Hyperforin inhibits vesicular uptake of monoamines by dissipating pH gradient across synaptic vesicle membrane

Methods in Enzymology , Vol

1966 • 26,261 citations

St John's wort for depression--an overview and meta-analysis of randomised clinical trials

1996 • 1,009 citations

Hyperforin as a possible antidepressant component of hypericum extracts

1998 • 445 citations

Catecholamine uptake by synaptosomes in homogenates of rat brain: stereospecificity in different areas.

1969 • 445 citations

Vacuolar and Plasma Membrane Proton-Adenosinetriphosphatases

1999 • 417 citations

Effects of Hypericum Extract (LI 160) in Biochemical Models of Antidepressant Activity

1997 • 281 citations

Hyperforin Represents the Neurotransmitter Reuptake Inhibiting Constituent of Hypericum Extract

1998 • 269 citations

Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis

2002 • 263 citations

Hyperforin, a major antidepressant constituent of St. John's Wort, inhibits serotonin uptake by elevating free intracellular Na+1.

1999 • 230 citations

Effects of the Total Extract and Fractions ofHypericum perforatumin Animal Assays for Antidepressant Activity

1997 • 194 citations

St. John's wort and depression

2002 • 191 citations

Controlled Clinical Trials of Hypericum Extracts in Depressed Patients - an Overview

1997 • 168 citations

Comparison of an extract of hypericum (LI 160) and sertraline in the treatment of depression: A double-blind, randomized pilot study

2000 • 167 citations

LI 160, an Extract of St. John's Wort, Versus Amitriptyline in Mildly to Moderately Depressed Outpatients - A Controlled 6-Week Clinical Trial

1997 • 151 citations

A Molecular Glimpse of Vesicular Monoamine Transporters

1994 • 148 citations

Efficacy and Tolerability of St. John's Wort Extract LI 160 Versus Imipramine in Patients with Severe Depressive Episodes According to ICD-10

1997 • 141 citations

Role of Mg²⁺ion-activated ATPase and a pH gradient in the storage of catecholamines in synaptic vesicles

1978 • 135 citations

Characterization of a H+-ATPase in rat brain synaptic vesicles

1989 • 132 citations

St. John's Wort, an anti-depressant? A systematic, criteria-based review

1995 • 116 citations

Hyperforin enhances the extracellular concentrations of catecholamines, serotonin and glutamate in the rat locus coeruleus

1999 • 106 citations

Dihydrotetrabenazine Binding and Monoamine Uptake in Mouse Brain Regions

1986 • 100 citations

Activity Profiles of Two Hyperforin-Containing Hypericum Extracts in Behavioral Models

1998 • 97 citations

Effects of Hypericum perforatum on Levels of 5-Hydroxytryptamine, Noradrenaline and Dopamine in the Cortex, Diencephalon and Brainstem of the Rat

1999 • 87 citations

High‐Affinity Binding of [3H]Desipramine to Rat Brain: A Presynaptic Marker for Noradrenergic Uptake Sites

1982 • 85 citations

Hypericum perforatum L. extract does not inhibit 5-HT transporter in rat brain cortex

1999 • 80 citations

Hypericum LI 160 inhibits uptake of serotonin and norepinephrine in astrocytes

1999 • 80 citations

St. John's Wort (Hypericum perforatum): clinical effects on depression and other conditions.

1998 • 77 citations

Hypericum for depression

1999 • 70 citations

Pharmacodynamic Effects of two Different Hypericum Extracts in Healthy Volunteers Measured by Quantitative EEG

1998 • 50 citations

Inhibition of vesicular uptake of monoamines by hyperforin

2002 • 46 citations

Stimulation of Glutamate, Aspartate and Gamma-Aminobutyric Acid Release from Synaptosomes by Hyperforin

2001 • 45 citations

[48] Chromaffin granule proton pump

1988 • 26 citations

Effects of a Methanolic Extract and a Hyperforin-Enriched CO₂Extract of St. John's Wort (Hypericum perforatum) on Intracerebral Field Potentials in the Freely Moving Rat (Tele-Stereo-EEG)

1998 • 25 citations