Reduction of chronic doxorubicin cardiotoxicity in beagle dogs by bis-morpholinomethyl derivative of razoxane (ICRF-159)

Anthracycline cardiomyopathy monitored by morphologic changes.

1978 • 589 citations

Clinical spectrum of anthracycline antibiotic cardiotoxicity.

1978 • 249 citations

Oxidative destruction of erythrocyte ghost membranes catalyzed by the doxorubicin-iron complex

1982 • 238 citations

Adriamycin-induced cardiotoxicity (cardiomyopathy and congestive heart failure) in rats.

1977 • 166 citations

Antitumour Activity in a Series of bisDiketopiperazines

1969 • 159 citations

Comparison of the effectiveness of (+/-)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane (ICRF-187) and N-acetylcysteine in preventing chronic doxorubicin cardiotoxicity in beagles.

1985 • 119 citations

Reduction of chronic doxorubicin cardiotoxicity in dogs by pretreatment with (+/-)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane (ICRF-187).

1981 • 107 citations

Influence of vitamin E and ICRF-187 on chronic doxorubicin cardiotoxicity in miniature swine.

1983 • 80 citations

Doxorubicin Hydrochloride-Associated Renal Failure

1977 • 77 citations

Biological Properties of ICRF-159 and Related Bis(dioxopiperazine) Compounds

1982 • 65 citations

Reduction of chronic daunorubicin cardiotoxicity by ICRF-187 in rabbits.

1981 • 59 citations

Utilization of an enantiomer as a solution to a pharmaceutical problem: Application to solubilization of 1,2‐di(4‐piperazine‐2,6‐dione)propane

1976 • 56 citations

Studies on the stability and cellular distribution of dioxopiperazines in cultured BHK-21S cells

1975 • 54 citations

Preliminary Clinical Assessment of I.C.R.F. 159 in Acute Leukaemia and Lymphosarcoma

1969 • 53 citations

Reduction of daunorubicin lethality and myocardial cellular alterations by pretreatment with ICRF-187 in Syrian golden hamsters.

1979 • 52 citations

Modification of some of the toxic effects of daunomycin (NSC-82,151) by pretreatment with the antineoplastic agent ICRF 159 (NSC-129,943)

1974 • 48 citations

Stereoselective effects of cis- and trans-cyclopropylbis(dioxopiperazines) related to ICRF-159 on metastases of a hamster lung adenocarcinoma

1978 • 21 citations

Comparison of the Protective Effect of ICRF-187 and Structurally Related Analogues Against Acute Daunorubicin Toxicity in Syrian Golden Hamsters

1985 • 18 citations

Synthesis and antimetastatic properties of stereoisomeric tricyclic bis(dioxopiperazines) in the Lewis lung carcinoma model

1985 • 14 citations

Bimolane: Structure Determination Indicates Anticancer Activity Is Attributable to ICRF-154

1984 • 9 citations

Stereoselective antitumor properties in the Lewis Lung carcinoma model using bis(morpholinomethyl) derivatives of tricyclic bis(dioxopiperazines)

1985 • 4 citations

Preliminary Data on Acute Leukemia Treatment with ICRF 159

1970 • 3 citations