Influence of the Microporous Substratum and Hydrodynamics on Resistances to Drug Transport in Cell Culture Systems: Calculation of Intrinsic Transport Parameters

Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability

1989 • 2,127 citations

The Movement of Molecules Across Cell Membranes

1967 • 1,196 citations

Physicochemical Hydrodynamics

1963 • 1,066 citations

Epithelial Transport Of Drugs In Cell Culture. I: A Model For Studying The Passive Diffusion Of Drugs Over Intestinal Absorbtive (Caco-2) Cells

1990 • 820 citations

Statistical Concepts and Methods

1980 • 717 citations

Caco-2 cell monolayers as a model for drug transport across the intestinal mucosa.

1990 • 565 citations

Statistical Concepts and Methods.

1978 • 429 citations

Characterization of the enterocyte-like brush border cytoskeleton of the C2BBe clones of the human intestinal cell line, Caco-2

1992 • 375 citations

Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators

1993 • 365 citations

Intestinal absorption and secretion

1991 • 365 citations

The use of cultured epithelial and endothelial cells for drug transport and metabolism studies.

1990 • 272 citations

Transport and permeability properties of human Caco-2 cells: An in vitro model of the intestinal epithelial cell barrier

1990 • 234 citations

Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes

1980 • 220 citations

In vitro systems for studying intestinal drug absorption

1995 • 178 citations

A method for the determination of cellular permeability coefficients and aqueous boundary layer thickness in monolayers of intestinal epithelial ( Caco-2) cells grown in permeable filter chambers

1991 • 175 citations

Transport of a large neutral amino acid (phenylalanine) in a human intestinal epithelial cell line: Caco-2

1990 • 163 citations

Passive Diffusion of Weak Organic Electrolytes across Caco‐2 Cell Monolayers: Uncoupling the Contributions of Hydrodynamic, Transcellular, and Paracellular Barriers

1995 • 153 citations

Determinants of intestinal mucosal uptake of short- and medium-chain fatty acids and alcohols

1973 • 150 citations

Evidence for diminished functional expression of intestinal transporters in Caco-2 cell monolayers at high passages.

1997 • 122 citations

Calculation of unstirred layer thickness in membrane transport experiments: a survey

1983 • 120 citations

The Transport of Vitamin B12 Through Polarized Monolayers of Caco-2 Cells

1990 • 109 citations

Heterogeneity in the human intestinal cell line Caco-2 leads to differences in transepithelial transport

1995 • 95 citations

Sodium-dependent, concentrative nucleoside transport in cultured intestinal epithelial cells

1986 • 76 citations

A new diffusion chamber system for the determination of drug permeability coefficients across the human intestinal epithelium that are independent of the unstirred water layer

1992 • 65 citations

H⁺‐coupled (Na⁺‐independent) proline transport in human intestinal (Caco‐2) epithelial cell monolayers

1993 • 63 citations

Animal models for oral drug delivery in man : in situ and in vivo approaches

1983 • 53 citations

Relationship of octanol/buffer and octanol/water partition coefficients to transcellular diffusion across brain microvessel endothelial cell monolayers

1986 • 53 citations

Cell culture techniques for the study of drug transport

1990 • 50 citations

Advancing quantitative and mechanistic approaches in interfacing gastrointestinal drug absorption studies in animals and humans

1983 • 49 citations

Proline uptake by monolayers of human intestinal absorptive (Caco-2) cells in vitro

1992 • 47 citations

Pharmaceutical Applications of Cell and Tissue Culture to Drug Transport

1991 • 47 citations

Use of formycin B as a general substrate for measuring facilitated nucleoside transport in mammalian cells

1989 • 39 citations

Improved cultivation of polarized animal cells on culture inserts with new transparent polyethylene terephthalate or polycarbonate microporous membranes

1990 • 29 citations

Permeable support type influences the transport of compounds across Caco-2 cells

1992 • 26 citations

Mechanism and site dependency of intestinal mucosal transport and metabolism of thymidine analogues.

1992 • 26 citations

Gastrointestinal and hepatic first-pass elimination of 2',3'-dideoxyinosine in rats.

1993 • 25 citations

Pharmaceutical Applications of Cell Culture: An Overview

1991 • 19 citations

Metabolism of progesterone, 17-hydroxyprogesterone and deoxycorticosterone by human small intestine in vitro

1980 • 16 citations

Determination intestinal metabolism and permeability for several compounds in rats. Implications on regional bioavailability in humans.

1996 • 16 citations

Influence of filter supports on transport characteristics of cultured A6 kidney cells

1993 • 15 citations