Mechanisms of apoptosis-induction by rottlerin: therapeutic implications for B-CLL

CHOP Chemotherapy plus Rituximab Compared with CHOP Alone in Elderly Patients with Diffuse Large-B-Cell Lymphoma

2002 • 5,269 citations

Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal Cancer

2004 • 4,992 citations

Unmutated Ig VH Genes Are Associated With a More Aggressive Form of Chronic Lymphocytic Leukemia

1999 • 2,674 citations

X-linked IAP is a direct inhibitor of cell-death proteases

1997 • 1,961 citations

ZAP-70 Expression as a Surrogate for Immunoglobulin-Variable-Region Mutations in Chronic Lymphocytic Leukemia

2003 • 1,366 citations

Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

1998 • 1,118 citations

Rottlerin, a Novel Protein Kinase Inhibitor

1994 • 839 citations

Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

1996 • 734 citations

Expression of Apoptosis-Regulating Proteins in Chronic Lymphocytic Leukemia: Correlations With In Vitro and In Vivo Chemoresponses

1998 • 656 citations

B-Cell Chronic Lymphocytic Leukemia: A Bird of a Different Feather

1999 • 408 citations

Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor kappa B binding sites.

1991 • 373 citations

BCL-2: Prevention of Apoptosis as a Mechanism of Drug Resistance

1995 • 323 citations

Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro

1996 • 309 citations

Modulation of NF-κB Activity and Apoptosis in Chronic Lymphocytic Leukemia B Cells

2000 • 278 citations

Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia

2000 • 258 citations

Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cδ

2002 • 253 citations

Rottlerin Is a Mitochondrial Uncoupler That Decreases Cellular ATP Levels and Indirectly Blocks Protein Kinase Cδ Tyrosine Phosphorylation

2001 • 225 citations

Role of the microenvironment in chronic lymphocytic leukaemia

2003 • 202 citations

Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia

2000 • 193 citations

Mammalian TOR Controls One of Two Kinase Pathways Acting upon nPKCδ and nPKCε

1999 • 182 citations

Thrombin Stimulation of Vascular Adhesion Molecule-1 in Endothelial Cells Is Mediated by Protein Kinase C (PKC)-δ-NF-κB and PKC-ζ-GATA Signaling Pathways

2003 • 110 citations

Induction of cIAP-2 in Human Colon Cancer Cells through PKCδ/NF-κB

2003 • 102 citations

Regulation of Airway Epithelial Cell NF-κB-Dependent Gene Expression by Protein Kinase Cδ

2003 • 102 citations

B-Cell Receptor- and Phorbol Ester-Induced NF-κB and c-Jun N-Terminal Kinase Activation in B Cells Requires Novel Protein Kinase C's

2001 • 88 citations

Identification of Serine 643 of Protein Kinase C-δ as an Important Autophosphorylation Site for Its Enzymatic Activity

1997 • 76 citations

Transcriptional and translational control of Mcl-1 during apoptosis

2003 • 72 citations

Involvement of protein kinase C in the transcriptional regulation of 12-O-tetradecanoylphorbol-13-acetate-inducible genes modulated by AP-1 or non-AP-1 transacting factors

1994 • 39 citations

Quantitating adenylate nucleotides in diverse organisms

2005 • 33 citations

Cycling B-CLL cells are highly susceptible to inhibition of the proteasome

2003 • 28 citations

Role of Protein Kinase Cδ in Endothelin-Induced Type I Collagen Expression in Cardiac Myofibroblasts Isolated from the Site of Myocardial Infarction

2004 • 27 citations

Fludarabine Inhibits DNA Replication: A Rationale for Its Use in the Treatment of Acute Leukemias

1994 • 24 citations

Verapamil preferentially potentiates in‐vitro cytotoxicity of vincristine on malignant lymphoid cells

1992 • 3 citations