Specification of Neurotransmitter Identity by Phox2 Proteins in Neural Crest Stem Cells

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

The regulation and function of c-fos and other immediate early genes in the nervous system

1990 • 2,392 citations

The Neuron-Restrictive Silencer Factor (NRSF): A Coordinate Repressor of Multiple Neuron-Specific Genes

1995 • 1,078 citations

REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons

1995 • 1,078 citations

Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons

1993 • 1,019 citations

TRANSCRIPTIONAL REGULATION BY CYCLIC AMP

1997 • 967 citations

Crx, a Novel otx-like Homeobox Gene, Shows Photoreceptor-Specific Expression and Regulates Photoreceptor Differentiation

1997 • 882 citations

FGF and Shh Signals Control Dopaminergic and Serotonergic Cell Fate in the Anterior Neural Plate

1998 • 868 citations

Isolation of a stem cell for neurons and glia from the mammalian neural crest

1992 • 796 citations

Alternative Neural Crest Cell Fates Are Instructively Promoted by TGFβ Superfamily Members

1996 • 785 citations

Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis

1997 • 561 citations

Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors

1990 • 533 citations

Progression from Extrinsic to Intrinsic Signaling in Cell Fate Specification

1999 • 495 citations

NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis

1998 • 454 citations

Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neural crest cells.

1991 • 441 citations

LIM Homeodomain Factors Lhx3 and Lhx4 Assign Subtype Identities for Motor Neurons

1998 • 438 citations

Identification of potential target genes for the neuron-restrictive silencer factor.

1996 • 411 citations

Involvement of bone morphogenetic protein-4 and bone morphogenetic protein-7 in the differentiation of the adrenergic phenotype in developing sympathetic neurons

1996 • 359 citations

Specification of Motor Neuron Identity by the MNR2 Homeodomain Protein

1998 • 340 citations

Defects in Sensory and Autonomic Ganglia and Absence of Locus Coeruleus in Mice Deficient for the Homeobox Gene Phox2a

1997 • 330 citations

Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMP.

1987 • 328 citations

Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system

1998 • 321 citations

Molecular and Cellular Approaches to Neural Development

1998 • 300 citations

The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype

1993 • 290 citations

The Expression Pattern of the Transcription Factor Phox2 Delineates Synaptic Pathways of the Autonomic Nervous System

1996 • 287 citations

The Drosophila islet Gene Governs Axon Pathfinding and Neurotransmitter Identity

1997 • 283 citations

Functional domains of the Drosophila Engrailed protein.

1993 • 280 citations

MASH1 activates expression of the paired homeodomain transcription factor Phox2a, and couples pan-neuronal and subtype-specific components of autonomic neuronal identity

1998 • 263 citations

The cellular function of MASH1 in autonomic neurogenesis

1995 • 241 citations

X-MyT1, a Xenopus C2HC-Type Zinc Finger Protein with a Regulatory Function in Neuronal Differentiation

1996 • 236 citations

Both the basal and inducible transcription of the tyrosine hydroxylase gene are dependent upon a cAMP response element

1993 • 207 citations

A v-myc-immortalized sympathoadrenal progenitor cell line in which neuronal differentiation is initiated by FGF but not NGF

1990 • 205 citations

Tissue-specific transcription of the rat tyrosine hydroxylase gene requires synergy between an AP-1 motif and an overlapping E box-containing dyad

1992 • 175 citations

Dominant interfering alleles define a role for c-Myb in T-cell development.

1994 • 172 citations

Postmigratory neural crest cells expressing c-RET display restricted developmental and proliferative capacities

1995 • 169 citations

MASH1 maintains competence for BMP2-induced neuronal differentiation in post-migratory neural crest cells

1997 • 166 citations

DNA binding and transcriptional regulatory activity of mammalian achaete-scute homologous (MASH) proteins revealed by interaction with a muscle-specific enhancer.

1992 • 152 citations

Differential regulation of transcription factor gene expression and phenotypic markers in developing sympathetic neurons

1995 • 152 citations

Combinatorial control of touch receptor neuron expression in Caenorhabditis elegans

1993 • 143 citations

Paired‐Like Homeodomain Proteins, Phox2a and Phox2b, Are Responsible for Noradrenergic Cell‐Specific Transcription of the Dopamine β‐Hydroxylase Gene

1998 • 136 citations

BMP-2 and BMP-4, but Not BMP-6, Increase the Number of Adrenergic Cells Which Develop in Quail Trunk Neural Crest Cultures

1996 • 133 citations

5′ Upstream DNA sequence of the rat tyrosine hydroxylase gene directs high-level and tissue-specific expression to catecholaminergic neurons in the central nervous system of transgenic mice

1994 • 124 citations

Neuron-specific expression of the human dopamine beta-hydroxylase gene requires both the cAMP-response element and a silencer region.

1993 • 120 citations

Noradrenergic-specific transcription of the dopamine beta-hydroxylase gene requires synergy of multiple cis-acting elements including at least two Phox2a-binding sites.

1998 • 111 citations

Transcriptional control of neurotransmitter phenotype

1999 • 109 citations

Number of adrenergic and Islet‐1 immunoreactive cells is increased in avian trunk neural crest cultures in the presence of human recombinant osteogenic protein‐1

1995 • 105 citations

A homeodomain protein selectively expressed in noradrenergic tissue regulates transcription of neurotransmitter biosynthetic genes

1995 • 103 citations

Noradrenergic-Specific Transcription of the Dopamine β-Hydroxylase Gene Requires Synergy of MultipleCis-Acting Elements Including at Least Two Phox2a-Binding Sites

1998 • 103 citations

5' flanking sequences of the rat tyrosine hydroxylase gene target accurate tissue-specific, developmental, and transsynaptic expression in transgenic mice

1992 • 99 citations

Sequences That Direct Rat Tyrosine Hydroxylase Gene Expression

1992 • 97 citations

The Cyclic AMP Response Element Directs Tyrosine Hydroxylase Expression in Catecholaminergic Central and Peripheral Nervous System Cell Lines from Transgenic Mice

1995 • 96 citations

Tissue interactions affecting the migration and differentiation of neural crest cells in the chick embryo

1991 • 90 citations

Molecular Basis of Neural-Specific Gene Expression

1993 • 86 citations

The Homeodomain Protein Arix Interacts Synergistically with Cyclic AMP to Regulate Expression of Neurotransmitter Biosynthetic Genes

1997 • 74 citations

The determination of the neuronal phenotype

1998 • 57 citations

Glial cell line-derived neurotrophic factor promotes the development of adrenergic neurons in mouse neural crest cultures

1996 • 53 citations

NEURONAL-SPECIFIC GENE EXPRESSION μ THE INTERACTION OF BOTH POSITIVE AND NEGATIVE TRANSCRIPTIONAL REGULATORS

1996 • 48 citations

GDNF in a Bind with Known Orphan: Accessory Implicated in New Twist

1996 • 40 citations

DNA regulatory sequences of the rat tyrosine hydroxylase gene direct correct catecholaminergic cell-type specificity of a human growth hormone reporter in the CNS of transgenic mice causing a dwarf phenotype

1994 • 39 citations

Species and Regional Differences in the Expression of Cell‐Type Specific Elements at the Human and Rat Tyrosine Hydroxylase Gene Loci

1990 • 39 citations

Glucocorticoids stimulate adrenergic differentiation in cultures of migrating and premigratory neural crest

1984 • 38 citations

Neurotrophin-3- and norepinephrine-mediated adrenergic differentiation and the inhibitory action of desipramine and cocaine

1997 • 33 citations

V-myc immortalization of early rat neural crest cells yields a clonal cell line which generates both glial and adrenergic progenitor cells

1991 • 30 citations

Identification of a negative regulatory element in the 5′-flanking region of the human dopamine β-hydroxylase gene

1995 • 26 citations

Positive and negative elements contribute to the cell-specific expression of the rat dopamine β-hydroxylase gene

1996 • 25 citations

Characterization of the norepinephrine uptake system and the role of norepinephrine in the expression of the adrenergic phenotype by quail neural crest cells in clonal culture

1992 • 21 citations

The 3′ Flanking Region of the Human Tyrosine Hydroxylase Gene Directs Reporter Gene Expression in Peripheral Neuroendocrine Tissues

1995 • 21 citations

A Negative Regulatory Element in the Rat Dopamine β‐Hydroxylase Gene Contributes to the Cell Type Specificity of Expression

1995 • 19 citations

Requirement for cAMP/calcium response element but not AP-1 site in fibroblast growth factor-2-elicited activation of tyrosine hydroxylase gene expression in PC12 cells

1997 • 14 citations

Molecular and Cellular Approaches to Neural Development

1998 • 14 citations