Preventing neural tube defects: The importance of periconceptional folic acid supplements

Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation

1992 • 3,145 citations

Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group.

1991 • 1,717 citations

Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida

1995 • 870 citations

Neurologic Aspects of Cobalamin Deficiency

1991 • 761 citations

Folate Levels and Neural Tube Defects

1995 • 747 citations

Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects.

1981 • 678 citations

Homocysteine metabolism in pregnancies complicated by neural-tube defects

1995 • 641 citations

Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects

1989 • 629 citations

Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease.

1991 • 615 citations

Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase.

1988 • 607 citations

Vitamin dificiencies and neural tube defects.

1976 • 580 citations

Periconceptional Use of Multivitamins and the Occurrence of Neural Tube Defects

1988 • 487 citations

Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects.

1993 • 486 citations

Periconceptional Folic Acid Exposure and Risk of Occurrent Neural Tube Defects

1993 • 405 citations

Maternal hyperhomocysteinemia: A risk factor for neural-tube defects?

1994 • 402 citations

PERICONCEPTIONAL VITAMIN USE, DIETARY FOLATE, AND THE OCCURRENCE OF NEURAL TUBE DEFECTS

1995 • 399 citations

Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease Effects of pyridoxine and folic acid treatment

1990 • 397 citations

Evidence for multi‐site closure of the neural tube in humans

1993 • 393 citations

Homocysteine induces congenital defects of the heart and neural tube: Effect of folic acid

1996 • 372 citations

Folic acid—an innocuous means to reduce plasma homocysteine

1988 • 368 citations

Dietary folate as a risk factor for neural‐tube defects: evidence from a case‐control study in Western Australia

1989 • 353 citations

Thermolabile variant of 5, 10-methylenetetrahydrofolate reductaseassociated with low red-cell folates: implications for folate intake recommendations

1997 • 346 citations

A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects

1995 • 314 citations

Epidemiology and Control of Neural Tube Defects

1992 • 296 citations

The Absence of a Relation between the Periconceptional Use of Vitamins and Neural-Tube Defects

1989 • 256 citations

5,10 Methylenetetrahydrofolate reductase genetic polymorphism as a risk factor for neural tube defects

1996 • 224 citations

Folate intake and food sources in the US population

1989 • 193 citations

Primary prevention of neural tube defects with folic acid supplementation: Cuban experience

1990 • 190 citations

A randomised trial of low dose folic acid to prevent neural tube defects. The Irish Vitamin Study Group.

1992 • 167 citations

Results of an international round robin for serum and whole-blood folate

1996 • 164 citations

Folic Acid Fortification of the Food Supply

1996 • 162 citations

Is disordered folate metabolism the basis for the genetic predisposition to neural tube defects?

1987 • 160 citations

Increased risk of recurrence of pregnancies complicated by fetal neural tube defects in mothers receiving poor diets, and possible benefit of dietary counselling.

1980 • 141 citations

Methionine but Not Folinic Acid or Vitamin B-12 Alters the Frequency of Neural Tube Defects in Axd Mutant Mice

1993 • 116 citations

Recommended dietary intakes (RDI) of folate in humans

1987 • 114 citations

Folates in foods: reactivity, stability during processing, and nutritional implications.

1989 • 109 citations

Methionine and neural tube closure in cultured rat embryos: Morphological and biochemical analyses

1990 • 107 citations

Blood folic acid and vitamin B12 in relation to neural tube defects

1996 • 89 citations

Can terathanasia explain the protective effect of folic-acid supplementation on birth defects?

1997 • 89 citations

Vitamin B₁₂ deficiency is the primary cause of megaloblastic anaemia in Zimbabwe

1994 • 86 citations

Reduction of plasma lipid and homocysteine levels by pyridoxine, folate, cobalamin, choline, riboflavin, and troxerutin in atherosclerosis

1989 • 78 citations

Predictors of Red Cell Folate Level in Women Attempting Pregnancy

1997 • 70 citations

The long-term evaluation of folic acid in the treatment of pernicious anemia.

1950 • 49 citations

Pyridoxine treatment does not prevent homocystinemia after methionine loading in adult homocystinuria patients

1983 • 35 citations

Folate metabolism in humans

1984 • 26 citations

Long term effects of periconceptional multivitamin supplements for prevention of neural tube defects: a seven to 10 year follow up.

1992 • 26 citations