Back to search

Differential effects of antisense oligodeoxynucleotides directed against Gzα and Goα on antinociception produced by spinal opioid and α2 adrenergic receptor agonists

Data up to Jan 2025

Published2000
Citations28
References44

Total Citations Per Year

Abstract

References (44)

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

1941 • 3,174 citations

Intrathecal morphine in mice: A new technique

1980 • 1,880 citations

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

1996 • 1,652 citations

MYELINATION IN RAT BRAIN: METHOD OF MYELIN ISOLATION1

1973 • 1,412 citations

Alpha-2 adrenoceptor agonists: defining the role in clinical anesthesia.

1991 • 710 citations

CLONIDINE BLOCKS ACUTE OPIATE-WITHDRAWAL SYMPTOMS

1978 • 705 citations

Alpha-2 Adrenoceptor Agonists

1991 • 550 citations

Ion channel regulation by G proteins

1995 • 408 citations

Statistical analysis of drug-drug and site-site interactions with isobolograms

1989 • 368 citations

μ Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality

1998 • 332 citations

Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins

1997 • 276 citations

G z -Mediated Hormonal Inhibition of Cyclic AMP accumulation

1992 • 258 citations

IMMUNOLOGICAL FEATURES OF WEGENER'S GRANULOMATOSIS

1974 • 239 citations

Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein alpha subunit.

1988 • 207 citations

Opioid tolerance: the clinical perspective

1998 • 207 citations

Activity of the δ-Opioid Receptor Is Partially Reduced, Whereas Activity of the κ-Receptor Is Maintained in Mice Lacking the μ-Receptor

1998 • 193 citations

Pharmacological characterization of substance P-induced nociception in mice: modulation by opioid and noradrenergic agonists at the spinal level.

1983 • 193 citations

Pertussis toxin and voltage dependence distinguish multiple pathways modulating calcium channels of rat sympathetic neurons

1992 • 192 citations

Coupling of the alpha 2A-adrenergic receptor to multiple G-proteins. A simple approach for estimating receptor-G-protein coupling efficiency in a transient expression system.

1994 • 150 citations

The μ-opioid receptor is necessary for [d-Pen2,d-Pen5]enkephalin-induced analgesia

1997 • 126 citations

Regulation of Multiple Effectors by the Cloned δ‐Opioid Receptor: Stimulation of Phospholipase C and Type II Adenylyl Cyclase

1995 • 116 citations

Differential blockade of opioid analgesia by antisense oligodeoxynucleotides directed against various G protein alpha subunits.

1996 • 115 citations

Intraoperative clonidine enhances postoperative morphine patient-controlled analgesia

1992 • 115 citations

Multiplicative interaction between intrathecally and intracerebroventricularly administered mu opioid agonists but limited interactions between delta and kappa agonists for antinociception in mice.

1989 • 103 citations

In vivo injection of antisense oligodeoxynucleotides to G alpha subunits and supraspinal analgesia evoked by mu and delta opioid agonists.

1995 • 101 citations

G-protein antisense oligodeoxyribonucleotides and μ-opioid supraspinal antinociception

1994 • 91 citations

Oral clonidine reduces postoperative PCA morphine requirements

1996 • 87 citations

Identification of three separate guanine nucleotide-binding proteins that interact with the delta-opioid receptor in NG108-15 neuroblastoma x glioma hybrid cells.

1992 • 80 citations

Pertussis toxin inhibits antinociception produced by intrathecal injection of morphine, noradrenaline and baclofen

1988 • 79 citations

Characterization of mechanical withdrawal responses and effects of μ-, δ- and κ-opioid agonists in normal and μ-opioid receptor knockout mice

1999 • 65 citations

Endomorphin-1 and endomorphin-2 show differences in their activation of mu opioid receptor-regulated G proteins in supraspinal antinociception in mice.

1999 • 60 citations

Absence of G‐protein activation by μ‐opioid receptor agonists in the spinal cord of μ‐opioid receptor knockout mice

1999 • 56 citations

Morphine antinociception in different strains of mice: relationship of supraspinal-spinal multiplicative interaction to tolerance.

1988 • 50 citations

Spinal morphine/clonidine antinociceptive synergism: involvement of G proteins and N-type voltage-dependent calcium channels.

1996 • 43 citations

Influence of Gz and Gi2 transducer proteins in the affinity of opioid agonists to μ receptors

1998 • 41 citations

Changes in the association of G protein subunits with the cloned mouse delta opioid receptor on agonist stimulation.

1997 • 39 citations

GX/Z and Gi2 transducer proteins on μ/δ opioid-mediated supraspinal antinociception

1993 • 37 citations

Immunohistochemical distribution of neurons containing the G-proteins Gqα/G11α in the adult rat brain

1992 • 35 citations

Specificity of interaction between receptor and G protein: use of antisense techniques to relate G-protein subunits to function

1996 • 34 citations

Intracerebroventricular injection of antibodies directed against Gsα enhances the supraspinal antinociception induced by morphine, β-endorphin and clonidine in mice

1992 • 23 citations

ω-Agatoxin IVA blocks spinal morphine/clonidine antinociceptive synergism

1996 • 12 citations

Opioid Regulation of Second Messenger Systems

1998 • 8 citations

α-Subunit G-protein antisense oligodeoxynucleotide effects on supraspinal (i.c.v.) α2-adrenoceptor antinociception in mice

1995 • 8 citations

Cited By (0)

Loading...