Cyclic adenosine monophosphate acts synergistically with dexamethasone to inhibit the entrance of cultured adult rat hepatocytes into S‐phase: With a note on the use of nucleolar and extranucleolar [³H]‐thymidine labelling patterns to determine rapid changes in the rate of onset of DNA replication

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

PROTEIN SERINE/THREONINE KINASES

1987 • 1,457 citations

Cell population kinetics in the intestinal epithelium of the mouse

1959 • 1,446 citations

A Restriction Point for Control of Normal Animal Cell Proliferation

1974 • 1,389 citations

Functional identity of proliferating cell nuclear antigen and a DNA polymerase-δ auxiliary protein

1987 • 1,074 citations

[11] Measurement of growth and viability of cells in culture

1979 • 517 citations

The biology of cell reproduction

1985 • 375 citations

Kinetic analysis of regulatory events in G1 leading to proliferation or quiescence of Swiss 3T3 cells.

1985 • 370 citations

DNA synthesis in primary cultures of adult rat hepatocytes in a defined medium: Effects of epidermal growth factor, insulin, glucagon, and cyclic‐AMP

1981 • 345 citations

Caffeine-Induced Uncoupling of Mitosis from the Completion of DNA Replication in Mammalian Cells

1986 • 328 citations

Slow Transitions and Hysteretic Behavior in Enzymes

1979 • 292 citations

Changes in the nuclear distribution of cyclin (PCNA) but not its synthesis depend on DNA replication.

1985 • 284 citations

Interaction of Glucocorticoids with Glucagon and Epinephrine in the Control of Gluconeogenesis and Glycogenolysis in Liver and of Lipolysis in Adipose Tissue

1972 • 275 citations

α1-Adrenergic effects and liver regeneration

1987 • 190 citations

Regulation of hepatic growth

1986 • 173 citations

Increases in rat liver cyclic AMP concentrations prior to the initiation of DNA synthesis following partial hepatectomy or hormone infusion

1972 • 160 citations

Multihormonal regulation of phosphoenolpyruvate carboxykinase-chloramphenicol acetyltransferase fusion genes. Insulin's effects oppose those of cAMP and dexamethasone.

1987 • 155 citations

Adrenergic antagonists, and a possible link between the increase in cyclic adenosine 3′,5′‐monophosphate and DNA synthesis during liver regeneration

1973 • 145 citations

Thyrotropin and dibutyryl cyclic AMP increase levels of c-myc and c-fos mRNAs in cultured rat thyroid cells.

1986 • 140 citations

Somatic genetic analysis of cyclic AMP action: Selection of unresponsive mutants

1975 • 132 citations

Activation of protein kinase isozymes by cyclic nucleotide analogs used singly or in combination

1985 • 115 citations

Distribution of DNA replicator sites in mammalian nuclei after different methods of cell synchronization

1970 • 113 citations

Protein phosphorylation

1982 • 104 citations

Regulation of Messenger Ribonucleic Acid Levels for Five Urea Cycle Enzymes in Cultured Rat Hepatocytes. Requirements for Cyclic Adenosine Monophosphate, Glucocorticoids, and Ongoing Protein Synthesis

1988 • 98 citations

Changes in hormone responsiveness and cyclic AMP metabolism in rat hepatocytes during primary culture and effects of supplementing the medium with insulin and dexamethasone

1984 • 98 citations

Hormonal control of liver regeneration

1974 • 95 citations

Calcium, cyclic AMP and protein kinase C ? partners in mitogenesis

1987 • 86 citations

Hormonal regulation of DNA synthesis in primary cultures of adult rat hepatocytes

1981 • 86 citations

Synergistic stimulation of DNA synthesis by cyclic AMP derivatives and growth factors in mouse 3T3 cells

1982 • 78 citations

Molecules involved in proliferation of normal and cancer cells: presidential address.

1987 • 76 citations

Norepinephrine modulates the growth‐inhibitory effect of transforming growth factor‐beta in primary rat hepatocyte cultures

1988 • 75 citations

Binding proteins for cyclic AMP in mammalian tissues

1981 • 72 citations

Induction of cyclic AMP synthesis by forskolin is followed by a reduction in the expression of c‐myc messenger RNA and inhibition of ³H‐thymidine incorporation in human fibroblasts

1989 • 72 citations

The cell cycle of mammalian cells.

1969 • 68 citations

Cyclic AMP dependent regulation of mitosis in human lymphoid cells

1974 • 67 citations

DNA synthesis in rat hepatocytes: Inhibition by a platelet factor and stimulation by an endogenous factor

1985 • 66 citations

Individual nuclei in polykaryons can control cyclin distribution and DNA synthesis.

1985 • 63 citations

Regulation of dog thyroid epithelial cell cycle by forskolin, an adenylate cyclase activator

1987 • 62 citations

Dexamethasone and dimethylsulfoxide as distinct regulators of growth and differentiation of cultured suckling rat hepatocytes

1986 • 60 citations

[11] Use of synergistic pairs of site-selective cAMP analogs in intact cells

1988 • 60 citations

Bidirectional concentration-dependent effects of glucagon and dibutyryl cyclic AMP on DNA synthesis in cultured adult rat hepatocytes

1983 • 60 citations

The involvement of cyclic AMP-dependent protein kinase(s) in the induction of ornithine decarboxylase in the regenerating rat liver and in the adrenal gland after unilateral adrenalectomy

1977 • 54 citations

The expression of cAMP-dependent protein kinase subunits is differentially regulated during liver regeneration

1989 • 53 citations

A simple method for the preparation of cell cultures for ultrastructural investigation.

1981 • 44 citations

Modulation of the mitogenic response of an epidermal growth factor‐dependent keratinocyte cell line by dexamethasone, insulin, and transforming growth factor‐β

1988 • 41 citations

Cell cycle parameters of adult rat hepatocytes in a defined medium. A note on the timing of nucleolar DNA replication

1987 • 40 citations

Properties of protein kinase and adenylate cyclase‐deficient variants of a macrophage‐like cell line

1979 • 38 citations

Characterization of the inhibitory effect of glucocorticoids on the DNA replication of adult rat hepatocytes growing at various cell densities

1989 • 38 citations

Biochemistry of the cell cycle

1987 • 35 citations

Reversible arrest of Chinese hamster V79 cells in G2 by dibutyryl cyclic AMP

1976 • 34 citations

Late S phase cells (Chinese hamster ovary) induce early S phase DNA labeling patterns in G1 phase nuclei.

1978 • 33 citations

A simple medium for the study of hepatocyte growth in culture under defined conditions

1988 • 33 citations

The stimulation of the initiation of DNA synthesis by fibroblast growth factor in swiss 3T3 cells: Interactions with hormones during the pre‐replicative phase

1980 • 33 citations

cAMP‐mediated growth inhibition of a B‐lymphoid precursor cell line Reh is associated with an early transient delay in G₂/M, followed by an accumulation of cells in G₁

1988 • 32 citations

Cellular mechanisms regulating proliferation.

1988 • 26 citations

Thyrotropin and cyclic AMP regulation of ras proto‐oncogene expression in cultured thyroid cells

1986 • 25 citations

Molecular biology of liver regeneration

1986 • 22 citations

Measurement of adenylate cyclase activity by competitive binding to the free regulatory moiety of protein kinase I

1980 • 16 citations