GPI anchoring leads to sphingolipid-dependent retention of endocytosed proteins in the recycling endosomal compartment

Regulation of Renal Organic Anion Transporter 3 (SLC22A8) Expression and Function by the Integrity of Lipid Raft Domains and their Associated Cytoskeleton

2013 • 2,950 citations

FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES

1998 • 2,942 citations

Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface

1992 • 2,905 citations

Endocytosis

1997 • 1,263 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

GPI-anchored proteins are organized in submicron domains at the cell surface

1998 • 1,207 citations

Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme

1991 • 1,094 citations

Sphingolipid–Cholesterol Rafts Diffuse as Small Entities in the Plasma Membrane of Mammalian Cells

2000 • 987 citations

Structure and Origin of Ordered Lipid Domains in Biological Membranes

1998 • 962 citations

The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes

1993 • 896 citations

Caveolae, DIGs, and the dynamics of sphingolipid—cholesterol microdomains

1997 • 783 citations

Membrane transport in the endocytic pathway

1995 • 644 citations

Properties of lipid microdomains in a muscle cell membrane visualized by single molecule microscopy

2000 • 572 citations

Microdomains of GPI-anchored proteins in living cells revealed by crosslinking

1998 • 555 citations

Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform [published erratum appears in J Cell Biol 1995 Jul;130(2):501]

1995 • 541 citations

Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process.

1993 • 516 citations

The differential miscibility of lipids as the basis for the formation of functional membrane rafts

1998 • 512 citations

Sequestration of GPI-Anchored Proteins in Caveolae Triggered by Cross-Linking

1994 • 505 citations

Distribution of a Glycosylphosphatidylinositol-anchored Protein at the Apical Surface of MDCK Cells Examined at a Resolution of &lt;100 Å Using Imaging Fluorescence Resonance Energy Transfer

1998 • 452 citations

High-Resolution FRET Microscopy of Cholera Toxin B-Subunit and GPI-anchored Proteins in Cell Plasma Membranes

2000 • 427 citations

Looking at lipid rafts?

1999 • 406 citations

Post-Golgi biosynthetic trafficking

1997 • 373 citations

Regulation of Protein Secretion Through Controlled Aggregation in the Endoplasmic Reticulum

2000 • 345 citations

Cholesterol-dependent retention of GPI-anchored proteins in endosomes

1998 • 313 citations

Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide.

1993 • 305 citations

Insolubility and redistribution of GPI-anchored proteins at the cell surface after detergent treatment.

1995 • 294 citations

Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles.

1988 • 285 citations

The Emp24 Complex Recruits a Specific Cargo Molecule into Endoplasmic Reticulum–Derived Vesicles

2000 • 257 citations

Preparation of the active isomer of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol, inhibitor of murine glucocerebroside synthetase

1987 • 254 citations

N-Glycans Mediate the Apical Sorting of a Gpi-Anchored, Raft-Associated Protein in Madin-Darby Canine Kidney Cells

1999 • 247 citations

Glycosphingolipid-enriched, detergent-insoluble complexes in protein sorting in epithelial cells

1993 • 246 citations

Lipid microdomains in cell surface membranes

1997 • 245 citations

Lowering the cholesterol content of MA104 cells inhibits receptor-mediated transport of folate.

1992 • 233 citations

Hierarchy of mechanisms involved in generating Na/K-ATPase polarity in MDCK epithelial cells.

1995 • 211 citations

Endosome acidification and receptor trafficking: bafilomycin A1 slows receptor externalization by a mechanism involving the receptor's internalization motif.

1993 • 205 citations

Lipid domains in model and biological membranes

1994 • 199 citations

Fumonisin B1-induced Sphingolipid Depletion Inhibits Vitamin Uptake via the Glycosylphosphatidylinositol-anchored Folate Receptor

1997 • 193 citations

Mutations in the Middle of the Transmembrane Domain Reverse the Polarity of Transport of the Influenza Virus Hemagglutinin in MDCK Epithelial Cells

1998 • 192 citations

Endocytosis of GPI-linked membrane folate receptor-alpha.

1996 • 188 citations

Mammalian Cell Mutants Resistant to a Sphingomyelin-directed Cytolysin

1998 • 181 citations

Common signals control low density lipoprotein receptor sorting in endosomes and the Golgi complex of MDCK cells

1993 • 167 citations

High Cell Sensitivity toHelicobacter pyloriVacA Toxin Depends on a GPI-anchored Protein and is not Blocked by Inhibition of the Clathrin-mediated Pathway of Endocytosis

2000 • 159 citations

Oligomerized transferrin receptors are selectively retained by a lumenal sorting signal in a long-lived endocytic recycling compartment.

1995 • 153 citations

Endocytosis of glycophospholipid-anchored and transmembrane forms of CD4 by different endocytic pathways.

1992 • 129 citations

The folate receptor works in tandem with a probenecid-sensitive carrier in MA104 cells in vitro.

1991 • 122 citations

Ceramide As a Modulator of Endocytosis

1995 • 121 citations

Detergent-insoluble GPI–anchored Proteins Are Apically Sorted in Fischer Rat Thyroid Cells, but Interference with Cholesterol or Sphingolipids Differentially Affects Detergent Insolubility and Apical Sorting

2000 • 118 citations

Signal Transduction via Glycosyl Phosphatidylinositol-anchored Proteins in T Cells Is Inhibited by Lowering Cellular Cholesterol

1997 • 117 citations

Emerging functional roles for the glycosyl-phosphatidylinositol membrane protein anchor

1990 • 110 citations

Inhibition of experimental metastasis of murine Lewis lung carcinoma by an inhibitor of glucosylceramide synthase and its possible mechanism of action.

1990 • 99 citations

Reduction of Sphingomyelin Level without Accumulation of Ceramide in Chinese Hamster Ovary Cells Affects Detergent-resistant Membrane Domains and Enhances Cellular Cholesterol Efflux to Methyl-β-cyclodextrin

2000 • 96 citations

A ceramide analog inhibits T cell proliferative response through inhibition of glycosphingolipid synthesis and enhancement of N,N-dimethylsphingosine synthesis

1990 • 92 citations

The End2 mutation in CHO cells slows the exit of transferrin receptors from the recycling compartment but bulk membrane recycling is unaffected

1993 • 86 citations

Endocytic mechanisms responsible for uptake of GPI-linked diphtheria toxin receptor

1999 • 81 citations

Traffic, polarity, and detergent solubility of a glycosylphosphatidylinositol-anchored protein after LDL-deprivation of MDCK cells.

1996 • 81 citations

Folate receptors targeted to clathrin-coated pits cannot regulate vitamin uptake.

1995 • 78 citations

Lipid composition of PC12 pheochromocytoma cells: characterization of globoside as a major neutral glycolipid

1988 • 70 citations

What Can GPI Do for You?

1994 • 66 citations

Cell Surface Dynamics of GPI-Anchored Proteins

1997 • 58 citations

Internalization of glycosyl‐phosphatidylinositol (GPI)‐anchored lymphocyte proteins II. GPI‐anchored and transmembrane molecules internalize through distinct pathways

1992 • 51 citations

Signal Transduction Via GPI-Anchored Membrane Proteins

1997 • 50 citations

Synthesis and biological evaluation of a fluorescent analog of folic acid

1991 • 32 citations

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