Des-γ-carboxy (abnormal) prothrombin and hepatocellular carcinoma: A critical review

Hepatogastroenterology

2012 • 2,302 citations

The molecular basis of blood coagulation

1988 • 1,240 citations

Vitamin K Dependent Modifications of Glutamic Acid Residues in Prothrombin

1974 • 750 citations

Des-γ-Carboxy (Abnormal) Prothrombin as a Serum Marker of Primary Hepatocellular Carcinoma

1984 • 576 citations

COFACTOR PROTEINS IN THE ASSEMBLY AND EXPRESSION OF BLOOD CLOTTING ENZYME COMPLEXES

1988 • 535 citations

The Mode of Action of Vitamin K

1974 • 527 citations

Hemostasis and Thrombosis, Basic Principles and Clinical Practice

1983 • 450 citations

Role of gamma-carboxyglutamic acid. An unusual protein transition required for the calcium-dependent binding of prothrombin to phospholipid.

1976 • 278 citations

Molecular basis of vitamin K-dependent gamma-carboxylation

1990 • 231 citations

Molecular basis of vitamin K-dependent gamma-carboxylation

1990 • 224 citations

Acquired Vitamin K-Dependent Carboxylation Deficiency in Liver Disease

1981 • 224 citations

Cloning and Expression of the cDNA for Human γ-glutamyl Carboxylase

1991 • 204 citations

Recognition site directing vitamin K-dependent γ-carboxylation resides on the propeptide of factor IX

1987 • 199 citations

Gross anatomic features of hepatocellular carcinoma from three disparate geographic areas. Proposal of new classification

1984 • 162 citations

Hepatocellular carcinoma diagnostic and prognostic features in north american patients

1984 • 154 citations

Plasma prothrombin during treatment with Dicumarol. II. Demonstration of an abnormal prothrombin fraction.

1968 • 145 citations

The Purification and Properties of an Abnormal Prothrombin Protein Produced by Dicumarol-treated Cows

1972 • 141 citations

Molecular basis of hemophilia B: a defective enzyme due to an unprocessed propeptide is caused by a point mutation in the factor IX precursor.

1986 • 129 citations

Plasma Prothrombin during Treatment with Dicumarol

1968 • 126 citations

Prothrombin requires two sequential metal-dependent conformational transitions to bind phospholipid. Conformation-specific antibodies directed against the phospholipid-binding site on prothrombin.

1986 • 124 citations

Detection of Vitamin K Deficiency by Use of an Enzyme-Linked Immunosorbent Assay for Circulating Abnormal Prothrombin

1985 • 117 citations

Presence of cross-reactive antibody between human immunodeficiency virus (HIV) and platelet glycoproteins in HIV-related immune thrombocytopenic purpura

1992 • 113 citations

Presence of cross-reactive antibody between human immunodeficiency virus (HIV) and platelet glycoproteins in HIV-related immune thrombocytopenic purpura

1992 • 112 citations

Detection of hepatocellular carcinoma during a clinical follow-up of chronic liver disease

1978 • 112 citations

Plasma abnormal prothrombin (Des-γ-carboxy prothrombin) as a marker of hepatocellular carcinoma

1988 • 110 citations

Plasma des-γ-carboxyprothrombin in the early stage of hepatocellular carcinoma

1990 • 105 citations

Production of abnormal prothrombin (des-γ-carboxy prothrombin) by hepatocellular carcinoma

1987 • 98 citations

Vitamin K-dependent carboxylation. A synthetic peptide based upon the gamma-carboxylation recognition site sequence of the prothrombin propeptide is an active substrate for the carboxylase in vitro.

1988 • 91 citations

Immunoassays of human prothrombin species which correlate with functional coagulant activities.

1983 • 77 citations

A New Method to Assay Des-γ-carboxyprothrombin

1986 • 71 citations

Conformation-specific antibodies as probes of the gamma-carboxyglutamic acid-rich region of bovine prothrombin. Studies of metal-induced structural changes.

1979 • 61 citations

Metal and phospholipid binding properties of partially carboxylated human prothrombin variants.

1985 • 59 citations

Factor IX San Dimas

1989 • 57 citations

Isolation and characterization of a hepatoma-associated abnormal (des-gamma-carboxy)prothrombin.

1989 • 52 citations

Changes of plasma des-γ-carboxy prothrombin levels in patients with hepatocellular carcinoma in response to vitamin K

1992 • 43 citations

Distribution of gamma-carboxyglutamic acid residues in partially carboxylated human prothrombins.

1986 • 41 citations

Clinical evaluation of plasma abnormal prothrombin (des-gamma-carboxy prothrombin) in hepatobiliary malignancies and other diseases.

1991 • 41 citations

Abnormal prothrombin in the plasma of rats carrying hepatic tumors

1987 • 34 citations

Measurement of immunoreactive prothrombin, des-gamma-carboxy prothrombin, and vitamin K in human liver tissues: overproduction of immunoreactive prothrombin in hepatocellular carcinoma.

1990 • 31 citations

Evaluation of des-γ-carboxy prothrombin as a marker protein of hepatocellular carcinoma

1989 • 28 citations

Plasma abnormal prothrombin levels in patients with small hepatocellular carcinoma.

1988 • 26 citations

The acquired vitamin K-dependent γ-carboxylation deficiency in hepatocellular carcinoma involves not only prothrombin, but also protein C

1988 • 20 citations

Hepatic Vitamin K-Dependent Carboxylation of Blood-Clotting Proteins

1982 • 20 citations

Specificity of increased des-gamma-carboxyprothrombin in hepatocellular carcinoma after vitamin K1 injection

1987 • 17 citations

Nucleotide sequence of prothrombin gene in abnormal prothrombin-producing hepatocellular carcinoma cell lines

1992 • 12 citations

Vitamin K‐dependent proteins and hepatocellular carcinoma

1991 • 12 citations

Vitamin K-Dependent Carboxylase: Liver Activity in Various Species

1979 • 11 citations

[Assay of decarboxy-prothrombin: its value in the diagnosis of hepatocellular carcinoma].

1988 • 1 citations