Notch1IC Partially Replaces EBNA2 Function in B Cells Immortalized by Epstein-Barr Virus

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

Epstein-Barr Virus

1986 • 2,255 citations

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Epstein-Barr virus and its replication

1996 • 1,621 citations

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1998 • 1,600 citations

Signalling downstream of activated mammalian Notch

1995 • 1,375 citations

Presenilin is required for activity and nuclear access of Notch in Drosophila

1999 • 801 citations

Nuclear Access and Action of Notch In Vivo

1998 • 730 citations

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.

1996 • 717 citations

Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

2000 • 641 citations

Genetic analysis of immortalizing functions of Epstein–Barr virus in human B lymphocytes

1989 • 553 citations

LIN-12/Notch signaling: lessons from worms and flies

1998 • 545 citations

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants

1999 • 494 citations

Epstein-Barr virus nuclear protein 2 is a key determinant of lymphocyte transformation.

1989 • 491 citations

The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD

1994 • 483 citations

Intrinsic activity of the lin-12 and Notch intracellular domains in vivo

1993 • 466 citations

Mediation of Epstein-Barr Virus EBNA2 Transactivation by Recombination Signal-Binding Protein J _κ

1994 • 462 citations

Truncated Mammalian Notch1 Activates CBF1/RBPJk-Repressed Genes by a Mechanism Resembling That of Epstein-Barr Virus EBNA2

1996 • 459 citations

Diverse Signaling Pathways Activated by Growth Factor Receptors Induce Broadly Overlapping, Rather Than Independent, Sets of Genes

1999 • 450 citations

The Notch Ligand Jagged-1 Represents a Novel Growth Factor of Human Hematopoietic Stem Cells

2000 • 432 citations

Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.

1993 • 421 citations

Epstein-Barr virus nuclear antigen 2 specifically induces expression of the B-cell activation antigen CD23.

1987 • 397 citations

Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway

1996 • 372 citations

The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the J kappa recombination signal binding protein.

1994 • 352 citations

Notch2: a second mammalian Notch gene

1992 • 346 citations

A homolog of Drosophila Notch expressed during mammalian development

1991 • 338 citations

The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium

1994 • 318 citations

An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye

1993 • 307 citations

Early events in Epstein-Barr virus infection of human B lymphocytes

1991 • 297 citations

Recognition sequence of a highly conserved DNA binding protein RBP-J_x

1994 • 287 citations

The Proto-Oncogene c- myc Is a Direct Target Gene of Epstein-Barr Virus Nuclear Antigen 2

1999 • 268 citations

Notch as a Mediator of Cell Fate Determination in Hematopoiesis: Evidence and Speculation

1999 • 265 citations

Notch Inhibition of E47 Supports the Existence of a Novel Signaling Pathway

1998 • 261 citations

B-cell proliferation and induction of early G1-regulating proteins by Epstein-Barr virus mutants conditional for EBNA2.

1995 • 255 citations

Arbiter of differentiation and death: Notch signaling meets apoptosis

1999 • 255 citations

Epstein-Barr virus (EBV) induces expression of B-cell activation markers on in vitro infection of EBV-negative B-lymphoma cells.

1987 • 254 citations

Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by J kappa and PU.1

1995 • 250 citations

Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells

1992 • 246 citations

Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-J kappa, the homologue of Drosophila Suppressor of Hairless.

1994 • 218 citations

Epstein–Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter

2000 • 216 citations

A common enzyme connects Notch signaling and Alzheimer's disease

2000 • 214 citations

Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis.

1996 • 210 citations

Epstein-Barr virus nuclear protein LP stimulates EBNA-2 acidic domain-mediated transcriptional activation

1997 • 187 citations

The Epstein-Barr virus immortalizing protein EBNA-2 is targeted to DNA by a cellular enhancer-binding protein.

1993 • 187 citations

Stable transfection of Epstein-Barr virus (EBV) nuclear antigen 2 in lymphoma cells containing the EBV P3HR1 genome induces expression of B-cell activation molecules CD21 and CD23

1990 • 185 citations

Human Immunodeficiency Virus Type 1 Vectors Efficiently Transduce Human Hematopoietic Stem Cells

1998 • 176 citations

Oncogenic Forms of NOTCH1 Lacking Either the Primary Binding Site for RBP-Jκ or Nuclear Localization Sequences Retain the Ability to Associate with RBP-Jκ and Activate Transcription

1997 • 176 citations

Epstein-Barr virus-encoded nuclear antigen 2 activates the viral latent membrane protein promoter by modulating the activity of a negative regulatory element.

1990 • 168 citations

Epstein-Barr virus nuclear antigen 2 activates transcription of the terminal protein gene

1991 • 165 citations

EBNA-2 transactivates a lymphoid-specific enhancer in the BamHI C promoter of Epstein-Barr virus

1991 • 158 citations

The human J kappa recombination signal sequence binding protein (RBP-J kappa) targets the Epstein-Barr virus EBNA2 protein to its DNA responsive elements.

1994 • 151 citations

Ras pathway signals are required for notch-mediated oncogenesis

2000 • 150 citations

Role for the Epstein-Barr virus nuclear antigen 2 in viral promoter switching during initial stages of infection.

1991 • 142 citations

Notch and the Immune System

1999 • 141 citations

The Spi-1/PU.1 and Spi-B ets family transcription factors and the recombination signal binding protein RBP-J kappa interact with an Epstein-Barr virus nuclear antigen 2 responsive cis-element.

1994 • 138 citations

Epstein-Barr Virus Latent Gene Expression during the Initiation of B Cell Immortalization

1989 • 127 citations

Notch signalling via RBP-J promotes myeloid differentiation

2000 • 122 citations

An Epstein-Barr virus nuclear protein 2 domain essential for transformation is a direct transcriptional activator

1991 • 119 citations

Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation

1997 • 111 citations

A Role for SKIP in EBNA2 Activation of CBF1-Repressed Promoters

2000 • 111 citations

EBNA-2 of herpesvirus papio diverges significantly from the type A and type B EBNA-2 proteins of Epstein-Barr virus but retains an efficient transactivation domain with a conserved hydrophobic motif

1993 • 106 citations

Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements

1997 • 105 citations

Genetic and Biochemical Evidence That EBNA 2 Interaction with a 63-kDa Cellular GTG-Binding Protein Is Essential for B Lymphocyte Growth Transformation by EBV

1994 • 97 citations

Activated Notch1 Modulates Gene Expression in B Cells Similarly to Epstein-Barr Viral Nuclear Antigen 2

2000 • 93 citations

Three unrelated viral transforming proteins (vIRF, EBNA2, and E1A) induce the MYC oncogene through the interferon-responsive PRF element by using different transcription coadaptors

1999 • 91 citations

Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless

1997 • 90 citations

Delineation of the cis-acting element mediating EBNA-2 transactivation of latent infection membrane protein expression

1991 • 89 citations

Both Epstein-Barr Viral Nuclear Antigen 2 (EBNA2) and Activated Notch1 Transactivate Genes by Interacting with the Cellular Protein RBP-Jκ

1997 • 87 citations

Contribution of conserved amino acids in mediating the interaction between EBNA2 and CBF1/RBPJk

1995 • 78 citations

Sequence and Functional Analysis of EBNA-LP and EBNA2 Proteins from Nonhuman Primate Lymphocryptoviruses

2000 • 78 citations

Functional Replacement of the Intracellular Region of the Notch1 Receptor by Epstein-Barr Virus Nuclear Antigen 2

1998 • 77 citations

Regulation of the Epstein-Barr Virus C Promoter by AUF1 and the Cyclic AMP/Protein Kinase A Signaling Pathway

2000 • 75 citations

Activated Notch1 Can Transiently Substitute for EBNA2 in the Maintenance of Proliferation of LMP1-Expressing Immortalized B Cells

2001 • 71 citations

Epstein-Barr virus nuclear antigen 2 is a transcriptional suppressor of the immunoglobulin mu gene: implications for the expression of the translocated c-myc gene in Burkitt's lymphoma cells.

1996 • 69 citations

Activated Mouse Notch1 Transactivates Epstein-Barr Virus Nuclear Antigen 2-Regulated Viral Promoters

1999 • 51 citations

Epstein–Barr Virus Nuclear Antigen 2–Estrogen Receptor Fusion Proteins Transactivate Viral and Cellular Genes and Interact with RBP-Jκ in a Conditional Fashion

1995 • 51 citations

Conserved Regions in the Epstein-Barr Virus Leader Protein Define Distinct Domains Required for Nuclear Localization and Transcriptional Cooperation with EBNA2

2000 • 48 citations

Neoplastic transformation by Notch is independent of transcriptional activation by RBP-J signalling

2000 • 47 citations

The N-terminal half of EBNA2, except for seven prolines, is not essential for primary B-lymphocyte growth transformation

1996 • 29 citations

Intracellular Forms of Human NOTCH1 Functionally Activate Essential Epstein-Barr Virus Major Latent Promoters in the Burkitt's Lymphoma BJAB Cell Line but Repress These Promoters in Jurkat Cells

2000 • 11 citations

Notch

2000 • 7 citations