Tissue-specific posttranslational processing of pre-prosomatostatin encoded by a metallothionein-somatostatin fusion gene in transgenic mice

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

1973 • 3,509 citations

Ribonucleic acid isolated by cesium chloride centrifugation

1974 • 2,263 citations

Dramatic growth of mice that develop from eggs microinjected with metallothionein–growth hormone fusion genes

1982 • 1,338 citations

Metallothionein-Human GH Fusion Genes Stimulate Growth of Mice

1983 • 699 citations

Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs

1981 • 681 citations

Transcriptional regulation of the mouse metallothionein-I gene by heavy metals.

1981 • 601 citations

Human β-globin pre-mRNA synthesized in vitro is accurately spliced in xenopus oocyte nuclei

1983 • 500 citations

Somatostatin in Hypothalamus, Extrahypothalamic Brain, and Peripheral Tissues of the Rat*

1978 • 474 citations

Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring

1982 • 379 citations

[NEUROENDOCRINE CONTROL OF THE THYROTROPIN SECRETION].

1964 • 378 citations

Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation

1983 • 329 citations

The Human Growth Hormone Gene Family: Nucleotide Sequences Show Recent Divergence and Predict a New Polypeptide Hormone

1982 • 312 citations

Structure of mouse metallothionein-I gene and its mRNA

1981 • 301 citations

Regulation of metallothionein–thymidine kinase fusion plasmids injected into mouse eggs

1982 • 283 citations

Human somatostatin I: sequence of the cDNA.

1982 • 279 citations

The mouse metallothionein-I gene is transcriptionally regulated by cadmium following transfection into human or mouse cells

1982 • 265 citations

Physiological role of somatostatin in the control of growth hormone and thyrotropin secretion

1976 • 241 citations

Rat pre-prosomatostatin. Structure and processing by microsomal membranes.

1983 • 218 citations

Multiple Forms of Immunoreactive Somatostatin: Comparison of Distribution in Neural and Nonneural Tissues and Portal Plasma of the Rat*

1981 • 189 citations

Transmission distortion and mosaicism in an unusual transgenic mouse pedigree

1984 • 169 citations

Prenatal lethalities in mice homozygous for human growth hormone gene sequences integrated in the germ line

1983 • 161 citations

Presence of somatostatin-28-(1-12) in hypothalamus and pancreas.

1982 • 152 citations

Seven peptides derived from pro-somatostatin in rat brain

1982 • 146 citations

Cloning and characterization of a mRNA-encoding rat preprosomatostatin.

1983 • 139 citations

Formation of the 3′ end of histone mRNA by post-transcriptional processing

1984 • 129 citations

Expression of the chicken transferrin gene in transgenic mice

1983 • 126 citations

High biological activity of the synthetic replicates of somatostatin-28 and somatostatin-25

1981 • 118 citations

Synthesis and biological actions of prosomatostatin.

1980 • 100 citations

Pituitary hormone releasing or inhibiting activity of metal ions present in hypothalamic extracts

1973 • 95 citations

Secretion of human parathyroid hormone from rat pituitary cells infected with a recombinant retrovirus encoding preproparathyroid hormone.

1984 • 92 citations

Circulating Somatostatin Acts on the Islets of Langerhans by Way of a Somatostatin-Poor Compartment

1982 • 84 citations

PROLONGED SOMATOSTATIN PRETREATMENT DESENSITIZES SOMATOSTATIN'S INHIBITION OF RECEPTOR-MEDIATED RELEASE OF ADRENOCORTICOTROPIN HORMONE AND SENSITIZES ADENYLATE CYCLASE

1983 • 75 citations

Heterogeneity of Somatostatin-Like Peptides in Rat Brain, Pancreas, and Gastrointestinal Tract*

1981 • 70 citations

A Sensitive Radioimmunoassay for Immunoreactive Somatostatin in Extracted Plasma: Measurement and Characterization of Portal and Peripheral Plasma in the Rat*

1980 • 63 citations

Effects of Somatostatin-14 and Somatostatin-28 on Bombesin-Stimulated Release of Gastrin, Insulin, and Glucagon in the Dog*

1981 • 56 citations

Somatostatin and diabetes

1981 • 53 citations

Five Cases of Somatostatinoma: Clinical Heterogeneity and Diagnostic Usefulness of Basal and Tolbutamide-Induced Hypersomatostatinemia*

1983 • 53 citations

Neuropeptides derived from prosomatostatin that do not contain the somatostatin-14 sequence

1984 • 43 citations

Structure of Somatostatin Isolated from Bovine Retina

1983 • 27 citations

Nonradial m-mode changes in the 53 Persei variable 22 Orionis

1980 • 3 citations