific screen for benzodiazepine-like drugs

1971 • 145 citations

Evidence for an involvement of GABA in the mediation of the cerebellar cGMP decrease and the anticonvulsant action of diazepam

1975 • 144 citations

Autoradiographic Localization of [³H]Zolpidem Binding Sites in the Rat CNS: Comparison with the Distribution of [³H]Flunitrazepam Binding Sites

1987 • 121 citations

COMPARATIVE ANTICONVULSIVE ACTION OF 3,5,5-TRIMETHYLOXAZOLIDINE-2,4-DIONE (TRIDIONE), DILANTIN AND PHENOBARBITAL

1944 • 120 citations

Effets des anxiolytiques sur la prise de nourriture de rats et de souris plac�s en situation nouvelle ou famili�re

1975 • 118 citations

and inhibition by zopiclone of benzodiazepine binding to rodent brain receptors

1979 • 117 citations

High affinity [3H]zolpidem binding in the rat brain: an imidazopyridine with agonist properties at central benzodiazepine receptors

1986 • 110 citations

Affinity of various ligands for benzodiazepine receptors in rat cerebellum and hippocampus

1984 • 92 citations

In vivo interaction of zolpidem with central benzodiazepine (BZD) binding sites (as labeled by [3H]Ro 15-1788) in the mouse brain. Preferential affinity of zolpidem for the omega 1 (BZD1) subtype.

1988 • 91 citations

LIMITATIONS OF THE BENZODIAZEPINE RECEPTOR NOMENCLATURE: A PROPOSAL FOR A PHARMACOLOGICAL CLASSIFICATION AS OMEGA RECEPTOR SUBTYPES

1988 • 77 citations

Several new benzodiazepines selectively interact with a benzodiazepine receptor subtype

1983 • 66 citations

Anticonvulsant efficacy of clonazepam and the β-carboline ZK 93423 during chronic treatment in amygdala-kindled rats

1987 • 64 citations

Benzodiazepine receptors: Multiple receptors or multiple conformations?

1985 • 48 citations

Effect of diazepam on food consumption in rats

1978 • 43 citations

Enhancement of GABAergic transmission by zolpidem, an imidazopyridine with preferential affinity for type I benzodiazepine receptors

1989 • 42 citations

Further behavioural evidence for the selective sedative action of zolpidem

1988 • 41 citations

Clonazepam selectively increases saccharin ingestion in a two-choice test

1988 • 35 citations

Preferential affinity of 3H-2-oxo-quazepam for type I benzodiazepine recognition sites in the human brain

1988 • 32 citations

Selective affinity of the benzodiazepines quazepam and 2-oxo-quazepam for BZ1 binding site and demonstration of 3H-2-oxo-quazepam as a BZ1 selective radioligand

1988 • 27 citations

Hypnotic action of benzodiazepines: A possible mechanism

1984 • 25 citations

Pharmacological and neurochemical properties of 1,4-diazepines with two annelated heterocycles (‘hetrazepines’)

1985 • 23 citations

Pyrazoloquinolines and zolpidem: Effects on hypertonic saline consumption in rehydrating rats

1988 • 21 citations

Pharmacological studies with quazepam, a new benzodiazepine hypnotic.

1982 • 20 citations

Reduction of reticulata neuronal activity by zolpidem and alpidem, two imidazopyridines with high affinity for type I benzodiazepine receptors

1990 • 20 citations

Relative efficacies of 1,4-diazepines on GABA-stimulated chloride influx in rat brain vesicles

1989 • 7 citations