Nucleotide sequence of prothrombin gene in abnormal prothrombin-producing hepatocellular carcinoma cell lines

Proteases and biological control

1976 • 1,380 citations

Vitamin K Dependent Modifications of Glutamic Acid Residues in Prothrombin

1974 • 750 citations

Des-γ-Carboxy (Abnormal) Prothrombin as a Serum Marker of Primary Hepatocellular Carcinoma

1984 • 576 citations

The Mode of Action of Vitamin K

1974 • 527 citations

Establishment of a continuously growing cell line from primary carcinoma of the liver.

1976 • 335 citations

Nucleotide sequence of the gene for human prothrombin

1987 • 258 citations

Acquired Vitamin K-Dependent Carboxylation Deficiency in Liver Disease

1981 • 224 citations

Recognition site directing vitamin K-dependent γ-carboxylation resides on the propeptide of factor IX

1987 • 199 citations

The propeptide of rat bone gamma-carboxyglutamic acid protein shares homology with other vitamin K-dependent protein precursors.

1985 • 195 citations

Defective propeptide processing of blood clotting factor IX caused by mutation of arginine to glutamine at position −4

1986 • 176 citations

Analysis of ras gene mutations in human hepatic malignant tumors by polymerase chain reaction and direct sequencing.

1990 • 170 citations

Plasma prothrombin during treatment with Dicumarol. II. Demonstration of an abnormal prothrombin fraction.

1968 • 145 citations

The Purification and Properties of an Abnormal Prothrombin Protein Produced by Dicumarol-treated Cows

1972 • 141 citations

Tissue-specific transcription of the mouse alpha-fetoprotein gene promoter is dependent on HNF-1.

1989 • 130 citations

Molecular basis of hemophilia B: a defective enzyme due to an unprocessed propeptide is caused by a point mutation in the factor IX precursor.

1986 • 129 citations

Plasma Prothrombin during Treatment with Dicumarol

1968 • 126 citations

Propeptide of human protein C is necessary for .gamma.-carboxylation

1987 • 121 citations

Vitamin K-dependent carboxylase. Control of enzyme activity by the “propeptide” region of factor X.

1987 • 119 citations

Synthesis of clotting factors by the isolated perfused rat liver.

1966 • 105 citations

Production of abnormal prothrombin (des-γ-carboxy prothrombin) by hepatocellular carcinoma

1987 • 98 citations

Metal binding properties of gamma-carboxyglutamic acid. Implications for the vitamin K-dependent blood coagulation proteins.

1978 • 97 citations

Immunoassays of human prothrombin species which correlate with functional coagulant activities.

1983 • 77 citations

SERUM α1-FETOPROTEIN IN PATIENTS WITH LIVER DISEASE

1969 • 77 citations

Interaction of a hepatoma-specific nuclear factor with transcription-regulatory sequences of the human alpha-fetoprotein and albumin genes.

1988 • 72 citations

Production of HBs-antigen by two new human hepatoma cell lines and its enhancement by dexamethasone.

1981 • 69 citations

Factor IX San Dimas

1989 • 57 citations

Cellular site for prothrombin synthesis

1960 • 55 citations

Isolation and characterization of a hepatoma-associated abnormal (des-gamma-carboxy)prothrombin.

1989 • 52 citations

Effect of propeptide mutations on post-translational processing of factor IX. Evidence that beta-hydroxylation and gamma-carboxylation are independent events.

1987 • 51 citations

Appearance of viral RNA transcripts in the early stage of duck hepatitis B virus infection

1986 • 46 citations

Vitamin K-dependent carboxylase: possible role of the substrate "propeptide" as an intracellular recognition site.

1987 • 42 citations

Abnormal prothrombin in the plasma of rats carrying hepatic tumors

1987 • 34 citations

Factor IX Kawachinagano: impaired function of the Gla‐domain caused by attached propeptide region due to substitution of arginine by glutamine at position −4

1989 • 29 citations

Studies on a Subcellular System for Vitamin K- Dependent Carboxylation

1979 • 22 citations

Measurement of prothrombin-related antigen, des-gamma-carboxy prothrombin and vitamin K in human liver tissues.

1990 • 4 citations