Homozygous deletions inactivateDCC, but notMADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

1994 • 1,142 citations

Mutations in the SMAD4/DPC4 Gene in Juvenile Polyposis

1998 • 901 citations

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene

1997 • 764 citations

DPC4 gene in various tumor types.

1996 • 680 citations

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1996 • 614 citations

Human Cancer Syndromes: Clues to the Origin and Nature of Cancer

1997 • 612 citations

The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis

1998 • 415 citations

Mad-related genes in the human

1996 • 308 citations

Allelotype of pancreatic adenocarcinoma using xenograft enrichment.

1995 • 308 citations

Homozygous deletion map at 18q21.1 in pancreatic cancer.

1996 • 269 citations

Somatic alterations of the DPC4 gene in human colorectal cancers in vivo

1996 • 259 citations

The DCC Gene: Structural Analysis and Mutations in Colorectal Carcinomas

1994 • 224 citations

Tumour-suppressor genes: evolving definitions in the genomic age

1997 • 148 citations

Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas.

1999 • 90 citations

The DCC gene suppresses the malignant phenotype of transformed human epithelial cells.

1995 • 88 citations

DCC: linking tumor suppressor genes and altered cell surface interactions in cancer?

1995 • 85 citations

Somatic alterations of the SMAD-2 gene in human colorectal cancers

1998 • 84 citations

Frequent allelic deletions and loss of expression characterize the DCC gene in male germ cell tumors.

1994 • 45 citations

Alterations in the deleted in colorectal carcinoma gene in human primary leukemia

1993 • 44 citations

Alterations in the deleted in colorectal carcinoma gene in human primary leukemia

1993 • 34 citations

Novel homozygous deletions of chromosomal band 18q22 in pancreatic adenocarcinoma identified by STS marker scanning

1999 • 11 citations