3 Action of insulin on glucose metabolism in vivo

Glucose clamp technique: a method for quantifying insulin secretion and resistance.

1979 • 7,240 citations

The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous Catheterization

1981 • 1,728 citations

INFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT*

1959 • 1,674 citations

The theoretical bases of indirect calorimetry: A review

1988 • 1,536 citations

Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by¹³C Nuclear Magnetic Resonance Spectroscopy

1990 • 1,226 citations

Assessment of Insulin Sensitivityin Vivo*

1985 • 1,076 citations

Effect of fatty acids on glucose production and utilization in man.

1983 • 1,056 citations

Skeletal muscle metabolism is a major determinant of resting energy expenditure.

1990 • 879 citations

Liver and kidney metabolism during prolonged starvation

1969 • 840 citations

Cerebral Blood Flow and Metabolism

1994 • 779 citations

Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles

1964 • 729 citations

Dose-response characteristics for effects of insulin on production and utilization of glucose in man

1981 • 712 citations

Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects.

1980 • 665 citations

Glucose metabolism during leg exercise in man

1971 • 601 citations

Estimation of Endogenous Glucose Production During Hyperinsulinemic-Euglycemic Glucose Clamps: Comparison of Unlabeled and Labeled Exogenous Glucose Infusates

1987 • 548 citations

ON THE HORMONAL REGULATION OF CARBOHYDRATE METABOLISM; STUDIES WITH C14 GLUCOSE.

1963 • 540 citations

Regulation of Splanchnic and Peripheral Glucose Uptake by Insulin and Hyperglycemia in Man

1983 • 517 citations

Quantitation of Hepatic Glycogenolysis And Gluconeogenesis in Fasting Humans With ¹³ C NMR

1991 • 515 citations

Temperature regulation in man ? A theoretical study

1966 • 481 citations

THE QUANTITATIVELY MINOR ROLE OF CARBOHYDRATE IN OXIDATIVE METABOLISM BY SKELETAL MUSCLE IN INTACT MAN IN THE BASAL STATE. MEASUREMENTS OF OXYGEN AND GLUCOSE UPTAKE AND CARBON DIOXIDE AND LACTATE PRODUCTION IN THE FOREARM 12

1956 • 393 citations

THE CEREBRAL BLOOD FLOW IN MALE SUBJECTS AS MEASURED BY THE NITROUS OXIDE TECHNIQUE. NORMAL VALUES FOR BLOOD FLOW, OXYGEN UTILIZATION, GLUCOSE UTILIZATION, AND PERIPHERAL RESISTANCE, WITH OBSERVATIONS ON THE EFFECT OF TILTING AND ANXIETY 1

1949 • 367 citations

31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus.

1992 • 324 citations

Glucose-free fatty acid cycle operates in human heart and skeletal muscle in vivo.

1992 • 314 citations

Splanchnic and peripheral glucose and amino acid metabolism in diabetes mellitus

1972 • 312 citations

Skeletal muscle glycolysis, oxidation, and storage of an oral glucose load.

1988 • 305 citations

Natural Course of Insulin Resistance in Type I Diabetes

1986 • 301 citations

Contribution of Abnormal Muscle and Liver Glucose Metabolism to Postprandial Hyperglycemia in NIDDM

1990 • 300 citations

Effect of long chain triglyceride infusion on glucose metabolism in man

1982 • 299 citations

Insulin within islets is a physiologic glucagon release inhibitor.

1984 • 299 citations

Insulin transport across capillaries is rate limiting for insulin action in dogs.

1989 • 299 citations

Influence of hyperinsulinemia, hyperglycemia, and the route of glucose administration on splanchnic glucose exchange

1978 • 293 citations

Influence of Endogenous Insulin Secretion on Splanchnic Glucose and Amino Acid Metabolism in Man

1971 • 270 citations

Kinetics of glucose disposal in whole body and across the forearm in man.

1987 • 268 citations

Portal and Peripheral Vein Immunoreactive Insulin Concentrations Before and After Glucose Infusion

1970 • 245 citations

Glucoregulatory responses in normal and diabetic dogs recorded by a new tracer method

1971 • 244 citations

Liver Glycogen in Man –- the Effect of Total Starvation or a Carbohydrate-Poor Diet Followed by Carbohydrate Refeeding

1973 • 242 citations

Investigation of [18F]2-fluoro-2-deoxyglucose for the measure of myocardial glucose metabolism.

1978 • 221 citations

Quantitative Estimation of the Cori Cycle in the Human

1963 • 216 citations

Metabolic fate of extracted glucose in normal human myocardium.

1985 • 199 citations

Mechanism of increased gluconeogenesis in noninsulin-dependent diabetes mellitus. Role of alterations in systemic, hepatic, and muscle lactate and alanine metabolism.

1990 • 199 citations

Effects of insulin infusion on human skeletal muscle pyruvate dehydrogenase, phosphofructokinase, and glycogen synthase. Evidence for their role in oxidative and nonoxidative glucose metabolism.

1987 • 189 citations

Glucose uptake in human adipose tissue

1987 • 180 citations

STUDIES OF THE ROLE OF THE LIVER IN HUMAN CARBOHYDRATE METABOLISM BY THE VENOUS CATHETER TECHNIC. II. PATIENTS WITH DIABETIC KETOSIS, BEFORE AND AFTER THE ADMINISTRATION OF INSULIN 12

1949 • 172 citations

Determination of Krebs cycle metabolic carbon exchange in vivo and its use to estimate the individual contributions of gluconeogenesis and glycogenolysis to overall glucose output in man.

1987 • 167 citations

Insulin Dose-Response Characteristics for Suppression of Glycerol Release and Conversion to Glucose in Humans

1986 • 167 citations

Regulation of hepatic glucose metabolism in humans

1987 • 165 citations

Evidence for an important role of glucagon in the regulation of hepatic glucose production in normal man.

1977 • 161 citations

Non-steady state: error analysis of Steele's model and developments for glucose kinetics

1987 • 150 citations

Peripheral effects of insulin dominate suppression of fasting hepatic glucose production

1990 • 149 citations

HYPERGLYCEMIA INHIBITS GLUCOSE PRODUCTION IN MAN INDEPENDENT OF CHANGES IN GLUCOREGULATORY HORMONES

1978 • 148 citations

Demonstration of a dawn phenomenon in normal human volunteers

1984 • 139 citations

Effects of insulin on skeletal muscle glucose storage, oxidation, and glycolysis in humans

1990 • 139 citations

Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration.

1991 • 138 citations

Localization of Rate-Limiting Defect for Glucose Disposal in Skeletal Muscle of Insulin-Resistant Type I Diabetic Patients

1990 • 129 citations

Regulation of glycogen synthase and phosphorylase activities by glucose and insulin in human skeletal muscle.

1987 • 125 citations

Contribution to Postprandial Hyperglycemia and Effect on Initial Splanchnic Glucose Clearance of Hepatic Glucose Cycling in Glucose-Intolerant or NIDDM Patients

1991 • 125 citations

Influence of physiologic hyperglucagonemia on basal and insulin-inhibited splanchnic glucose output in normal man.

1976 • 124 citations

Abnormal meal carbohydrate disposition in insulin-dependent diabetes. Relative contributions of endogenous glucose production and initial splanchnic uptake and effect of intensive insulin therapy.

1984 • 120 citations

The Glucose Uptake of Human Adipose Tissue in Obesity

1971 • 118 citations

Continuous Subcutaneous Insulin Infusion Therapy Decreases Insulin Resistance in Type 1 Diabetes*

1984 • 114 citations

Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates

1987 • 109 citations

Mechanisms of Hyperglycemia-Induced Insulin Resistance in Whole Body and Skeletal Muscle of Type I Diabetic Patients

1992 • 106 citations

NET SPLANCHNIC GLUCOSE PRODUCTION IN NORMAL MAN AND IN VARIOUS DISEASE STATES 1

1950 • 106 citations

Effects of acute hyperglycemia on myocardial glycolytic activity in humans.

1990 • 105 citations

Acute effects of glucose-insulin-potassium infusion on myocardial substrates, coronary blood flow and oxygen consumption in man

1977 • 105 citations

Insulin, glucagon, and glucose as regulators of hepatic glucose uptake and production in vivo

1987 • 103 citations

Regulation of Net Hepatic Glucose Uptake In Vivo

1992 • 99 citations

Effect of Free Fatty Acids on Glucose Uptake and Nonoxidative Glycolysis across Human Forearm Tissues in the Basal State and during Insulin Stimulation*

1991 • 99 citations

Intraportal glucose delivery enhances the effects of hepatic glucose load on net hepatic glucose uptake in vivo.

1991 • 97 citations

Direct observation of glycogen synthesis in human muscle with 13C NMR.

1989 • 96 citations

Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog.

1980 • 94 citations

HEPATIC GLUCOSE OUTPUT AND HEPATIC INSULIN SENSITIVITY IN DIABETES MELLITUS

1951 • 90 citations

Total Cerebral Blood Flow And Metabolism

1965 • 87 citations

No accumulation of glucose in human skeletal muscle during euglycemic hyperinsulinemia

1988 • 85 citations

Myocardial Lipid and Carbohydrate Metabolism in Healthy, Fasting Men at Rest: Studies During Continuous Infusion of ³H‐Palmitate

1972 • 80 citations

STUDIES OF THE ROLE OF THE LIVER IN HUMAN CARBOHYDRATE METABOLISM BY THE VENOUS CATHETER TECHNIC. I. NORMAL SUBJECTS UNDER FASTING CONDITIONS AND FOLLOWING THE INJECTION OF GLUCOSE1

1949 • 78 citations

Differential Effects of Insulin on Splanchnic and Peripheral Glucose Disposal after an Intravenous Glucose Load in Man

1982 • 74 citations

Effects of Hyperglycemia on Glucose Production and Utilization in Humans: Measurement With [23H]-, [33H]-, and [614C]Glucose

1986 • 71 citations

Magnitude of Negative Arterial-Portal Glucose Gradient Alters Net Hepatic Glucose Balance in Conscious Dogs

1991 • 65 citations

Contribution of abnormal muscle and liver glucose metabolism to postprandial hyperglycemia in NIDDM

1990 • 65 citations

Cerebral blood flow and substrate utilization in insulin-treated diabetic subjects

1990 • 64 citations

Muscle Glycogen Synthesis and Disposition of Infused Glucose in Humans With Reduced Rates of Insulin-Mediated Carbohydrate Storage

1988 • 64 citations

D-[U-11C]glucose uptake and metabolism in the brain of insulin-dependent diabetic subjects

1990 • 59 citations

Effects of insulin at two dose levels on gluconeogenesis from alanine in fasting man

1980 • 57 citations

Differential effects of insulin therapy on hepatic and peripheral insulin sensitivity in Type 2 (non-insulin-dependent) diabetes

1982 • 57 citations

Insulin increases the maximum velocity for glucose uptake without altering the Michaelis constant in man. Evidence that insulin increases glucose uptake merely by providing additional transport sites.

1982 • 56 citations

Demonstration of a novel feedback mechanism between FFA oxidation from intracellular and intravascular sources

1991 • 55 citations

Facilitated transport of glucose from blood to brain in man and the effect of moderate hypoglycaemia on cerebral glucose utilization

1991 • 55 citations

Gut Exchange of Glucose and Lactate in Basal State and After Oral Glucose Ingestion in Postoperative Patients

1990 • 54 citations

A STUDY IN MAN OF CEREBRAL BLOOD FLOW AND CEREBRAL GLUCOSE, LACTATE AND PYRUVATE METABOLISM BEFORE AND AFTER EATING*

1959 • 52 citations

Effects of atropine and gastric inhibitory polypeptide on hepatic glucose uptake and insulin extraction in conscious dogs.

1985 • 52 citations

Dose-response relationship between lymph insulin and glucose uptake reveals enhanced insulin sensitivity of peripheral tissues

1992 • 52 citations

Mechanism for Underestimation of Isotopically Determined Glucose Disposal

1989 • 50 citations

Splanchnic and renal exchange of infused fructose in insulin-deficient type 1 diabetic patients and healthy controls.

1989 • 50 citations

Insulin resistance is a prominent feature of patients with pancreatogenic diabetes

1986 • 48 citations

Dynamics of Hepatic and Peripheral Insulin Effects Suggest Common Rate-Limiting Step In Vivo

1993 • 48 citations

Effects of small changes in glucagon on glucose production during a euglycemic, hyperinsulinemic clamp

1991 • 46 citations

Effects of Fasting on Plasma Glucose and Prolonged Tracer Measurement of Hepatic Glucose Output in NIDDM

1987 • 45 citations

Transient hepatic response to glucagon in man: role of insulin and hyperglycemia

1982 • 45 citations

Normal alanine-glucose relationships and their changes in diabetic patients before and after insulin treatment.

1979 • 41 citations

Insulin response of components of whole-body and muscle carbohydrate metabolism in humans

1988 • 37 citations

Insulin inhibition of overnight glucose production and gluconeogenesis from lactate in NIDDM

1989 • 36 citations

In vivo stimulation of the insulin receptor kinase in human skeletal muscle. Correlation with insulin-stimulated glucose disposal during euglycemic clamp studies.

1991 • 35 citations

Localization of rate-limiting defect for glucose disposal in skeletal muscle of insulin-resistant type I diabetic patients

1990 • 35 citations

Hepatic and Extrahepatic Responses to Insulin in NIDDM and Nondiabetic Humans: Assessment in Absence of Artifact Introduced by Tritiated Nonglucose Contaminants

1990 • 32 citations

Effect of intraportal and peripheral insulin on glucose turnover and recycling in diabetic dogs

1983 • 30 citations

Effects of hyperglycemia on glucose production and utilization in humans. Measurement with [23H]-, [33H]-, and [614C]glucose

1986 • 28 citations

Insulin dose-response characteristics for suppression of glycerol release and conversion to glucose in humans

1986 • 28 citations

Contribution to postprandial hyperglycemia and effect on initial splanchnic glucose clearance of hepatic glucose cycling in glucose-intolerant or NIDDM patients

1991 • 28 citations

Dynamics of hepatic and peripheral insulin effects suggest common rate-limiting step in vivo

1993 • 25 citations

The Role of Fatty Acid and of Hormones in the Determination of Myocardial Carbohydrate Metabolism in Healthy Fasting Men

1973 • 24 citations

Mechanisms of hyperglycemia-induced insulin resistance in whole body and skeletal muscle of type I diabetic patients

1992 • 24 citations

Underestimation of glucose turnover corrected with high-performance liquid chromatography purification of [6-3H]glucose

1990 • 23 citations

Physiology of glucagon.

1981 • 23 citations

Mechanism for underestimation of isotopically determined glucose disposal

1989 • 22 citations

INSULIN INFUSION INTO THE PORTAL AND PERIPHERAL CIRCULATIONS OF UNANAESTHETIZED DOGS

1978 • 22 citations

Muscle glycogen synthesis and disposition of infused glucose in humans with reduced rates of insulin-mediated carbohydrate storage

1988 • 21 citations

No evidence for isotope discrimination of tritiated glucose tracers in measurements of glucose turnover rates in man

1990 • 21 citations

Gut exchange of glucose and lactate in basal state and after oral glucose ingestion in postoperative patients

1990 • 16 citations

Comparison of extracellular and net glucose oxidation measured isotopically and by indirect calorimetry during high and low glucose turnover

1991 • 15 citations

Endocrine physiology II

1977 • 15 citations

Measurement of lactate formation from glucose using [6-3H]- and [6-14C]glucose in humans.

1990 • 15 citations

COMPARISON OF THE EFFECT OF INTRAPORTAL AND INTRAVENOUS INFUSION OF INSULIN ON BLOOD GLUCOSE AND FREE FATTY ACIDS IN PERIPHERAL VENOUS BLOOD OF MAN

1974 • 15 citations

Hepatic and extrahepatic responses to insulin in NIDDM and nondiabetic humans. Assessment in absence of artifact introduced by tritiated nonglucose contaminants

1990 • 14 citations

Relationship among Peripheral Glucose Uptake, Oxygen Consumption, and Glucose Turnover in Postabsorptive Man*

1984 • 13 citations

Effects of fasting on plasma glucose and prolonged tracer measurement of hepatic glucose output in NIDDM

1987 • 12 citations

Magnitude of negative arterial-portal glucose gradient alters net hepatic glucose balance in conscious dogs

1991 • 12 citations

Hepatic Denervation Alters the Disposition of an Enteral Glucose Load in Conscious Dogs

1991 • 11 citations

Regulation Of Net Hepatic Glucose Uptake In Vivo

1992 • 6 citations