Comparison of Effects of Transforming Growth Factor-Beta and Cyclosporin A on Antigen-Presenting Cells of Blood and Epidermis

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

1986 • 1,617 citations

Transforming Growth Factor-β: Biological Function and Chemical Structure

1986 • 1,198 citations

Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro.

1985 • 1,141 citations

Expression and secretion of type beta transforming growth factor by activated human macrophages.

1987 • 981 citations

Migration and maturation of Langerhans cells in skin transplants and explants.

1990 • 663 citations

Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha.

1987 • 497 citations

Inhibition of cytokine production by cyclosporin A and transforming growth factor beta.

1987 • 466 citations

The Effects of Cyclosporin A on the Immune System

1985 • 442 citations

Transforming growth factor-beta is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation.

1988 • 392 citations

Cultured Human Langerhans Cells Resemble Lymphoid Dendritic Cells in Phenotype and Function

1989 • 376 citations

Transforming growth factor-beta 1 modulates the expression of class II histocompatibility antigens on human cells.

1988 • 298 citations

Transforming growth factor beta is a potent inhibitor of interleukin 1 (IL-1) receptor expression: proposed mechanism of inhibition of IL-1 action.

1990 • 229 citations

Human Epidermal Langerhans Cells Undergo Profound Morphologic and Phenotypical Changes During In Vitro Culture

1990 • 210 citations

Low-dose cyclosporin A in severe psoriasis. A double-blind study

1988 • 187 citations

In vitro evidence that Langerhans cells can adopt two functionally distinct forms capable of antigen presentation to T lymphocytes.

1989 • 177 citations

Transforming growth factor-beta inhibits the generation of cytotoxic T cells in virus-infected mice.

1989 • 164 citations

AUTOIMMUNITY AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION A STUDY OF 53 LONG-TERM-SURVIVING PATIENTS

1988 • 131 citations

Psoriatic Epidermal Cells Demonstrate Increased Numbers and Function of Non-Langerhans Antigen-presenting Cells

1989 • 105 citations

Functional Dichotomy between Langerhans Cells that Present Antigen to Naive and to Memory/Effector T Lymphocytes

1990 • 104 citations

Quantitation of Surface Antigens on Cultured Murine Epidermal Langerhans Cells: Rapid and Selective Increase in the Level of Surface MHC Products

1988 • 103 citations

Transforming growth factors type β1 and β2 suppress rat astrocyte autoantigen presentation and antagonize hyperinduction of class II major histocompatibility complex antigen expression by interferon-γ and tumor necrosis factor-α

1990 • 99 citations

Intralesional cyclosporine in the treatment of psoriasis

1990 • 99 citations

Cyclosporine inhibits macrophage-mediated antigen presentation.

1986 • 95 citations

Human epidermal Langerhans cells cointernalize by receptor-mediated endocytosis "nonclassical" major histocompatibility complex class I molecules (T6 antigens) and class II molecules (HLA-DR antigens).

1987 • 92 citations

The effect of cyclosporine on epidermal cells. I. Cyclosporine inhibits accessory cell functions of epidermal Langerhans cells in vitro.

1988 • 87 citations

EVIDENCE THAT CYCLOSPORINE INHIBITS CELL-MEDIATED IMMUNITY PRIMARILY AT THE LEVEL OF THE T LYMPHOCYTE RATHER THAN THE ACCESSORY CELL

1988 • 64 citations

Transforming growth factor beta 1 has differential effects on B cell proliferation and activation antigen expression.

1990 • 60 citations

Effectiveness of cyclosporine treatment in severe psoriasis: A clinical and immunologic study

1989 • 58 citations

Suppression of immune cell function in vitro by recombinant human transforming growth factor-β

1988 • 48 citations

Enhancement by various cytokines or 2-beta-mercaptoethanol of Ia antigen expression on Langerhans cells in skin from normal aged and young mice. Effect of cyclosporine A.

1989 • 46 citations

INHIBITION OF THE ACCESSORY FUNCTION OF MURINE MACROPHAGES IN VITRO BY CYCLOSPORINE

1985 • 40 citations

Stimulation of T cells by autologous mononuclear leukocytes and epidermal cells in psoriasis

1986 • 34 citations

MACROPHAGES AS TARGETS FOR INHIBITION BY CYCLOSPORINE

1989 • 31 citations

THE USE OF RANITIDINE IN BONE MARROW TRANSPLANTATION

1988 • 30 citations

BLOCKING OF ACQUISITION AND PRESENTATION OF ANTIGEN BY DENDRITIC CELLS WITH CYCLOSPORINE

1988 • 30 citations

SENSITIVITY OF VEILED (DENDRITIC) CELLS TO CYCLOSPORINE

1986 • 29 citations

INHIBITION OF HUMAN MONOCYTE ANTIGEN PRESENTATION, BUT NOT HLA-DR EXPRESSION, BY CYCLOSPORINE

1987 • 25 citations

Cyclosporine affects the function of antigen-presenting cells.

1986 • 24 citations

IMMUNOTOXINS FOR EX VIVO MARROW PURGING IN AUTOLOGOUS BONE MARROW TRANSPLANTATION FOR ACUTE NONLYMPHOCYTIC LEUKEMIA

1988 • 22 citations

Autoantibodies to each protein fraction extracted from cerebral endothelial cell membrane in the sera of patients with multiple sclerosis

1989 • 20 citations

Cyclosporin-A inhibits IL-2 production by all human T-cell clones having this function, independent of the phenotype or the coexpression of cytolytic activity

1986 • 15 citations

INHIBITION OF ALLOANTIGEN PRESENTATION BY CYCLOSPORINE

1990 • 9 citations

In vitro and in vivo action of cyclosporin A on the induction of human interleukin-2 receptor alpha and beta chains.

1989 • 9 citations

INHIBITOIN OF ANTIGEN-SPECIFIC ACTIVATION OF AN L3T4+ T CELL LINE BY CYCLOSPORINE WITH MAINTENANCE OF MACROPHAGE-MEDIATED ANTIGEN PRESENTATION1

1988 • 9 citations