Development of a colorimetric test system for detection of point mutations via ligation of a tandem of short oligonucleotides on methacrylate beads

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

1989 • 3,707 citations

A Ligase-Mediated Gene Detection Technique

1988 • 834 citations

Handbook of biochemistry and molecular biology. Nucleic acids - v. 1 - 3. ed.

1975 • 423 citations

Sequencing of megabase plus DNA by hybridization: Theory of the method

1989 • 352 citations

Universal DNA microarray method for multiplex detection of low abundance point mutations

1999 • 346 citations

The ligation amplification reaction (LAR)—Amplification of specific DNA sequences using sequential rounds of template-dependent ligation

1989 • 258 citations

An oligonucleotide hybridization approach to DNA sequencing

1989 • 232 citations

Multiplex PCR/LDR for detection of K-ras mutations in primary colon tumors

1999 • 166 citations

Specificity of the nick-closing activity of bacteriophage T4 DNA ligase

1989 • 163 citations

PCR amplification of specific alleles: Rapid detection of known mutations and polymorphisms

1993 • 120 citations

Oligonucleotides and Analogues

1991 • 110 citations

Detection of single base changes in nucleic acids

1989 • 99 citations

Sequence analysis by hybridization with oligonucleotide microchip: identification of β-thalassemia mutations

1997 • 92 citations

Polymorphic DNA haplotypes at the phenylalanine hydroxylase (PAH) locus in Asian families with phenylketonuria (PKU).

1989 • 71 citations

Fractionation, phosphorylation and ligation on oligonucleotide microchips to enhance sequencing by hybridization

1997 • 57 citations

Unexpected substrate specificity of T4 DNA ligase revealed byin vitroselection

1993 • 53 citations

PKU mutation G46S is associated with increased aggregation and degradation of the phenylalanine hydroxylase enzyme

1996 • 52 citations

Molecular basis of phenylketonuria and a correlation between genotype and phenotype in a heterogeneous southeastern US population.

1996 • 44 citations

The use of chemical reagents in the detection of DNA mutations

1993 • 40 citations

The fidelity of template-directed oligonucleotide ligation and its relevance to DNA computation

1998 • 31 citations

CCR: a rapid and simple approach for mutation detection

1997 • 27 citations

Oligonucleotide micro-arrays for identification of unknown mutations: how far from reality?

1997 • 25 citations

Robust nonradioactive oligonucleotide ligation assay to detect a common point mutation in the CYP2D6 gene causing abnormal drug metabolism

1995 • 24 citations

A fluorescent multiplex ARMS method for rapid mutation analysis

1995 • 14 citations

A simple method to detect the RYR1 mutation G1021A, a cause of malignant hyperthermia susceptibility

1995 • 11 citations

Distribution of Some Point Mutations in the Phenylalanine Hydroxylase Gene of Phenylketonuria Patients from the Moscow Region

1993 • 10 citations

CHEMICAL REACTIONS IN NUCLEIC ACID DUPLEXES. 2. SELECTIVE MODIFICATIONS OF THE DNA SUGAR-PHOSPHATE BACKBONE

1986 • 6 citations

[T4-DNA ligase: substrate properties of synthetic DNA-duplexes with structural anomalies].

1988 • 5 citations

Direct analysis of R408W mutation in phenylalanine hydroxylase gene by allele-specific PCR amplification

1993 • 4 citations

[A simple and reliable method for detection of the R408W mutation in exon 12 of the phenylalanine hydroxylase gene in the molecular diagnosis of phenylketonuria].

1993 • 3 citations

Molecular screening of genetic defects with RNA–SSCP analysis: the PKU and cystinuria model

1995 • 3 citations

[Features of connecting short oligonucleotides with phage T4 DNA ligase].

1993 • 2 citations

[The spectrum of mutational damage to the phenylalanine hydroxylase gene in patients with phenylketonuria in St. Petersburg].

1995 • 2 citations