Pathophysiology of motor fluctuations in Parkinson's disease

THE BASAL GANGLIA: FOCUSED SELECTION AND INHIBITION OF COMPETING MOTOR PROGRAMS

1996 • 2,415 citations

Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop

1995 • 2,101 citations

The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism

1994 • 1,352 citations

Dopamine Dependency of Oscillations between Subthalamic Nucleus and Pallidum in Parkinson's Disease

2001 • 1,119 citations

Functional anatomy of the basal ganglia

2002 • 930 citations

Distribution of striatonigral and striatopallidal peptidergic neurons in both patch and matrix compartments: an in situ hybridization histochemistry and fluorescent retrograde tracing study

1988 • 649 citations

Abnormal spontaneous activity of globus pallidus neurons in monkeys with MPTP-induced parkinsonism

1991 • 641 citations

Drug addiction: A model for the molecular basis of neural plasticity

1993 • 548 citations

Motor fluctuations in Parkinson's disease: Central pathophysiological mechanisms, part II

1988 • 359 citations

Abnormal influences of passive limb movement on the activity of globus pallidus neurons in parkinsonian monkeys

1988 • 338 citations

Basal ganglia motor control. III. Pallidal ablation: normal reaction time, muscle cocontraction, and slow movement

1991 • 321 citations

300-Hz subthalamic oscillations in Parkinson's disease

2003 • 245 citations

Activity of Pallidal and Striatal Tonically Active Neurons Is Correlated in MPTP-Treated Monkeys But Not in Normal Monkeys

2001 • 218 citations

Motor fluctuations in Parkinson's disease: Central pathophysiological mechanisms, Part I

1988 • 211 citations

Functional Mapping of Dorsal and Median Raphe 5‐Hydroxytryptamine Pathways in Forebrain of the Rat Using Microdialysis

1997 • 184 citations

Chronic Alterations in Dopaminergic Neurotransmission Produce a Persistent Elevation of ΔFosB‐like Protein(s) in both the Rodent and Primate Striatum

1996 • 180 citations

Synaptic organization of the striatum

1988 • 156 citations

Evidence for a dopaminergic innervation of the subthalamic nucleus in the rat

1997 • 152 citations

Risk factors for levodopa-induced dyskinesias in Parkinson's disease

1999 • 137 citations

Evidence for interconnections between the two segments of the globus pallidus in primates: a PHA-L anterograde tracing study

1990 • 137 citations

COMPLICATED RESPONSE FLUCTUATIONS IN PARKINSON'S DISEASE: RESPONSE TO INTRAVENOUS INFUSION OF LEVODOPA

1982 • 131 citations

Preproenkephalin mRNA expression in the caudate-putamen of MPTP monkeys after chronic treatment with the D2 agonist U91356A in continuous or intermittent mode of administration: comparison with l-DOPA therapy

1997 • 112 citations

D1 Dopamine Receptor Supersensitivity in the Dopamine-Depleted Striatum Animal Model of Parkinson’s Disease

2003 • 109 citations

Alterations in preproenkephalin and adenosine‐2a receptor mRNA, but not preprotachykinin mRNA correlate with occurrence of dyskinesia in normal monkeys chronically treated with <scp>l</scp>‐DOPA

2000 • 108 citations

Differential Regulation of Striatal Preproenkephalin and Preprotachykinin mRNA Levels in MPTP‐Lesioned Monkeys Chronically Treated with Dopamine D<scp>1</scp> or D<scp>2</scp> Receptor Agonists

1999 • 101 citations

LISURIDE INFUSION PUMP: A DEVICE FOR THE TREATMENT OF MOTOR FLUCTUATIONS IN PARKINSON'S DISEASE

1986 • 96 citations

Avoidance of dyskinesia

2004 • 93 citations

Effect of D1 and D2 agonists and antagonists on dyskinesia produced by L-dopa in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys.

1991 • 73 citations

Serotonin in the basal ganglia: functions and interactions with other neuronal pathways.

1981 • 73 citations

Patterns of gene expression and behavior induced by chronic dopamine treatments.

2000 • 56 citations

Impaired Reaching and Grasping After Focal Inactivation of Globus Pallidus Pars Interna in the Monkey

1999 • 55 citations

Changes of D1 and D2 dopamine receptor mRNA in the brains of monkeys lesioned with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: correction with chronic administration of L-3,4-dihydroxyphenylalanine.

1996 • 49 citations

Continuous or pulsatile chronic D2 dopamine receptor agonist (U91356A) treatment of drug-naive 4-phenyl-1,2,3,6-tetrahydropyridine monkeys differentially regulates brain D1 and D2 receptor expression: in situ hybridization histochemical analysis

1997 • 38 citations

Chronic treatment with small doses of cabergoline prevents dopa‐induced dyskinesias in parkinsonian monkeys

2003 • 36 citations

Continuous Dopaminergic Stimulation in Parkinson's Disease

1987 • 26 citations