IL‐10 mediates immunosuppression following primary infection with Toxoplasma gondii in mice

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

1982 • 11,668 citations

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 • 1,950 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

Interferon-γ: the Major Mediator of Resistance Against Toxoplasma gondii

1988 • 1,150 citations

Interleukin-12 and its role in the generation of TH1 cells

1993 • 869 citations

Regulation of Immunity to Parasites by T Cells and T Cell-Derived Cytokines

1992 • 843 citations

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

1993 • 837 citations

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

1992 • 762 citations

IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages.

1992 • 709 citations

Expression of Interleukin-10 Activity by Epstein-Barr Virus Protein BCRF1

1990 • 539 citations

Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis.

1991 • 528 citations

IL-10 inhibits human T cell proliferation and IL-2 production.

1992 • 491 citations

IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function.

1992 • 375 citations

Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection.

1992 • 364 citations

Importance of endogenous IFN-gamma for prevention of toxoplasmic encephalitis in mice.

1989 • 355 citations

Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-alpha and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation.

1993 • 345 citations

Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection.

1994 • 290 citations

Regulation and biological function of helminth-induced cytokine responses

1991 • 260 citations

Interleukin‐4 and interleukin‐10 inhibit nitric oxide‐dependent macrophage killing of Candida albicans

1993 • 260 citations

Infection with Schistosoma mansoni alters Th1/Th2 cytokine responses to a non-parasite antigen.

1992 • 256 citations

Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative responses by nitric oxide and prostaglandins.

1993 • 249 citations

Interleukin-12 enhances murine survival against acute toxoplasmosis

1994 • 203 citations

Nitric oxide mediates suppression of T cell responses in murine Trypanosoma brucei infection

1992 • 136 citations

In vivo recombinant interleukin 2 administration enhances survival against a lethal challenge with Toxoplasma gondii.

1985 • 131 citations

Mitogen- and antigen-specific proliferation of T cells in murine toxoplasmosis is inhibited by reactive nitrogen intermediates

1994 • 116 citations

Antigen-specific CD8+ T cell clone protects against acute Toxoplasma gondii infection in mice.

1994 • 109 citations

Kinetics of cytokine mRNA production in the brains of mice with progressive toxoplasmic encephalitis

1992 • 109 citations

Kinetics of induction and molecular size of mRNAs encoding human interleukin-2 and γ-interferon

1982 • 104 citations

Trypanosoma cruzi-induced suppression of IL-2 production. II. Evidence for a role for suppressor cells.

1988 • 92 citations

Immune Response of Mice to Ingested Toxoplasma gondii: A Model of Toxoplasma Infection Acquired by Ingestion

1984 • 84 citations

Induction of macrophage nitric oxide production by interferon‐γ and tumor necrosis factor‐α is enhanced by interleukin‐10

1993 • 83 citations

Image analysis for all

1990 • 65 citations

Blastogenic response of Toxoplasma-infected mouse spleen cells to T- and B-cell mitogens.

1975 • 58 citations

Role of IL-10 on antigen-presenting cell function for schistosomal egg-specific monoclonal T helper cell responses in vitro and in vivo.

1993 • 52 citations

Impairment of the cellular immune response in acute murine toxoplasmosis: regulation of interleukin 2 production and macrophage-mediated inhibitory effects

1994 • 47 citations

Induction of antigen-specific human cytotoxic T cells by Toxoplasma gondii.

1990 • 47 citations

Temporal differences in the expression of mRNA for IL‐10 and IFN‐γ in the brains and spleens of C57BL/10 mice infected with Toxoplasma gondii

1994 • 41 citations

Demonstration of T-Cell dysfunction during acute toxoplasma infection

1986 • 36 citations

Lymphocyte anergy specific to Toxoplasma gondii antigens in a baby with congenital toxoplasmosis.

1985 • 34 citations

Presence of gamma interferon in human acute and congenital toxoplasmosis

1990 • 27 citations

Spleen and lymph node cell populations, In vitro cell proliferation and interferon‐y production during the primary immune response to Toxoplasma gondii

1986 • 22 citations

INTERLEUKIN 2: A 10-YEAR PERSPECTIVE

1988 • 20 citations

Macrophage-mediated suppression of immune responses in Toxoplasma-infected mice

1987 • 15 citations

Toxoplasma gondii: Decreased resistance to intracellular bacteria in mice

1983 • 12 citations