Biochemical pharmacology of Gabaergic agonists

Handbook of Psychopharmacology

1988 • 2,778 citations

Benzodiazepine Receptor: Demonstration in the Central Nervous System

1977 • 1,705 citations

Chemical Nature of Synaptic Transmission in Vertebrates

1974 • 1,613 citations

GABA in nervous system function

1977 • 1,087 citations

Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the cat

1971 • 685 citations

The action of γ-Aminobutyric acid on cortical neurones

1967 • 612 citations

THE UPTAKE OF [³H]GABA BY SLICES OF RAT CEREBRAL CORTEX

1968 • 543 citations

Epilepsy and γ-Aminobutyric Acid-Mediated Inhibition

1975 • 491 citations

γ‐VINYL GABA (4‐amino‐hex‐5‐enoic acid), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA‐T: EFFECTS ON BRAIN GABA METABOLISM IN MICE¹

1977 • 472 citations

Mechanism of Action of Benzodiazepines

1976 • 437 citations

A study of the action of picrotoxin on the inhibitory neuromuscular junction of the crayfish

1969 • 414 citations

Biochemical-physiology correlations in studies of the γ-aminobutyric acid system

1968 • 408 citations

EFFECTS OF DI‐n‐PROPYLACETATE, AN ANTICONVULSIVE COMPOUND, ON GABA METABOLISM¹

1969 • 394 citations

Influences ions, enzymes, and detergents on gamma-aminobutyric acid-receptor binding in synaptic membranes of rat brain.

1977 • 384 citations

Muscimol binding in rat brain: Association with synaptic GABA receptors

1978 • 377 citations

Studies of the uptake of3H-GABA and [3H]glycine in slices and homogenates of rat brain and spinal cord by electron microscopic autoradiography

1972 • 371 citations

FREE γ-AMINOBUTYRIC ACID IN BRAIN

1950 • 362 citations

The pharmacology of amino acids related to gamma-aminobutyric acid.

1965 • 333 citations

The fine structural localization of glutamate decarboxylase in synaptic terminals of rodent cerebellum

1974 • 332 citations

Sodium Valproate

1977 • 318 citations

On the source of gaba-containing terminals in the substantia nigra. Electron microscopic autoradiographic and biochemical studies

1973 • 286 citations

Effect of sodium n-dipropylacetate on audiogenic seizures and brain γ-aminobutyric acid level

1973 • 285 citations

Chlordiazepoxide selectively augments GABA action in spinal cord cell cultures

1977 • 280 citations

Interaction of barbiturates with dihydropicrotoxinin binding sites related to the GABA receptor-ionophore system

1978 • 274 citations

γ-aminobutyric acid and nervous system function—A perspective

1974 • 269 citations

STRUCTURE AND BIOLOGICAL ACTIVITY OF A SERIES OF CONFORMATIONALLY RESTRICTED ANALOGUES OF GABA

1975 • 267 citations

Sodium Di‐N‐Propylacetate (DPA) in the Treatment of Epilepsy:A Review

1975 • 255 citations

The effect of diazepam on spinal cord activities: Possible sites and mechanisms of action

1974 • 246 citations

The characterisation of [3H]GABA uptake into the satellite glial cells of rat sensory ganglia

1974 • 246 citations

THE EFFECT OF 4‐AMINO HEX‐5‐YNOIC ACID (γ‐ACETYLENIC GABA, γ‐ETHYNYL GABA) A CATALYTIC INHIBITOR OF GABA TRANSAMINASE, ON BRAIN GABA METABOLISM IN VIVO

1977 • 216 citations

Neuropharmacology of Amino Acid Inhibitory Transmitters

1978 • 212 citations

Central actions of ibotenic acid and muscimol

1968 • 208 citations

Effects of drugs on γ-aminobutyric acid receptors, uptake, release and synthesis in vitro

1978 • 205 citations

The effect of bicuculline upon synaptic inhibition in the cerebral and cerebellar cortices of the cat

1971 • 193 citations

Central GABA receptor agonists: Comparison of muscimol and baclofen

1976 • 182 citations

Active-site-directed irreversible inhibition of rat brain 4-aminobutyrate aminotransferase by ethanolamine O-sulphate in vitro and in vivo

1972 • 178 citations

Antagonism between Lioresal and substance P in rat spinal cord

1975 • 178 citations

Pentobarbital selectively enhances GABA-mediated post-synaptic inhibition in tissue cultured mouse spinal neurons

1976 • 177 citations

STRUCTURE‐ACTIVITY STUDIES ON THE INHIBITION OF GABA BINDING TO RAT BRAIN MEMBRANES BY MUSCIMOL AND RELATED COMPOUNDS

1978 • 176 citations

Anticonvulsant action of ethanolamine-O-sulphate and di-n-propylacetate and the metabolism of γ-aminobutyric acid (GABA) in mice with audiogenic seizures

1976 • 175 citations

Stereospecificity and structure-activity requirements of GABA receptor binding in rat brain

1977 • 165 citations

OCCLUSION AND METABOLISM OF γ‐AMINOBUTYRIC ACID BY BRAIN TISSUE*

1958 • 157 citations

The action of β-phenyl-GABA derivatives on neurones of the cat cerebral cortex

1974 • 147 citations

Cellular localization of labeled gamma-aminobutyric acid (3H_GABA) in rat cerebellar cortex: an autoradiographic study

1970 • 145 citations

THE EXCITATION AND DEPRESSION OF MAMMALIAN CORTICAL NEURONES BY AMINO ACIDS

1964 • 143 citations

gamma-Aminobutyric acid (Gaba) and the dopamine hypothesis of schizophrenia

1977 • 141 citations

Catalytic inhibition of γ-aminobutyric acid-α-ketoglutarate transaminase of bacterial origin by 4-aminohex-5-ynoic acid, a substrate analog

1975 • 136 citations

KINETICS OF THE SODIUM‐DEPENDENT TRANSPORT OF GAMMA‐AMINOBUTYRIC ACID BY SYNAPTOSOMES

1973 • 133 citations

Molecular and Quantum Pharmacology

1974 • 128 citations

Stereospecificity of interaction of neuroleptic drugs with neurotransmitters and correlation with clinical potency

1976 • 124 citations

Amino acids as chemical transmitters

1980 • 120 citations

Environmental Effects on Molecular Structure and Properties

1976 • 116 citations

Amino Acids as Central Neurotransmitters

1975 • 112 citations

The inhibitory effect of sodium n‐dipropyl acetate on the degradative enzymes of the GABA shunt

1975 • 112 citations

Involvement of central GABA receptors in the regulation of blood pressure and heart rate of anesthetized cats

1977 • 108 citations

REVERSAL OF THE ACTION OF AMINO ACID ANTAGONISTS BY BARBITURATES AND OTHER HYPNOTIC DRUGS

1978 • 105 citations

COMPETITIVE INHIBITION OF GABA UPTAKE IN RAT BRAIN SLICES BY SOME GABA ANALOGUES OF RESTRICTED CONFORMATION

1972 • 105 citations

Stimulus-Coupled Secretion of γ-Aminobutyric Acid from Rat Brain Synaptosomes

1973 • 103 citations

Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system

1977 • 103 citations

Neurotransmitter receptor binding: regional distribution in human brain

1977 • 102 citations

Neurobiology and pharmacology of Huntington's disease

1977 • 96 citations

Baclofen: effects on amino acid release

1978 • 89 citations

Na+-independent binding of GABA to the triton X-100 treated synaptic membranes from cerebellum of rat brain

1977 • 78 citations

Biochemical Effects of Baclofen (β‐Parachlorophenyl‐GABA) on the Dopamine and the Noradrenaline in the Rat Brain

1977 • 76 citations

THE EFFECT ON GABA METABOLISM IN BRAIN OF ISONICOTINIC ACID HYDRAZIDE AND PYRIDOXINE AS A FUNCTION OF TIME AFTER ADMINISTRATION

1972 • 75 citations

THE ANTICONVULSANT ACTION OF GABA‐ELEVATING AGENTS: A RE‐EVALUATION

1975 • 73 citations

Microelectrophoretic studies on the depressant action of HA-966 on chemically and synaptically excited neurones in the cat cerebral cortex and cuneate nucleus

1973 • 73 citations

THE SUBCELLULAR DISTRIBUTION OF ENDOGENOUS AND EXOGENOUS SEROTONIN IN BRAIN TISSUE: COMPARISON OF SYNAPTOSOMES STORING SEROTONIN, NOREPINEPHRINE, AND γ‐AMINOBUTYRIC ACID¹

1971 • 71 citations

Antiseizure activity of gamma-acetylenic gamma-aminobutyric acid: a catalytic irreversible inhibitor of gamma-aminobutyric acid transaminase.

1977 • 68 citations

A new pyrrolizidine aminoalcohol in alkaloids from crotalaria species

1966 • 67 citations

GABA DERIVATIVE IN SPASTICITY (β-(4-Chlorophenyl)-γ-Aminobutyric Acid, Ciba 34.647-Bα)

1970 • 67 citations

The effects of l-2,4-diaminobutyric acid on the uptake of gamma-aminobutyric acid by a synaptosomal fraction from rat brain

1973 • 62 citations

The effect of phospholipases and proteases on the binding of γ-aminobutyric acid to junctional complexes of rat cerebellum

1976 • 62 citations

Separation of synaptosomes storing catecholamines and gamma-aminobutyric acid in rat corpus striatum

1970 • 60 citations

Development of rat brain uptake and calcium-dependent release of GABA

1978 • 60 citations

Gabaculine: γ-aminobutyrate aminotransferase inhibitor of microbial origin

1976 • 55 citations

SUBUNIT STRUCTURE AND KINETIC PROPERTIES OF 4‐AMINOBUTYRATE‐2‐KETOGLUTARATE TRANSAMINASE PURIFIED FROM MOUSE BRAIN

1974 • 55 citations

CALCIUM‐INDUCED RELEASE OF γ‐AMINOBUTYRIC ACID FROM SYNAPTOSOMES: EFFECTS OF TRANQUILIZER DRUGS

1977 • 55 citations

Transamination of analogues of γ-aminobutyric acid by extracts of rat brain mitochondria

1973 • 54 citations

Effects of β-(P-chlorophenyl)-GABA (BACLOFEN) on spinal synaptic activity

1977 • 49 citations

Effects of benzodiazepines and pentobarbitone on the GABA-ergic recurrent inhibition of hippocampal neurons

1978 • 48 citations

EFFECTS OF CHRONIC TREATMENT WITH AMINO‐OXYACETIC ACID OR SODIUM n‐DIPROPYLACETATE ON BRAIN GABA LEVELS AND THE DEVELOPMENT AND REGRESSION OF COBALT EPILEPTIC FOCI IN RATS

1976 • 47 citations

Inhibition by Neuroleptics of Uptake of ³H‐GABA into Rat Brain Synaptosomes

1978 • 47 citations

Inhibition of Cortical Neurones by Imidazole and Some Derivatives

1973 • 45 citations

Effects of calcium on the potassium-stimulated release of radioactive β-alanine and γ-aminobutyric acid from slices of rat cerebral cortex and spinal cord

1977 • 44 citations

GABA Receptor binding in frog spinal cord and brain

1977 • 41 citations

A COMPARISON OF γ‐AMINOBUTYRIC ACID AND THE SEMI‐RIGID ANALOGUES 4‐AMINOTETROLIC ACID, 4‐AMINOCROTONIC ACID AND IMIDAZOLE‐4‐ACETIC ACID ON THE ISOLATED SUPERIOR CERVICAL GANGLION OF THE RAT

1976 • 40 citations

Effect of ethanolamine-O-sulphate on regional gaba metabolism in the mouse brain

1977 • 37 citations

THE SELECTIVE NEURONAL UPTAKE AND RELEASE OF [³H]DL‐2,4‐DIAMINOBUTYRIC ACID BY RAT CEREBRAL CORTEX

1978 • 35 citations

Isolation and inhibitory activity of gabaculine, a new potent inhibitor of γ‐aminobutyrate aminotransferase produced by a Streptomyces

1977 • 33 citations

Neurotransmitter Function--Basic and Clinical Aspects

1978 • 33 citations

Induction of rotational behaviour by intranigral baclofen suggests possible GABA-agonist activity

1977 • 32 citations

Progress in Neurobiology: I. Neurochemistry

1956 • 28 citations

Organocobalt cluster complexes. 20. Novel chemistry of acyl- and aroylmethylidynetricobalt nonacarbonyl complexes. Unusual thermal ketone decarbonylation reactions

1976 • 16 citations

Synthesis of Some 4-Aminoalkyl-5-methyl-3-isoxazolols Structurally Related to Muscimol and gamma-Aminobutyric Acid (GABA).

1976 • 15 citations

Organic Hydroxylamine Derivatives. XII. Structural Analogues of gamma-Aminobutyric Acid (GABA) of the Isoxazole Enol-betaine Type. Synthesis of Some 3-Hydroxy-5-(1-aminoalkyl)isoxazole Zwitterions.

1974 • 14 citations

Nipecotic acid and 2,4-diaminobutyric acid enhance the actions of muscimol on cerebral cortical neurons

1978 • 13 citations

Muscimol Analogues. I. Syntheses of 4- and 8-Aminocyclohepteno[1,2-d]isoxazol-3-ols and 4-(3-Aminopropyl)-5-methyl-3-isoxazolol.

1977 • 10 citations

Effects of 2-propyl 2-pentenoic acid on the acquisition of conditioned behavior with negative reinforcement in mice

1976 • 4 citations

3-Isoxazolidone—An inhibitor of GABA metabolism

1976 • 3 citations