Cycling B-CLL cells are highly susceptible to inhibition of the proteasome

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1999 • 1,872 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

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1999 • 1,447 citations

Cellular stress response and apoptosis in cancer therapy

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bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia

1993 • 660 citations

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1998 • 656 citations

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2000 • 604 citations

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1998 • 597 citations

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1997 • 494 citations

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1999 • 461 citations

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2000 • 439 citations

Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia

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Proteasome Inhibitors Activate Stress Kinases and Induce Hsp72

1998 • 304 citations

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1996 • 292 citations

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1996 • 278 citations

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1998 • 277 citations

Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria

2000 • 269 citations

Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria

2000 • 236 citations

Cleavage of Bax Enhances Its Cell Death Function

2000 • 217 citations

Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells

2000 • 216 citations

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1995 • 198 citations

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2000 • 195 citations

Rapid Deubiquitination of Nucleosomal Histones in Human Tumor Cells Caused by Proteasome Inhibitors and Stress Response Inducers: Effects on Replication, Transcription, Translation, and the Cellular Stress Response

1997 • 170 citations

Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and relative expression of BCL-2 and BAX.

1996 • 165 citations

Inhibition of proteasome function induces programmed cell death in proliferating endothelial cells

2000 • 156 citations

Overexpression of cyclin D2 in chronic B-cell malignancies

1995 • 154 citations

Prognostic Significance of the Cell Cycle Inhibitor p27Kip1 in Chronic B-Cell Lymphocytic Leukemia

1998 • 149 citations

Increased sensitivity of CLL‐derived lymphocytes to apoptotic death activation by the proteasome‐specific inhibitor lactacystin

1999 • 145 citations

Proteasome Inhibitors Induce Apoptosis in Glucocorticoid-Resistant Chronic Lymphocytic Leukemic Lymphocytes

1998 • 136 citations

Prognostic Significance of the Cell Cycle Inhibitor p27Kip1 in Chronic B-Cell Lymphocytic Leukemia

1998 • 126 citations

Proteasomes Modulate Balance Among Proapoptotic and Antiapoptotic Bcl-2 Family Members and Compromise Functioning of the Electron Transport Chain in Leukemic Cells

2001 • 122 citations

Cell cycle progression of chronic lymphocytic leukemia cells is controlled by cyclin D2, cyclin D3, cyclin-dependent kinase (cdk) 4 and the cdk inhibitor p27

2002 • 108 citations

Ubiquitin-mediated proteolysis of vertebrate G1- and S-phase regulators

2001 • 102 citations

Deregulation of the ubiquitin system and p53 proteolysis modify the apoptotic response in B-CLL lymphocytes

2000 • 98 citations

p27Kip1 accumulation by inhibition of proteasome function induces apoptosis in oral squamous cell carcinoma cells.

2000 • 98 citations

Immunostimulatory CpG-oligonucleotides induce functional high affinity IL-2 receptors on B-CLL cells

2000 • 97 citations

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Proteasome Activation Occurs at an Early, Premitochondrial Step of Thymocyte Apoptosis

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Proteasome regulation of activation-induced T cell death

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Proteasome inhibitor-induced apoptosis of B-chronic lymphocytic leukaemia cells involves cytochrome c release and caspase activation, accompanied by formation of an ∼700 kDa Apaf-1 containing apoptosome complex

2001 • 82 citations

High expression of CD23 in the proliferation centers of chronic lymphocytic leukemia in lymph nodes and spleen

1999 • 76 citations

Inhibition of ubiquitin-proteasome pathway activates a caspase-3-like protease and induces Bcl-2 cleavage in human M-07e leukaemic cells

1999 • 75 citations

Apoptosis and cancer: Strategies for integrating programmed cell death

2000 • 73 citations

Bax expression correlates with cellular drug sensitivity to doxorubicin, cyclophosphamide and chlorambucil but not fludarabine, cladribine or corticosteroids in B cell chronic lymphocytic leukemia

2002 • 66 citations

Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or γ radiation

2001 • 65 citations

Chemosensitivity of B cell chronic lymphocytic leukemia and correlated expression of proteins regulating apoptosis, cell cycle and DNA repair

2000 • 62 citations

Cleavage of p21 by Proteinase-3, a Myeloid-specific Serine Protease, Potentiates Cell Proliferation

2002 • 47 citations

Caspases influence the mode but not the extent of cell death induced by purine analogues in chronic lymphocytic leukaemia

2000 • 31 citations

Proteasome inhibitors

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1995 • 17 citations