Mitochondrial DNA damage and altered membrane potential (ΔΨ) in pancreatic acinar cells induced by reactive oxygen species

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Oxidative damage and mitochondrial decay in aging.

1994 • 2,024 citations

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

1997 • 1,762 citations

Somatic mutations of the mitochondrial genome in human colorectal tumours

1998 • 828 citations

Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells.

1988 • 407 citations

Early NF-κB activation is associated with hormone-induced pancreatitis

1998 • 353 citations

Stimulation of “Stress-regulated” Mitogen-activated Protein Kinases (Stress-activated Protein Kinases/c-Jun N-terminal Kinases and p38-Mitogen-activated Protein Kinases) in Perfused Rat Hearts by Oxidative and Other Stresses

1998 • 320 citations

The Source and Role of Oxygen-derived Free Radicals in Three Different Experimental Models

1985 • 200 citations

Oxidative stress: an important phenomenon with pathogenetic significance in the progression of acute pancreatitis

1998 • 158 citations

Oxidative stress in acute and chronic pancreatitis

1995 • 134 citations

Superoxide dismutase and catalase: A possible role in established pancreatitis

1986 • 103 citations

Progressive disruption of acinar cell calcium signaling is an early feature of cerulein-induced pancreatitis in mice

1996 • 90 citations

Defects at Center P Underlie Diabetes-Associated Mitochondrial Dysfunction

1997 • 84 citations

Mitochondrial cytochrome c oxidase subunit IV is phosphorylated by an endogenous kinase

1997 • 84 citations

Mitochondrial membrane potential (delta psi(mt)) in the coordination of p53-independent proliferation and apoptosis pathways in human colonic carcinoma cells.

1998 • 81 citations

Free radical inhibition and serial chemiluminescence in evolving experimental pancreatitis

1990 • 66 citations

Characterization of Promoter Elements Required for Cell-Specific Expression of the Neurotensin/Neuromedin N Gene in a Human Endocrine Cell Line

1995 • 60 citations

Xenobiotic Metabolism, Oxidant Stress and Chronic Pancreatitis

1998 • 46 citations

Increased Cytosolic Ca<sup>2+</sup> Amplifies Oxygen Radical-Induced Alterations of the Ultrastructure and the Energy Metabolism of Isolated Rat Pancreatic Acinar Cells

1998 • 42 citations

Signal transduction mechanisms in neurotensin-mediated cellular regulation

1998 • 42 citations

Effect of Supramaximal Cerulein Stimulation on Mitochondrial Energy Metabolism in Rat Pancreas

1998 • 25 citations

Xanthine Oxidase-Mediated in Response to Cerulein in Intracellular Oxidative Stress Rat Pancreatic Acinar Cells

1993 • 18 citations

Recording of mitochondrial transmembrane potential and volume in cultured rat osteoclasts by confocal laser scanning microscopy.

1997 • 12 citations