Antioxidant vitamins or lactulose for the prevention of the recurrence of colorectal adenomas

Regression Models and Life-Tables

1992 • 27,454 citations

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples

1977 • 8,468 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

The evolution of cancer of the colon and rectum

1975 • 2,120 citations

Natural history of untreated colonic polyps

1987 • 948 citations

13-cis-Retinoic Acid in the Treatment of Oral Leukoplakia

1986 • 825 citations

Effect of Added Dietary Calcium on Colonic Epithelial-Cell Proliferation in Subjects at High Risk for Familial Colonic Cancer

1985 • 479 citations

ÆTIOLOGY OF ADENOMA—CARCINOMA SEQUENCE IN LARGE BOWEL

1978 • 409 citations

Biomarkers of increased susceptibility to gastrointestinal cancer: new application to studies of cancer prevention in human subjects.

1988 • 380 citations

Rationale and strategies for chemoprevention of cancer in humans.

1987 • 366 citations

PRIMARY SEX-RATIO AND SIZE OF FAMILY

1970 • 366 citations

Evaluation of vitamin A toxicity

1990 • 363 citations

Correlation of the inhibition by retinoids of tumor promoter-induced mouse epidermal ornithine decarboxylase activity and of skin tumor promotion.

1979 • 361 citations

Multivariate survival analysis using Cox's regression model

1987 • 357 citations

Effect of Wheat Fiber and Vitamins C and E on Rectal Polyps in Patients With Familial Adenomatous Polyposis

1989 • 349 citations

Colorectal Cancer: Prevention, Epidemiology, and Screening.

1981 • 290 citations

Influence of chronic lactulose ingestion on the colonic metabolism of lactulose in man (an in vivo study).

1985 • 267 citations

HIGH COLONIC pH PROMOTES COLORECTAL CANCER

1981 • 220 citations

A randomized trial of vitamins C and E in the prevention of recurrence of colorectal polyps.

1988 • 204 citations

Distribution of human colonic lymphatics in normal, hyperplastic, and adenomatous tissue. Its relationship to metastasis from small carcinomas in pedunculated adenomas, with two case reports.

1973 • 196 citations

A randomized trial of ascorbic acid in polyposis coli

1982 • 194 citations

Distribution of Human Colonic Lymphatics in Normal, Hyperplastic, and Adenomatous Tissue

1973 • 179 citations

Pattern of epithelial cell proliferation in colorectal mucosa of normal subjects and of patients with adenomatous polyps or cancer of the large bowel.

1988 • 164 citations

Predisposing causes of intestinal cancer

1970 • 156 citations

Rat Colon Carcinomas Associated with Aflatoxin and Marginal Vitamin A 2 3

1973 • 145 citations

ETRETINATE IN TREATMENT OF ACTINIC KERATOSIS

1982 • 136 citations

Familial aggregation of tumors in the three-year experience of a population-based colorectal cancer registry.

1989 • 129 citations

Incidence and familial occurrence of colorectal cancer and polyps in a health-care district of Northern Italy

1987 • 129 citations

Polyps of the Large Intestine in Aarhus, Denmark

1989 • 113 citations

Effect of Vitamin A, C, and E Supplementation on Rectal Cell Proliferation in Patients With Colorectal Adenomas

1992 • 102 citations

Preventive role of vitamin a in colon carcinogenesis in rats

1977 • 89 citations

Protective Effect of Taurine, Zinc and Tocopherol on Retinol-Induced Damage in Human Lymphoblastoid Cells

1984 • 84 citations

The effect of dietary ascorbic acid and α-tocopherol on fecal mutagenicity

1982 • 82 citations

Recurrence rates for colorectal polyps

1985 • 71 citations

Long-term effects of dietary calcium on risk markers for colon cancer in patients with familial polyposis.

1990 • 67 citations

Inhibition of chemically induced morphological transformation and reversion of the transformed phenotype of ascorbic acid in C3H/10T 1/2 cells.

1980 • 66 citations

Hepatic encephalopathy: Management with lactulose and related carbohydrates

1989 • 55 citations

Diet and the human intestinal bacterial flora.

1981 • 47 citations

Effect of long term lactulose ingestion on secondary bile salt metabolism in man: potential protective effect of lactulose in colonic carcinogenesis.

1987 • 46 citations

Strategies for dietary intervention studies in colon cancer

1981 • 44 citations

Effect of the duration of retinyl acetate feeding on inhibition of 1-methyl-1-nitrosourea-induced mammary carcinogenesis in the rat.

1979 • 42 citations

Safety of High-Dose Vitamin A

1991 • 39 citations

Repeat colonoscopy after endoscopic polypectomy

1987 • 23 citations

Gastrointestinal Pathology

1990 • 19 citations