Use of Plasma Pharmacokinetics to Predict and Prevent Methotrexate Toxicity

Adjuvant Methotrexate and Citrovorum-Factor Treatment of Osteogenic Sarcoma

1974 • 484 citations

Recent advances in the chemotherapy of metastatic osteogenic sarcoma

1972 • 276 citations

7-Hydroxymethotrexate as a urinary metabolite in human subjects and rhesus monkeys receiving high dose methotrexate.

1976 • 256 citations

Threshold Methotrexate Concentration for In Vivo Inhibition of DNA Synthesis in Normal and Tumorous Target Tissues

1973 • 240 citations

The reversal of methotrexate cytotoxicity to mouse bone marrow cells by leucovorin and nucleosides.

1976 • 163 citations

Phase I study of high doses of methotrexate with citrovorum factor in patients with lung cancer

1972 • 126 citations

Competitive protein binding assay for methotrexate.

1975 • 100 citations

Continuous infusion of methotrexate in children with acute leukemia

1967 • 89 citations

Enzymatic Cleavage of Methotrexate provides a Method for Prevention of Drug Toxicity

1972 • 67 citations