NMR studies of novel inhibitors bound to farnesyl‐protein transferase

Macromodel—an integrated software system for modeling organic and bioorganic molecules using molecular mechanics

1990 • 3,683 citations

MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy

1985 • 3,603 citations

Coherence transfer by isotropic mixing: Application to proton correlation spectroscopy

1983 • 2,638 citations

A two-dimensional nuclear overhauser experiment with pure absorption phase in four quadrants

1982 • 2,567 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

Structure determination of a tetrasaccharide: transient nuclear Overhauser effects in the rotating frame

1984 • 1,650 citations

FUNCTION AND REGULATION OF RAS

1993 • 1,161 citations

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

1990 • 815 citations

Benzodiazepine Peptidomimetics: Potent Inhibitors of Ras Farnesylation In Animal Cells

1993 • 631 citations

Sequence dependence of protein isoprenylation

1991 • 580 citations

Selective Inhibition of ras -Dependent Transformation by a Farnesyltransferase Inhibitor

1993 • 578 citations

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

1994 • 523 citations

Ras C-terminal processing enzymes—New drug targets?

1991 • 461 citations

Theory and applications of the transferred nuclear overhauser effect to the study of the conformations of small ligands bound to proteins

1982 • 392 citations

Broadband heteronuclear decoupling

1982 • 388 citations

PROTEIN PRENYLATION: GENES, ENZYMES, TARGETS, AND FUNCTIONS

1992 • 380 citations

Frequency offset effects and their elimination in NMR rotating-frame cross-relaxation spectroscopy

1987 • 367 citations

Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase.

1991 • 312 citations

Bioactive Conformation of Luteinizing Hormone-Releasing Hormone: Evidence from a Conformationally Constrained Analog

1980 • 311 citations

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice.

1994 • 287 citations

Theory of the time dependent transferred nuclear Overhauser effect: Applications to structural analysis of ligand-protein complexes in solution

1983 • 285 citations

Different conformations for the same polypeptide bound to chaperones DnaK and GroEL

1992 • 285 citations

Peptidomimetic inhibitors of Ras farnesylation and function in whole cells.

1993 • 222 citations

Protein prenylation: more than just glue?

1992 • 208 citations

Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase

1991 • 183 citations

Characterization of recombinant human farnesyl-protein transferase: Cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases

1993 • 136 citations

Conformational constraints: Nonpeptide β‐turn mimics

1990 • 127 citations

Design and structural requirements of potent peptidomimetic inhibitors of p21ras farnesyltransferase.

1994 • 116 citations

Potent inhibition of human tumor p21ras farnesyltransferase by A1A2-lacking p21ras CA1A2X peptidomimetics.

1993 • 112 citations

Pseudopeptide Inhibitors of Ras Farnesyl-Protein Transferase

1994 • 109 citations

Cloning and expression of a cDNA encoding the alpha subunit of rat p21ras protein farnesyltransferase.

1991 • 88 citations

Stereochemistry of binding of the tetrapeptide acetyl-Pro-Ala-Pro-Tyr-NH2 to porcine pancreatic elastase

1986 • 85 citations

Posttranslational processing of the ras superfamily of small GTP-binding proteins

1993 • 83 citations

Conformation of a heptapeptide substrate bound to protein farnesyltransferase

1993 • 55 citations

Two-dimensional transferred nuclear Overhauser effect spectroscopy (TRNOESY) studies of nucleotide conformations in creatine kinase complexes: Effects due to weak nonspecific binding

1993 • 52 citations

Solution structure of a platelet receptor peptide bound to bovine .alpha.-thrombin

1992 • 47 citations

Accounting for Ligand-Protein Interactions in the Relaxation-Matrix Analysis of Transferred Nuclear Overhauser Effects

1994 • 41 citations

Interaction of troponin I and troponin C: use of the two-dimensional transferred nuclear Overhauser effect to determine the structure of a Gly-110 inhibitory troponin I peptide analog when bound to cardiac troponin C

1992 • 29 citations

Micelle-bound conformations of a bombesin/gastrin releasing peptide receptor agonist and an antagonist by two-dimensional NMR and restrained molecular dynamics

1992 • 25 citations

Studies of Inhibitor Binding to Escherichia coli Purine Nucleoside Phosphorylase Using the Transferred Nuclear Overhauser Effect and Rotating-Frame Nuclear Overhauser Enhancement

1994 • 21 citations

Two-Dimensional Transferred Nuclear Overhauser Effect Spectroscopy Study of the Conformation of MgATP Bound at the Active and Ancillary Sites of Rabbit Muscle Pyruvate Kinase

1994 • 20 citations

Nuclear Overhauser effect studies on the conformations of Mg(alpha, beta-methylene)ATP bound to Escherichia coli methionyl-tRNA synthetase

1991 • 15 citations

Conformation of ATP and ADP Bound to N10-Formyltetrahydrofolate Synthetase Determined by TRNOE NMR Spectroscopy

1994 • 10 citations

Synthesis of New Peptides Based on Models of Receptor-Bound Conformation

1987 • 9 citations

Conformation of dCDP Bound to Protein R1 of Escherichia coli Ribonucleotide Reductase

1994 • 4 citations