Lowering cholesterol, 1988. Rationale, mechanisms, and means.

A Receptor-Mediated Pathway for Cholesterol Homeostasis

1986 • 5,638 citations

The Pathogenesis of Atherosclerosis — An Update

1986 • 4,951 citations

Helsinki Heart Study: Primary-Prevention Trial with Gemfibrozil in Middle-Aged Men with Dyslipidemia

1987 • 3,889 citations

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

1977 • 2,481 citations

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

1979 • 2,458 citations

Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults

1988 • 2,276 citations

Apolipoprotein E polymorphism and atherosclerosis.

1988 • 2,007 citations

Fifteen year mortality in Coronary Drug Project patients: Long-term benefit with niacin

1986 • 1,857 citations

Beneficial Effects of Combined Colestipol-Niacin Therapy on Coronary Atherosclerosis and Coronary Venous Bypass Grafts

1987 • 1,651 citations

Is Relationship Between Serum Cholesterol and Risk of Premature Death From Coronary Heart Disease Continuous and Graded?

1986 • 1,248 citations

Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.

1987 • 1,051 citations

Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia.

1987 • 885 citations

Lowering Blood Cholesterol to Prevent Heart Disease

1985 • 667 citations

Probucol inhibits oxidative modification of low density lipoprotein.

1986 • 633 citations

Familial defective apolipoprotein B-100: low density lipoproteins with abnormal receptor binding.

1987 • 476 citations

[1] Introduction to the plasma lipoproteins

1986 • 420 citations

Deletion in Cysteine-Rich Region of LDL Receptor Impedes Transport to Cell Surface in WHHL Rabbit

1986 • 335 citations

Hepatic catabolism of rat and human lipoproteins in rats treated with 17 alpha-ethinyl estradiol.

1979 • 322 citations

Dietary saturated triacylglycerols suppress hepatic low density lipoprotein receptor activity in the hamster.

1985 • 318 citations

Lipoproteins and atherosclerosis. A look back and a look ahead.

1983 • 315 citations

Effects of probucol on xanthomata regression in familial hypercholesterolemia

1986 • 232 citations

Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts

1987 • 231 citations

Lovastatin (Mevinolin) in the Treatment of Heterozygous Familial Hypercholesterolemia

1987 • 215 citations

Influence of mevinolin on metabolism of low density lipoproteins in primary moderate hypercholesterolemia.

1985 • 210 citations

Reduction of Serum Cholesterol in Heterozygous Patients with Familial Hypercholesterolemia

1983 • 201 citations

Normalization of Low-Density-Lipoprotein Levels in Heterozygous Familial Hypercholesterolemia with a Combined Drug Regimen

1981 • 197 citations

New developments in lipid-lowering therapy: the role of inhibitors of hydroxymethylglutaryl-coenzyme A reductase.

1987 • 196 citations

Apolipoprotein B gene variants are involved in the determination of serum cholesterol levels: a study in normo- and hypelipidaemic individuals

1987 • 166 citations

Therapeutic Response to Lovastatin (Mevinolin) in Nonfamilial Hypercholesterolemia

1986 • 160 citations

Total cholesterol and high density lipoprotein cholesterol levels in populations differing in fat and carbohydrate intake.

1987 • 150 citations

The long term effects of dietary cholesterol upon the plasma lipids, lipoproteins, cholesterol absorption, and the sterol balance in man: the demonstration of feedback inhibition of cholesterol biosynthesis and increased bile acid excretion

1980 • 148 citations

Mevinolin Plus Colestipol in Therapy for Severe Heterozygous Familial Hypercholesterolemia

1984 • 132 citations

Cholesterol Transport Between Cells and Body Fluids: Role of Plasma Lipoproteins and the Plasma Cholesterol Esterification System

1982 • 130 citations

Levels and interrelationships of serum and lipoprotein cholesterol and triglycerides. Association with adiposity and the consumption of ethanol, tobacco, and beverages containing caffeine.

1981 • 126 citations

Review of lipid-lowering clinical trials in relation to observational epidemiologic studies.

1987 • 126 citations

Uptake of canine beta-very low density lipoproteins by mouse peritoneal macrophages is mediated by a low density lipoprotein receptor.

1986 • 123 citations

Overexpression of Low Density Lipoprotein (LDL) Receptor Eliminates LDL from Plasma in Transgenic Mice

1988 • 121 citations

Regulation of Hepatic Lipoprotein Receptors in the Dog. RAPID REGULATION OF APOLIPOPROTEIN B,E RECEPTORS, BUT NOT OF APOLIPOPROTEIN E RECEPTORS, BY INTESTINAL LIPOPROTEINS AND BILE ACIDS

1983 • 120 citations

Prevention of coronary heart disease--propaganda, promises, problems, and prospects.

1986 • 111 citations

Cholestyramine-induced changes in low density lipoprotein composition and metabolism. I. Studies in the guinea pig.

1985 • 110 citations

Influence of Combined Therapy with Mevinolin and Interruption of Bile-Acid Reabsorption on Low Density Lipoproteins in Heterozygous Familial Hypercholesterolemia

1985 • 108 citations

Increased coronary mortality in relatives of hypercholesterolemic school children: the Muscatine study.

1979 • 103 citations

Drugs and Lipid Metabolism

1973 • 102 citations

Complementarity of Colestipol, Niacin, and Lovastatin in Treatment of Severe Familial Hypercholesterolemia

1987 • 87 citations

Treatment of homozygous familial hypercholesterolaemia with probucol.

1982 • 83 citations

George Lyman Duff memorial lecture. Role of the liver in atherosclerosis.

1985 • 81 citations

Secretion of lipoproteins from the liver of normal and Watanabe heritable hyperlipidemic rabbits.

1983 • 81 citations

Functional Activities of Hepatic Lipoprotein Receptors

1986 • 76 citations

Treatment of Hypercholesterolemia

1982 • 73 citations

Treatment of Hypertriglyceridemia

1984 • 70 citations

Coronary artery atherosclerosis revisited in Korean war combat casualties.

1987 • 61 citations

Effect of low density lipoprotein receptor deficiency on the metabolism of apolipoprotein B-100 in blood plasma. Kinetic studies in normal and Watanabe heritable hyperlipidemic rabbits.

1987 • 56 citations

Role of apolipoprotein E in lipoprotein metabolism

1987 • 42 citations

Mevinolin stimulates receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.

1983 • 40 citations

The role of the liver in atherosclerosis.

1950 • 24 citations

Longitudinal serum lipoprotein changes in white males during adolescence: The Bogalusa Heart Study

1985 • 22 citations

Comparison of clofibrate and caloric restriction on kinetics of very low density lipoprotein triglycerides.

1985 • 21 citations

Treatment of Hypercholesterolemia

1986 • 19 citations

Experimental atherosclerosis

1966 • 18 citations

High density lipoprotein alterations induced by bezafibrate in healthy male volunteers

1987 • 15 citations

High risk versus public health strategies in primary prevention of coronary heart disease

1987 • 14 citations

Functional Activities of Hepatic Lipoprotein Receptors

1986 • 9 citations

Dietary regulation of plasma lipoprotein metabolism in humans.

1983 • 5 citations