Stimulus-excitation coupling in plasma membranes of pancreatic acinar cells

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

Physiology of the Gastrointestinal Tract.

1982 • 1,635 citations

The mechanism of pancreatic secretion

1902 • 1,209 citations

Relationships between calcium and cyclic nucleotides in cell activation.

1977 • 849 citations

Inward current channels activated by intracellular Ca in cultured cardiac cells

1981 • 687 citations

VARIATIONS IN TIGHT AND GAP JUNCTIONS IN MAMMALIAN TISSUES

1972 • 674 citations

Ca-dependent K channels with large unitary conductance in chromaffin cell membranes

1981 • 647 citations

Calcium transport in contraction and secretion

1975 • 567 citations

The stimulation of inositol lipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questions

1981 • 518 citations

CONDUCTANCE FLUCTUATIONS AND IONIC PORES IN MEMBRANES

1977 • 510 citations

Protein activator of cyclic 3′:5′-nucleotide phosphodiesterase of bovine or rat brain also activates its adenylate cyclase

1975 • 361 citations

The release of calcium from heart mitochondria by sodium

1974 • 353 citations

The Sodium‐Induced Efflux of Calcium from Heart Mitochondria

1976 • 350 citations

The gradient hypothesis and other models of carrier-mediated active transport

2005 • 327 citations

Evidence for Two Different Forms of Guanylate Cyclase in Rat Heart

1974 • 286 citations

Commentary on ‘Effects of acetylcholine on the turnover of phosphoryl units in individuals phospholipids of pancreas slices and brain cortex slices’ by L.E. Hokin and M.R. Hokin Biochim. Biophys. Acta 18 (1955) 102–110

1989 • 282 citations

SYNTHESIS, INTRACELLULAR TRANSPORT AND DISCHARGE OF EXPORTABLE PROTEINS IN THE PANCREATIC ACINAR CELL AND OTHER CELLS

1978 • 279 citations

Binding of cholecystokinin to high affinity receptors on isolated rat pancreatic acini.

1980 • 276 citations

Effects of acetylcholine on the turnover of phosphoryl units in individual phospholipids of pancreas slices and brain cortex slices

1955 • 253 citations

Calcium control of exocytosis and endocytosis in bovine adrenal medullary cells

1981 • 250 citations

Phosphoinositides and Protein Secretion in Pancreas Slices

1958 • 248 citations

Stimulus-permeability coupling: role of calcium in the receptor regulation of membrane permeability.

1978 • 239 citations

Neural regulation of pancreatic hormone secretion by the C-terminal tetrapeptide of CCK

1980 • 231 citations

The relationship between calcium exchange and enzyme secretion in the isolated rat pancreas

1973 • 229 citations

Subcellular Particles.

1960 • 221 citations

Ca++-dependent disassembly and reassembly of occluding junctions in guinea pig pancreatic acinar cells. Effect of drugs.

1978 • 197 citations

THE REGULATION OF INTRACELLULAR CALCIUM BY MITOCHONDRIA*

1978 • 191 citations

Gastrointestinal Hormones

1981 • 190 citations

Pancreatic acinar cells: acetylcholine‐induced membrane depolarization, calcium efflux and amylase release

1973 • 186 citations

Potassium conductance and internal calcium accumulation in a molluscan neurone

1980 • 170 citations

Action of cholecystokinin and cholinergic agents on calcium transport in isolated pancreatic acinar cells.

1975 • 163 citations

Actions of derivatives of cyclic nucleotides on dispersed acini from guinea pig pancreas. Discovery of a competitive antagonist of the action of cholecystokinin.

1979 • 158 citations

Pancreatic acinar cells: the role of calcium in stimulus‐secretion coupling.

1976 • 155 citations

Gap Junctional Communication

1981 • 152 citations

Electrophysiology of mammalian gland cells

1976 • 152 citations

Action of cholecystokinin, cholinergic agents, and A-23187 on accumulation of guanosine 3':5'-monophosphate in dispersed guinea pig pancreatic acinar cells.

1976 • 142 citations

Regulation of Pancreatic Exocrine Function In Vitro: Initial Steps in the Actions of Secretagogues

1979 • 141 citations

Hormonal Receptors in Digestive Tract Physiology

1977 • 138 citations

The Exocrine Pancreas: The Role of Secretagogues, Cyclic Nucleotides, and Calcium in Enzyme Secretion

1980 • 136 citations

The effect of methylxanthines and local anesthetics on fragmented sarcoplasmic reticulum.

1969 • 131 citations

DRIVING FORCES OF AMINO ACID TRANSPORT IN ANIMAL CELLS^fn1

1975 • 130 citations

The electrophysiology of gland cells

1980 • 126 citations

Isolation and amino acid sequences of alytesin and bombesin, two analogous active tetradecapeptides from the skin of European discoglossid frogs

1972 • 125 citations

EVIDENCE OF CHOLECYSTOKININ RELEASE BY BOMBESIN IN THE DOG

1974 • 124 citations

Calcium and pancreatic secretion. I. Subcellular distribution of calcium and magnesium in the exocrine pancreas of the guinea pig.

1975 • 123 citations

Dynamic changes of the luminal plasmalemma in stimulated parotid acinar cells. A freeze-fracture study.

1976 • 122 citations

Calcium ion uptake in isolated pancreas cells induced by secretagogues

1976 • 121 citations

In vitro action of bombesin and bombesin-like peptides on amylase secretion, calcium efflux, and adenylate cyclase activity in the rat pancreas: a comparison with other secretagogues.

1976 • 116 citations

The electrophysiology of gland cells

1981 • 114 citations

Adenylate cyclase in the rat pancreas properties and stimulation by hormones

1972 • 113 citations

Preparation of biologically active radioiodinated cholecystokinin for radioreceptor assay and radioimmunoassay.

1979 • 108 citations

Intracellular divalent cation release in pancreatic acinar cells during stimulus-secretion coupling. I. Use of chlorotetracycline as fluorescent probe.

1978 • 108 citations

Calcium uptake into acini from rat pancreas: Evidence for intracellular ATP-dependent calcium sequestration

1982 • 107 citations

The Bayliss‐Starling lecture 1973. The gastrointestinal hormones: a review of recent advances.

1974 • 103 citations

Innervation of the pancreas by vasoactive intestinal polypeptide (VIP) immunoreactive nerves

1978 • 100 citations

Pancreatic acinar cells: ionic dependence of acetylcholine‐induced membrane potential and resistance change.

1975 • 96 citations

Intracellular divalent cation release in pancreatic acinar cells during stimulus-secretion coupling. II. Subcellular localization of the fluorescent probe chlorotetracycline.

1978 • 83 citations

The functional integration of cells in animal tissues

1982 • 78 citations

Recognition Sites for Material Transport and Information Transfer

1975 • 76 citations

Effect of bombesin and related peptides on the release and action of intestinal hormones on pancreatic secretion.

1976 • 74 citations

Pancreatic acinar cells: localization of acetylcholine receptors and the importance of chloride and calcium for acetylcholine‐evoked depolarization

1977 • 70 citations

THE ROLE OF CALCIUM IN PANCREATIC ACINAR CELL STIMULUS‐SECRETION COUPLING: AN ELECTROPHYSIOLOGICAL APPROACH*

1978 • 70 citations

In vitro action of bombesin on amylase secretion, membrane potential, and membrane resistance in rat and mouse pancreatic acinar cells. A comparison with other secretagogues.

1978 • 68 citations

Pancreatic acinar cells: the acetylcholine equilibrium potential and its ionic dependency

1977 • 64 citations

The measurement of membrane potential using optical indicators

1981 • 62 citations

Pancreatic acinar cells: the effect of carbon dioxide, ammonium chloride and acetylcholine on intercellular communication

1979 • 60 citations

Cyclic nucleotide-dependent protein kinases of the rat pancreas

1973 • 60 citations

Pitfalls of the 45Ca uptake method

1981 • 58 citations

Stimulation of alanine transport and metabolism by dibutyryl cyclic AMP in the hepatocytes from fed rats Assessment of transport as a potential rate-limiting step for alanine metabolism

1981 • 57 citations

Intracellular messenger role of cyclic GMP in exocrine pancreas

1976 • 56 citations

Ca++ fluxes in isolated cells of rat pancreas. Effect of secretagogues and different Ca++ concentrations

1976 • 54 citations

Biology of normal and cancerous Exocrine Pancreatic Cells

1981 • 51 citations

Effects of the calcium ionophore A23187 on pancreatic acinar cell membrane potentials and amylase release.

1977 • 48 citations

Role of calcium in exocrine pancreatic secretion I. Calcium movements in the rabbit pancreas

1975 • 48 citations

Increased intracellular cyclic GMP does not correlate with protein discharge from pancreatic acinar cells

1979 • 44 citations

Stimulation of the glucose transport system in isolated mouse pancreatic acini by cholecystokinin and analogues.

1979 • 41 citations

CALCIUM AND PANCREATIC SECRETION‐DYNAMICS OF SUBCELLULAR CALCIUM POOLS IN RESTING AND STIMULATED ACINAR CELLS

1975 • 39 citations

Separate activation sites for cholecystokinin and bombesin on pancreatic acini

1979 • 38 citations

Cyclic nucleotide-dependent protein kinase activity in acinar cells from guinea pig pancreas

1978 • 37 citations

Ionic currents across pancreatic acinar cell membranes and their role in fluid secretion

1981 • 37 citations

A Calcium‐Dependent Protein Activator of Guanosine 3′:5′‐Monophosphate Phosphodiesterase in Bovine and Rat Pancreas

1977 • 37 citations

Amino acids evoke short-latency membrane conductance increase in pancreatic acinar cells

1980 • 37 citations

Mouse pancreatic acinar cells: the anion selectivity of the acetylcholine‐opened chloride pathway.

1980 • 35 citations

Equilibrium and steady-state models of the coupling between the amino acid gradient and the sodium electrochemical gradient in mouse ascites- tumour cells

1978 • 34 citations

"In vitro" effects of secretin and vasoactive intestinal polypeptide on hydrolase secretion and cylic AMP levels in the pancreas of five animal species. A comparison with caerulein.

1977 • 33 citations

Pancreatic acinar cells: effects of microionophoretic polypeptide application on membrane potential and resistance

1979 • 33 citations

Control of pancreatic cyclic nucleotide levels and amylase secretion by noncholinergic, nonadrenergic nerves. A study employing electrical field stimulation of guinea pig segments.

1981 • 33 citations

Studies on isolated subcellular components of cat pancreas

1978 • 32 citations

Pancreozymin and caerulein stimulate in vitro protein phosphorylation in the rat pancreas

1973 • 32 citations

Rat pancreas adenylate cyclase II. Inactivation and protection of its hormone receptor sites

1974 • 32 citations

Drug receptors and their effectors

1980 • 31 citations

Mouse pancreatic acinar cells: effects of electrical field stimulation on membrane potential and resistance.

1980 • 26 citations

Ca2+ control of electrolyte permeability in plasma membrane vesicles from cat pancreas

1979 • 26 citations

Control of enzyme secretion by non-cholinergic, non-adrenergic nerves in guinea pig pancreas

1981 • 25 citations

The role of calcium in parotid amylase secretion evoked by excitation of cholinergic, ?- and?-adrenergic receptors

1977 • 25 citations

Calcium transport in dispersed acinar cells from rat pancreas

1977 • 25 citations

Role of calcium in exocrine pancreatic secretion. IV. Calcium movements in isolated acinar cells of rabbit pancreas

1978 • 24 citations

Partial purification of adenosine 3′,5′-cyclic monophosphate phosphodiesterases from rat pancreas in the presence of excess protease inhibitors

1976 • 23 citations

Pancreatic acinar cells: electrophysiological evidence for stimulant‐evoked increase in membrane calcium permeability in the mouse.

1980 • 23 citations

Hydrolysis of the Cyclic 3′:5′‐Monophosphates of Adenosine and Guanosine by Rat Pancreas

1974 • 22 citations

Amino acid-evoked membrane potential and resistance changes in pancreatic acinar cells

1980 • 20 citations

Mouse pancreatic acinar cells: voltage‐clamp study of acetylcholine‐evoked membrane current.

1981 • 20 citations

Effect of carbachol on radiosodium uptake by dispersed pancreatic acinar cells

1980 • 19 citations

Effect of Neural Stimulation on Acinar Cell Membrane Potentials in Isolated Pancreas and Salivary Gland Segments

1980 • 18 citations

Acetylcholine-evoked uncoupling restricts the passage of Lucifer Yellow between pancreatic acinar cells

1982 • 18 citations

Effects of intracellular EGTA injection on stimulant-evoked membrane potential and resistance changes in pancreatic acinar cells

1980 • 17 citations

Analysis of Ca ²⁺ fluxes and Ca ²⁺ pools in pancreatic acini

1981 • 16 citations

Protein phosphorylation during secretion in the rat lacrimal gland

1981 • 16 citations

Two different types of electrogenic amino acid action on pancreatic acinar cells

1981 • 15 citations

Ionophore A23187 can mimick the changes in membrane permeability that occur during acetylcholine-stimulation of pancreatic acinar secretion

1982 • 14 citations

MECHANISMS OF ACTION OF HORMONAL AND NEURONAL PEPTIDES ON EXOCRINE GLAND CELLS

1982 • 13 citations

The relationship between stimulation-induced potassium release and amylase secretion in the mouse parotid

1977 • 12 citations

Multiple effects of Na+ removal on pancreatic secretion in vitro

1980 • 12 citations

Role of calcium in exocrine pancreas secretion VII. Effect of sodium on enzyme secretion and calcium metabolism in rabbit pancreatic fragments and acinar cells

1981 • 7 citations

Effect of acetylcholine stimulation on calcium and sodium uptake by the isolated rat pancreas.

1979 • 6 citations

Determining steps in the regulatory GTPase cycle of rat pancreatic adenylate cyclase

1981 • 5 citations

Role of calcium in stimulation of 36Cl uptake by dispersed pancreatic acinar cells

1980 • 5 citations

Effects of CO2, acetylcholine and caerulein on45Ca efflux from isolated mouse pancreatic fragments

1981 • 4 citations

Secretin, Cholecystokinin, Pancreozymin and Gastrin.

1974 • 2 citations

Concluding remarks

1981 • 1 citations