IL-18 enhances SCF production of melanoma cells by regulating ROI and p38 MAPK activity

Cloning of a new cytokine that induces IFN-γ production by T cells

1995 • 2,584 citations

The p38 signal transduction pathway Activation and function

2000 • 1,560 citations

Stem Cell Factor and Hematopoiesis

1997 • 850 citations

Early signaling pathways activated by c-Kit in hematopoietic cells

1999 • 385 citations

Interleukin-18 (Interferon-γ–inducing Factor) Is Produced by Osteoblasts and Acts Via Granulocyte/Macrophage Colony-stimulating Factor and Not Via Interferon-γ to Inhibit Osteoclast Formation

1997 • 381 citations

IL-18 regulates IL-1β-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1

2000 • 335 citations

Selective growth of human mast cells induced by Steel factor, IL-6, and prostaglandin E2 from cord blood mononuclear cells.

1996 • 324 citations

Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2.

1992 • 320 citations

Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor.

1992 • 306 citations

Effect of IL-3 and stem cell factor on the appearance of human basophils and mast cells from CD34+ pluripotent progenitor cells.

1992 • 289 citations

Stem cell factor is a chemotactic factor for human mast cells.

1994 • 282 citations

Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases

2000 • 280 citations

Recombinant human stem cell factor (kit ligand) promotes human mast cell and melanocyte hyperplasia and functional activation in vivo.

1996 • 273 citations

Production of IL-18 (IFN-gamma-inducing factor) messenger RNA and functional protein by murine keratinocytes.

1997 • 267 citations

Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase.

1991 • 265 citations

Altered Metabolism of Mast-Cell Growth Factor (c-kit Ligand) in Cutaneous Mastocytosis

1993 • 261 citations

Superoxide anion is a natural inhibitor of FAS-mediated cell death.

1996 • 241 citations

Interleukin-12 (IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans through production of gamma interferon by natural killer cells

1997 • 229 citations

Murine Cutaneous Mastocytosis and Epidermal Melanocytosis Induced by Keratinocyte Expression of Transgenic Stem Cell Factor

1998 • 200 citations

Reactive Oxygen Intermediates Are Involved in the Induction of CD95 Ligand mRNA Expression by Cytostatic Drugs in Hepatoma Cells

1997 • 180 citations

Hemopoietic Growth Factors with the Exception of Interleukin-4 Activate the p38 Mitogen-activated Protein Kinase Pathway

1997 • 172 citations

Reactive oxygen intermediates as regulators of TNF-alpha production in rat lung inflammation induced by silica.

1996 • 162 citations

Nonhematopoietic tumor cell lines express stem cell factor and display c-kit receptors

1992 • 160 citations

Coexpression of the c-kit and stem cell factor genes in breast carcinomas.

1995 • 151 citations

Constitutive expression of steel factor gene by human stromal cells

1993 • 148 citations

Activation of Mitogen-Activated Protein Kinase Regulates Eotaxin-Induced Eosinophil Migration

1999 • 142 citations

Elevated secretion of reactive nitrogen and oxygen intermediates by inflammatory leukocytes in hyperacute experimental autoimmune encephalomyelitis: enhancement by the soluble products of encephalitogenic T cells.

1992 • 136 citations

Nonhematopoietic tumor cell lines express stem cell factor and display c-kit receptors

1992 • 131 citations

Structure of the active core of human stem cell factor and analysis of binding to its receptor Kit

2000 • 115 citations

Fas Ligand Induction in Human NK Cells Is Regulated by Redox Through a Calcineurin-Nuclear Factors of Activated T Cell-Dependent Pathway

1999 • 95 citations

Endogenous interleukin-18 modulates immune escape of murine melanoma cells by regulating the expression of Fas ligand and reactive oxygen intermediates.

2000 • 81 citations

Molecular mechanisms of melanoma metastasis

1997 • 78 citations

Enhanced IL-18 expression in common skin tumors

2001 • 78 citations

Growth stimulation of colorectal carcinoma cells via the c-kit receptor is inhibited by TGF-β1

1997 • 70 citations

Expression of stem cell factor in cutaneous mastocytosis

1995 • 62 citations

Stem cell factor augments Fc epsilon RI-mediated TNF-alpha production and stimulates MAP kinases via a different pathway in MC/9 mast cells.

1998 • 56 citations

Human Dermal Endothelial Cells Express Membrane-Associated Mast Cell Growth Factor

1995 • 54 citations

Antitumor Effects on Mouse Melanoma Elicited by Local Secretion of Interleukin-12 and Their Enhancement by Treatment with Interleukin-18

2000 • 54 citations

Expression of stem cell factor and its receptor by human neuroblastoma cells and tumors

1995 • 51 citations

Stem Cell Factor Regulates Human Melanocyte‐Matrix Interactions

1994 • 47 citations

Stem Cell Factor Augments FcεRI-Mediated TNF-α Production and Stimulates MAP Kinases via a Different Pathway in MC/9 Mast Cells

1998 • 46 citations

Regulation of the Melanoma Cell Adhesion Molecule Gene in Melanoma: Modulation of mRNA Synthesis by Cyclic Adenosine Monophosphate, Phorbol Ester, and Stem Cell Factor/c-Kit Signaling

1999 • 13 citations

Tumor progression in melanoma: the biology of epidermal melanocytes in vitro.

1989 • 13 citations