In vitro autoradiography of ionotropic glutamate receptors in hippocampus and striatum of aged Long–Evans rats: relationship to spatial learning

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

Place navigation impaired in rats with hippocampal lesions

1982 • 6,277 citations

Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat.

1979 • 1,970 citations

The physiology of excitatory amino acids in the vertebrate central nervous system

1987 • 1,718 citations

The neostriatal mosaic: multiple levels of compartmental organization

1992 • 1,450 citations

Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain

1985 • 1,294 citations

The Neostriatal Mosaic: Multiple Levels of Compartmental Organization in the Basal Ganglia

1992 • 1,005 citations

Differential effects of fornix and caudate nucleus lesions on two radial maze tasks: evidence for multiple memory systems

1989 • 1,000 citations

Anatomical organization of excitatory amino acid receptors and their pathways

1987 • 877 citations

Severity of spatial learning impairment in aging: Development of a learning index for performance in the Morris water maze.

2015 • 856 citations

The neostriatal mosaic: compartmentalization of corticostriatal input and striatonigral output systems

1984 • 815 citations

Severity of spatial learning impairment in aging: Development of a learning index for performance in the Morris water maze.

1993 • 653 citations

Amino acid neurotransmitters and their pathways in the mammalian central nervous system

1983 • 646 citations

Double dissociation of fornix and caudate nucleus lesions on acquisition of two water maze tasks: Further evidence for multiple memory systems.

1992 • 561 citations

Biochemical evidence for glutamate as neurotransmitter in corticostriatal and corticothalamic fibres in rat brain

1981 • 547 citations

The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro

1992 • 545 citations

Mosaic distribution of opiate receptors, parafascicular projections and acetylcholinesterase in rat striatum

1981 • 535 citations

Double dissociation of fornix and caudate nucleus lesions on acquisition of two water maze tasks: Further evidence for multiple memory systems.

1992 • 514 citations

The distribution of [3H]kainic acid binding sites in rat CNS as determined by autoradiography

1982 • 481 citations

Spatial memory deficit in senescent rats.

1980 • 479 citations

Plasticity of Hippocampal Circuitry in Alzheimer's Disease

1985 • 457 citations

Spatial learning and memory processes: the search for their neurobiological mechanisms in the rat

1988 • 426 citations

Neostriatal projections from individual cortical fields conform to histochemically distinct striatal compartments in the rat

1986 • 404 citations

An evaluation of spatial information processing in aged rats.

1987 • 353 citations

Antagonism of cortical excitation of striatal neurons by glutamic acid diethyl ester: Evidence for glutamic acid as an excitatory transmitter in the rat striatum

1976 • 343 citations

Degenerative Changes in Forebrain Cholinergic Nuclei Correlate with Cognitive Impairments in Aged Rats

1989 • 335 citations

Normal aging: regionally specific changes in hippocampal synaptic transmission

1994 • 332 citations

Impaired synaptic potentiation processes in the hippocampus of aged, memory-deficient rats

1978 • 298 citations

Progressive decline in spatial learning and integrity of forebrain cholinergic neurons in rats during aging

1992 • 294 citations

Physiological compensation for loss of afferent synapses in rat hippocampal granule cells during senescence.

1980 • 285 citations

Kainate binding sites in the hippocampal mossy fibers: Localization and plasticity

1987 • 280 citations

Caudate nucleus and memory for egocentric localization

1988 • 256 citations

Age‐related loss of axospinous synapses formed by two afferent systems in the rat dentate gyrus as revealed by the unbiased stereological dissector technique

1992 • 248 citations

Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys

1991 • 234 citations

Loss of perforated synapses in the dentate gyrus: morphological substrate of memory deficit in aged rats.

1986 • 231 citations

Age-related decreases of the N-methyl-d-aspartate receptor complex in the rat cerebral cortex and hippocampus

1991 • 212 citations

Age-dependent alterations in hippocampal synaptic plasticity: Relation to memory disorders

1988 • 204 citations

Behavioral effects of MK-801 mimic deficits associated with hippocampal damage

1989 • 190 citations

Impaired Monosynaptic Potentiation in in Vitro Hippocampal Slices From Aged, Memory-deficient Rats

1977 • 181 citations

The Hippocampus as a Model for Studying Anatomical Plasticity in the Adult Brain

1975 • 172 citations

Hippocampal plasticity induced by primed burst, but not long‐term potentiation, stimulation is impaired in area CA1 of aged fischer 344 rats

1993 • 170 citations

Region‐specific age effects on AMPA sensitivity: Electrophysiological evidence for loss of synaptic contacts in hippocampal field CA1

1992 • 158 citations

Evidence that the commissural, associational and septal projections of the regio inferior of the hippocampus arise from the same neurons

1980 • 154 citations

Pharmacological and anatomical evidence of selective μ, δ, and χ opioid receptor binding in rat brain

1986 • 151 citations

Age-related changes in excitatory amino acid receptors in two mouse strains

1993 • 143 citations

Spatial performance correlates with in vitro potentiation in young and aged Fischer 344 rats

1991 • 127 citations

Decrease in the number of synapses in the senescent brain: A quantitative electron microscopic analysis of the dentate gyrus molecular layer in the rat

1976 • 119 citations

Autoradiographic Characterization and Localization of Quisqualate Binding Sites in Rat Brain Using the Antagonist [³H]6‐Cyano‐7‐Nitroquinoxaline‐2,3‐Dione: Comparison with (R,S)‐[³H]α‐Amino‐3‐Hydroxy‐5‐Methyl‐4‐Isoxazolepropionic Acid Binding Sites

1990 • 103 citations

Partial deafferentation of neurons in the dentate gyrus of the senescent rat

1977 • 102 citations

Role of the caudate nucleus in spatial orientation of rats.

1969 • 99 citations

Synaptic localization of striatal NMDA, quisqualate and kainate receptors

1989 • 87 citations

Hippocampal 3H-CPP binding and spatial learning deficits in aged rats

1990 • 81 citations

In vitro autoradiography of hippocampal excitatory amino acid binding in aged Fischer 344 rats: Relationship to performance on the Morris water maze.

1992 • 80 citations

Neurobiological substrates of behavioral decline: Models and data analytic strategies for individual differences in aging

1996 • 79 citations

Influence of age on NMDA receptor complex in rat brain studied by in vitro autoradiography.

1990 • 76 citations

Decreased density, but not number, N-methyl-D-aspartate, glycine and phencyclidine binding sites in hippocampus of senescent rats

1990 • 70 citations

Reduced density of NMDA receptors and increased sensitivity to dizocilpine-induced learning impairment in aged rats

1992 • 68 citations

In vitro autoradiography of hippocampal excitatory amino acid binding in aged Fischer 344 rats: Relationship to performance on the Morris water maze.

1992 • 67 citations

Kainate receptors in the rat hippocampus: a distribution and time course of changes in response to unilateral lesions of the entorhinal cortex

1990 • 65 citations

The Sharpey‐Schafer Prize Lecture. The mechanism of induction of NMDA receptor‐dependent long‐term potentiation in the hippocampus

1992 • 61 citations

Effects of aging on NMDA and MK801 binding sites in mice

1993 • 59 citations

Is senile dementia of the Alzheimer type associated with hippocampal plasticity?

1988 • 56 citations

Decreased glutamate release correlates with elevated dynorphin content in the hippocampus of aged rats with spatial learning deficits

1991 • 55 citations

Volumes of the components of the hippocampus in the aging F344 rat

1987 • 55 citations

Excitatory amino acid action on the release of brain neurotransmitters and neuromodulators: Biochemical studies

1993 • 53 citations

Selective reduction of hippocampal dentate frequency potentiation in aged rats with impaired place learning

1994 • 42 citations

Effect of age on ?-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) binding sites in the rat brain studied by in vitro autoradiography

1991 • 41 citations

L-Glutamate specific [3H] kainic acid binding in the rat neostriatum after degeneration of the cortico-striatal pathway

1979 • 35 citations

Age-related deterioration of long-term potentiation in the CA3 and CA1 regions of hippocampal slices from the senescence-accelerated mouse

1990 • 26 citations

Influence of age on N‐methyl‐D‐aspartate antagonist binding sites in the rat brain studied by in vitro autoradiography

1991 • 25 citations

Alterations in [³H]‐kainate receptor binding in the hippocampal formation of aged long‐evans rats

1993 • 25 citations

Transneuronal changes in the lesioned entorhinal—hippocampal system

1993 • 23 citations