Apoptotic and Necrotic Death Mechanisms Are Concomitantly Activated in the Same Cell After Cerebral Ischemia

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Mechanisms, challenges and opportunities in stroke

2003 • 1,688 citations

Four deaths and a funeral: from caspases to alternative mechanisms

2001 • 1,605 citations

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1994 • 1,106 citations

Calpain and caspase: can you tell the difference?

2000 • 911 citations

Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia

1998 • 899 citations

Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

1997 • 835 citations

Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

1993 • 703 citations

Neurodegeneration in Excitotoxicity, Global Cerebral Ischemia, and Target Deprivation: A Perspective on the Contributions of Apoptosis and Necrosis

1998 • 702 citations

Temporal Profile of in situ DNA Fragmentation after Transient Middle Cerebral Artery Occlusion in the Rat

1995 • 477 citations

Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates

2000 • 347 citations

Apoptosis and Necrosis after Reversible Focal Ischemia: An in Situ DNA Fragmentation Analysis

1996 • 339 citations

Gene Expression Induced by Cerebral Ischemia: An Apoptotic Perspective

1997 • 305 citations

Neuronal cell death: a demise with different shapes

1999 • 258 citations

BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia

2001 • 252 citations

Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease.

1998 • 248 citations

An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat

1996 • 207 citations

Role of Endothelial Nitric Oxide Generation and Peroxynitrite Formation in Reperfusion Injury After Focal Cerebral Ischemia

2000 • 191 citations

Neuroprotective effects of gelsolin during murine stroke

1999 • 156 citations

Mechanisms of Hypoxic Neurodegeneration in the Developing Brain

2002 • 132 citations

Energy Requirement for Caspase Activation and Neuronal Cell Death

2000 • 130 citations

Immunohistochemical and biochemical assessment of caspase-3 activation and DNA fragmentation following transient focal ischemia in the rat

2002 • 125 citations

Neuronal apoptosis in acute necrotic insults: why is this subject such a mess?

1999 • 115 citations

Ultrastructural morphological changes are not characteristic of apoptotic cell death following focal cerebral ischaemia in the rat

1996 • 105 citations

Assay of caspase activation in situ combined with probing plasma membrane integrity to detect three distinct stages of apoptosis

2002 • 83 citations

Cathepsin B and middle cerebral artery occlusion in the rat

1997 • 67 citations

A lysosomal protease enters the death scene

2001 • 66 citations

Cerebral Ischemia Produces Laddered DNA Fragments Distinct from Cardiac Ischemia and Archetypal Apoptosis

1999 • 52 citations

Nitric oxide is involved in ischemia-induced apoptosis in brain: a study in neuronal nitric oxide synthase null mice

2001 • 49 citations

Chronic daily administration of selegiline and EGb 761 increases brain’s resistance to ischemia in mice

2001 • 37 citations

Free fatty acids, lipid peroxidation, and lysosomal enzymes in experimental focal cerebral ischemia in primates: Loss of lysosomal latency by lipid peroxidation

1988 • 17 citations