Structural features of neutral protease from Bacillus subtilis deduced from model‐building and limited proteolysis experiments

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrochemical Photolysis of Water at a Semiconductor Electrode

1972 • 30,988 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

A general method applicable to the search for similarities in the amino acid sequence of two proteins

1970 • 11,049 citations

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

Atlas of protein sequence and structure

1965 • 4,462 citations

Atlas of Protein Sequence and Structure, 1972.

1973 • 2,408 citations

A graphics model building and refinement system for macromolecules

1978 • 1,858 citations

Turns in Peptides and Proteins

1985 • 1,658 citations

Prediction of chain flexibility in proteins

1985 • 1,123 citations

Loops in Globular Proteins: A Novel Category of Secondary Structure

1986 • 533 citations

Structure of thermolysin refined at 1.6 Å resolution

1982 • 443 citations

The structure of thermolysin: An electron density map at 2.3 Å resolution

1972 • 315 citations

Correlation between sites of limited proteolysis and segmental mobility in thermolysin

1986 • 297 citations

Methods in Protein Sequence Analysis

1989 • 295 citations

Three-dimensional Structure of Thermolysin

1972 • 292 citations

Genes for alkaline protease and neutral protease from Bacillus amyloliquefaciens contain a large open reading frame between the regions coding for signal sequence and mature protein

1984 • 282 citations

The γ Turn, a Possible Folded Conformation of the Polypeptide Chain. Comparison with the β Turn

1972 • 271 citations

Activation of the Complement System by Antibody-Antigen Complexes: The Classical Pathway

1979 • 258 citations

Cloning of the neutral protease gene of Bacillus subtilis and the use of the cloned gene to create an in vitro-derived deletion mutation

1984 • 257 citations

Fluctuations in Protein Structure from X-Ray Diffraction

1984 • 254 citations

The Reverse Turn as a Polypeptide Conformation in Globular Proteins

1973 • 249 citations

Knowledge‐based protein modelling and design

1988 • 246 citations

Energy refinement of hen egg-white lysozyme

1974 • 233 citations

A new way of enhancing the thermostability of proteases

1986 • 226 citations

[87] Fluorescence measurements

1967 • 223 citations

Extension of the fragment method to calculate amino acid zwitterion and side chain partition coefficients

1987 • 221 citations

Metal Substitutions and Inhibition of Thermolysin: Spectra of the Cobalt Enzyme

1974 • 184 citations

Thermolysin: A zinc metalloenzyme

1969 • 175 citations

Evolution and the Tertiary Structure of Proteins

1984 • 173 citations

Role of calcium in thermolysin

1971 • 144 citations

Nucleotide sequence and promoter region for the neutral protease gene from Bacillus stearothermophilus

1985 • 136 citations

Crystal structure of neutral protease from Bacillus cereus refined at 3.0A˚resolution and comparison with the homologous but more thermostable enzyme thermolysin

1988 • 117 citations

Cloning and Nucleotide Sequence of the Highly Thermostable Neutral Protease Gene from Bacillus stearothermophilus

1988 • 82 citations

Amino acid sequence of thermolysin. Isolation and characterization of the fragments obtained by cleavage with cyanogen bromide

1972 • 75 citations

The Structural and Functional Roles of Metal Ions in Thermolysin

1978 • 71 citations

The Primary Structure ofBacillus cereusNeutral Proteinase and Comparison with Thermolysin andBacillus subtilisNeutral Proteinase

1986 • 64 citations

Effect of Glu-143 and His-231 substitutions on the catalytic activity and secretion of Bacillus subtilis neutral protease

1989 • 60 citations

Limited proteolysis of thermolysin by subtilisin: isolation and characterization of a partially active enzyme derivative

1985 • 51 citations

Thermitase, a thermostable subtilisin: Comparison of predicted and experimental structures and the molecular cause of thermostability

1989 • 51 citations

Folding of thermolysin fragments

1985 • 48 citations

Role of bound calcium ions in thermostable, proteolytic enzymes. II. Thermolysin, the thermostable protease from Bacillus thermoproteolyticus

1975 • 41 citations

[50] Thermolysin and other neutral metalloendopeptidases

1974 • 37 citations

nprR1 and nprR2 regulatory regions for neutral protease expression in Bacillus subtilis

1986 • 25 citations

The role of calcium in thermolysin: Effect on kinetic properties and autodigestion

1971 • 25 citations

Limited Proteolysis as a Tool to Detect Structure and Dynamic Features of Globular Proteins: Studies on Thermolysin

1989 • 16 citations

Structural alignment and analysis of two distantly related proteins:Aplysia limacina myoglobin and sea lamprey globin

1988 • 10 citations