Biological Properties of ICRF-159 and Related Bis(dioxopiperazine) Compounds

A clinicopathologic analysis of adriamycin cardiotoxicity

1973 • 1,534 citations

Adriamycin: The Role of Lipid Peroxidation in Cardiac Toxicity and Tumor Response

1977 • 1,116 citations

Adjuvant Therapy of Cancer

1990 • 534 citations

Daunomycin, an antitumor antibiotic, in the treatment of neoplastic disease.Clinical evaluation with special reference to childhood leukemia

1967 • 470 citations

Organ Selectivity for Implantation Survival and Growth of B16 Melanoma Variant Tumor Lines 2

1976 • 297 citations

Oxidative destruction of erythrocyte ghost membranes catalyzed by the doxorubicin-iron complex

1982 • 238 citations

Antineoplastic and Immunosuppressive Agents

1975 • 236 citations

Metal Binding in Medicine

1961 • 210 citations

THE EFFECT OF IRON ON THE DISTRIBUTION OF SUPEROXIDE AND HYDROXYL RADICALS AS SEEN BY SPIN TRAPPING AND ON THE SUPEROXIDE DISMUTASE ASSAY

1978 • 179 citations

Inhibition of Alloxan Action in Isolated Pancreatic Islets by Superoxide Dismutase, Catalase, and a Metal Chelator

1980 • 159 citations

Antitumour Activity in a Series of bisDiketopiperazines

1969 • 159 citations

NEPHROTOXIC HAZARD FROM UNCONTROLLED EDATHAMIL CALCIUM-DISODIUM THERAPY

1956 • 149 citations

Metastases and the Normalization of Tumour Blood Vessels by ICRF 159: A New Type of Drug Action

1972 • 136 citations

Chemotherapy of cancer dissemination and metastasis

1973 • 136 citations

Pathologic Changes Associated with the Use of Sodium Ethylene Diamine Tetra-Acetate in the Treatment of Hypercalcemia

1955 • 110 citations

Reduction of chronic doxorubicin cardiotoxicity in dogs by pretreatment with (+/-)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane (ICRF-187).

1981 • 107 citations

Control of Malignant Metastases by ICRF 159

1969 • 105 citations

Inhibition of Metastatic Spread by I.C.R.F. 159: Selective Deletion of a Malignant Characteristic

1970 • 90 citations

Mode of Action of the Cytostatic Agent ‘ICRF 159’

1970 • 90 citations

An experimental model for studying factors which influence metastasis of malignant tumors

1967 • 72 citations

Histological analysis of the antimetastatic effect of (plus or minus)-1,2-bis(3,5-dioxopiperazin-1-yl)propane.

1974 • 68 citations

The effects of α-tocopherol on the toxicity, disposition, and metabolism of adriamycin in mice

1979 • 66 citations

Techniques for inhibiting tumor metastases

1975 • 64 citations

Inhibition of alloxan action in isolated pancreatic islets by superoxide dismutase, catalase, and a metal chelator

1980 • 64 citations

Prevention of the Cardiotoxic Effects of Adriamycin and Daunomycin in the Isolated Dog Heart

1972 • 61 citations

An evaluation of the nephrotoxicity of ethylenediaminetetraacetate and diethylenetriaminepentaacetate in the rat

1967 • 59 citations

ICRF 159, (±) 1,2-di(3,5-dioxopiperazin-1-yl)propane NSC-129,943; Razoxane

1976 • 56 citations

Utilization of an enantiomer as a solution to a pharmaceutical problem: Application to solubilization of 1,2‐di(4‐piperazine‐2,6‐dione)propane

1976 • 56 citations

Razoxane (ICRF 159) in the treatment of psoriasis

1980 • 55 citations

Studies on the stability and cellular distribution of dioxopiperazines in cultured BHK-21S cells

1975 • 54 citations

Preliminary Clinical Assessment of I.C.R.F. 159 in Acute Leukaemia and Lymphosarcoma

1969 • 53 citations

Effect of (plus or minus)-1,2-bis(3,5-dioxopiperazin-1-yl)propane on tumor blood vessels and its relationship to the antimetastatic effect in the Lewis lung carcinoma.

1974 • 49 citations

Synergism of ICRF 159 and radiotherapy in treatment of experimental tumors

1974 • 48 citations

Modification of some of the toxic effects of daunomycin (NSC-82,151) by pretreatment with the antineoplastic agent ICRF 159 (NSC-129,943)

1974 • 48 citations

A study of the influence of various diagnostic and therapeutic procedures applied to a murine squamous carcinoma on its metastatic behaviour

1975 • 39 citations

Combined treatment of soft tissue and osteosarcomas by radiation and ICRF 159

1974 • 37 citations

Effect of ICRF 159 on the Mammalian Cell Cycle: Significance for Its Use in Cancer Chemotherapy

1970 • 33 citations

Experimental acetaminophen-induced hepatic necrosis: biochemical and electron microscopic study of cysteamine protection.

1978 • 32 citations

Reduction of daunomycin toxicity by razoxane

1981 • 32 citations

Cumulative Cytostatic Effect of ICRF 159

1974 • 32 citations

Biochemical studies on growth‐inhibitory bisdioxopiperazines. I. Effect on dna, rna and protein synthesis in mouse‐embryo fibroblasts

1970 • 31 citations

Comparative study of early effects of epipodophyllotoxin derivatives and other cytostatic agents on mastocytoma cultures.

1977 • 30 citations

Modification of the radiocurability of a syngeneic murine squamous carcinoma by its site of growth, by electron-affinic drugs, and by ICRF 159

1976 • 27 citations

Study of trans-cyclopropylbis(diketopiperazine) and chelating agents related to ICRF 159. Cytotoxicity, mutagenicity, and effects on scheduled and unscheduled DNA synthesis

1977 • 25 citations

Selective antimetastatic treatment—current status and future prospects

1974 • 23 citations

Stereoselective effects of cis- and trans-cyclopropylbis(dioxopiperazines) related to ICRF-159 on metastases of a hamster lung adenocarcinoma

1978 • 21 citations

Double blind controlled clinical trial of radiation plus razoxane (ICRF 159) versus radiation plus placebo in the treatment of head and neck cancer

1978 • 19 citations

ICRF-159: Current status and clinical prospects

1977 • 18 citations

Radiotherapy combined with ICRF 159 (NSC 129943)

1978 • 18 citations

Determination of (±)‐1,2‐Bis(3,5‐dioxopiperazinyl) propane Plasma Levels in Rats, Rabbits, and Humans by GLC and Mass Fragmentography

1975 • 16 citations

Interaction of ICRF 159 with radiation, and its effect on sub-lethal and potentially lethal radiation damage in vitro

1977 • 16 citations

The effect of bisdioxopiperazines on the synthesis of deoxyribonucleic acid, ribonucleic acid and protein in growing mouse-embryo fibroblasts

1969 • 15 citations

Proceedings: Mechanism of action studies with IRCF 159: effects on the growth and morphology of BHK-21S cells

1974 • 13 citations

The effect of (±) 1,2-bis(3,5-dioxopiperazin-1-yl) propane (ICRF 159) on liver metastases from a hamster lymphoma

1975 • 13 citations

Enhancement of experimental lung metastases by cultured B16 melanoma cells treated with (+/-)-1,2-bis(3,5-dioxopiperazin-1-y)propane (ICRF-159).

1978 • 12 citations

Clinical trial of razoxane and radiotherapy for inoperable carcinoma of the bronchus

1979 • 11 citations

Interference with in vivo growth and metastasis of prostate adenocarcinoma (PA‐III) by ICRF‐159

1981 • 11 citations

Proceedings: Analysis of the antimetastatic action of the antimitotic agent ICRF 159

1974 • 10 citations

Further Experience with Rezoxane (ICRF 159; – NSC – 129943) in Treating Kaposi’s Sarcoma

1980 • 9 citations

Synthesis and antimetastatic properties of stereoisomeric tricyclic bis(dioxopiperazine) analogs in a B16 melanoma model

1981 • 8 citations

Influence of ICRF 159 and triton WR 1339 on metastases of a rat epithelioma

1975 • 8 citations

A clinical evaluation of ICRF 159 as a radiosensitising agent

1978 • 7 citations

Screening data from the Cancer Chemotherapy National Service Center Screening Laboratories. II.

1959 • 6 citations

Effect of stereoisomers related to ICRF-159 on metastasis of B16 melanoma

1981 • 6 citations

Combination of radiation and razoxane (ICRF 159) in vivo

1978 • 5 citations

A comprehensive model for interstitial implant dosimetry

1979 • 4 citations

Effect of Razoxane (ICRF 159) on Daunomycin (NSC 82151) Metabolism and DNA Complexation

1980 • 3 citations

Radiotherapy and ICRF 159 in the treatment of soft tissue sarcomas

1978 • 3 citations