Mice deficient for prion protein exhibit normal neuronal excitability and synaptic transmission in the hippocampus.

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

1993 • 2,237 citations

Mice devoid of PrP are resistant to scrapie

1993 • 2,058 citations

Molecular Biology of Prion Diseases

1991 • 1,978 citations

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

1992 • 1,632 citations

Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype

1995 • 1,457 citations

Giant synaptic potentials in immature rat CA3 hippocampal neurones.

1989 • 1,302 citations

Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor

1995 • 1,016 citations

Whole cell recording from neurons in slices of reptilian and mammalian cerebral cortex

1989 • 977 citations

Unconventional Viruses and the Origin and Disappearance of Kuru

1977 • 897 citations

Prion protein is necessary for normal synaptic function

1994 • 802 citations

The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive.

1991 • 627 citations

The new mouse genetics: Altering the genome by gene targeting

1989 • 608 citations

Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells.

1990 • 510 citations

Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies.

1993 • 461 citations

Changes in the localization of brain prion proteins during scrapie infection

1987 • 268 citations

Targeted mutation of the Hprt gene in mouse embryonic stem cells.

1988 • 226 citations

Immunoaffinity purification and neutralization of scrapie prion infectivity.

1988 • 205 citations

Development of GABA‐mediated, chloride‐dependent inhibition in CA1 pyramidal neurones of immature rat hippocampal slices.

1991 • 193 citations

A simple chamber for recording from submerged brain slices

1981 • 190 citations

BIOLOGY AND GENETICS OF PRION DISEASES

1994 • 170 citations

Prion Diseases and Neurodegeneration

1994 • 163 citations

Inhibitory post‐synaptic currents in rat hippocampal CA1 neurones.

1984 • 155 citations

Rescue of neurophysiological phenotype seen in PrP null mice by transgene encoding human prion protein

1995 • 146 citations

Attempts to restore scrapie prion infectivity after exposure to protein denaturants.

1993 • 130 citations

Rectification of single GABA-gated chloride channels in adult hippocampal neurons

1985 • 124 citations

Patch‐clamp Analysis of Synaptic Transmission to Cerebellar Purkinje Cells of Prion Protein Knockout Mice

1995 • 92 citations

Protein and Molecular Characterization of Hippocampal Protein Kinase C in C57BL/6 and DBA/2 Mice

1995 • 50 citations

Normal development of nerve—muscle synapses in mice lacking the prion protein gene

1992 • 27 citations