cAMP-dependent Protein Kinase

Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.

1995 • 2,534 citations

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification ¹

1995 • 2,199 citations

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1998 • 1,931 citations

An Adenosine 3′,5′-Monophosphate-dependant Protein Kinase from Rabbit Skeletal Muscle

1968 • 1,423 citations

Active and Inactive Protein Kinases: Structural Basis for Regulation

1996 • 1,361 citations

Identification of a signal for rapid export of proteins from the nucleus

1995 • 1,186 citations

cAMP-DEPENDENT PROTEIN KINASE: FRAMEWORK FOR A DIVERSE FAMILY OF REGULATORY ENZYMES

1990 • 1,121 citations

Mutations of the gene encoding the protein kinase A type I-α regulatory subunit in patients with the Carney complex

2000 • 1,109 citations

Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

1991 • 949 citations

Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with magnesium-ATP and peptide inhibitor

1993 • 593 citations

Kinetic and Catalytic Mechanisms of Protein Kinases

2001 • 584 citations

Peptides and Protein Phosphorylation

2018 • 525 citations

Structure and Function of Cyclic Nucleotide-Dependent Protein Kinases

1994 • 442 citations

Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A

1996 • 406 citations

Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).

1993 • 399 citations

n-Tetradecanoyl is the NH2-terminal blocking group of the catalytic subunit of cyclic AMP-dependent protein kinase from bovine cardiac muscle.

1982 • 395 citations

Dynamics of cAMP-Dependent Protein Kinase

2001 • 385 citations

Regulatory Subunit Of Protein Kinase A: Structure of Deletion Mutant with cAMP Binding Domains

1995 • 381 citations

Compartmentation of G Protein-Coupled Signaling Pathways in Cardiac Myocytes

2001 • 376 citations

AKAP Mediated Signal Transduction

2002 • 343 citations

Structural Framework for the Protein Kinase Family

1992 • 333 citations

Crystal structures of the myristylated catalytic subunit of cAMP‐dependent protein kinase reveal open and closed conformations

1993 • 284 citations

Pyramidal Cells of the Frontal Lobe: All the More Spinous to Think With

2000 • 283 citations

Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase.

1986 • 275 citations

Molecular Cloning of a Tissue-Specific Protein Kinase (C_γ) from Human Testis—Representing a Third Isoform for the Catalytic Subunit of cAMP-Dependent Protein Kinase

1990 • 232 citations

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase

1998 • 230 citations

The Native Rat Olfactory Cyclic Nucleotide-Gated Channel Is Composed of Three Distinct Subunits

1999 • 222 citations

Compensatory Regulation of RIα Protein Levels in Protein Kinase A Mutant Mice

1997 • 220 citations

Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase

2002 • 207 citations

A cloned bovine cDNA encodes an alternate form of the catalytic subunit of cAMP-dependent protein kinase.

1986 • 206 citations

A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes

2001 • 203 citations

A template for the protein kinase family

1993 • 196 citations

Amino acid sequence of the catalytic subunit of bovine type II adenosine cyclic 3',5'-phosphate-dependent protein kinase

1983 • 185 citations

High Ethanol Consumption and Low Sensitivity to Ethanol-Induced Sedation in Protein Kinase A-Mutant Mice

2000 • 177 citations

Sequence of two phosphorylated sites in the catalytic subunit of bovine cardiac muscle adenosine 3‘:5‘-monophosphate-dependent protein kinase.

1979 • 145 citations

Affinity labeling of the nucleotide binding site of the catalytic subunit of cAMP-dependent protein kinase using p-fluorosulfonyl-[14C]benzoyl 5'-adenosine. Identification of a modified lysine residue.

1979 • 144 citations

Energetic limits of phosphotransfer in the catalytic subunit of cAMP-dependent protein kinase as measured by viscosity experiments

1992 • 142 citations

Phosphorylation Modulates Catalytic Function and Regulation in the cAMP-Dependent Protein Kinase

1995 • 132 citations

Classification and Phylogenetic Analysis of the cAMP-Dependent Protein Kinase Regulatory Subunit Family

2002 • 123 citations

A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility

1997 • 119 citations

Holoenzymes of cAMP-dependent protein kinase containing the neural form of type I regulatory subunit have an increased sensitivity to cyclic nucleotides.

1990 • 106 citations

Amide H/2H Exchange Reveals Communication Between the cAMP and Catalytic Subunit-binding Sites in the RIα Subunit of Protein Kinase A

2002 • 95 citations

A point mutation abolishes binding of cAMP to site A in the regulatory subunit of cAMP-dependent protein kinase.

1988 • 91 citations

Dissection of the Nucleotide and Metal−Phosphate Binding Sites in cAMP-Dependent Protein Kinase

1999 • 91 citations

Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli

1997 • 85 citations

Physiological Phosphorylation of Protein Kinase A at Thr-197 Is by a Protein Kinase A Kinase

1998 • 80 citations

Two Novel Brain-specific Splice Variants of the Murine Cβ Gene of cAMP-dependent Protein Kinase

1997 • 78 citations

A conserved helix motif complements the protein kinase core.

1993 • 71 citations

Is There a Catalytic Base in the Active Site of cAMP-Dependent Protein Kinase?

1997 • 70 citations

Identification of aspartate-184 as an essential residue in the catalytic subunit of cAMP-dependent protein kinase

1988 • 70 citations

Serine-53 at the Tip of the Glycine-Rich Loop of cAMP-Dependent Protein Kinase: Role in Catalysis, P-Site Specificity, and Interaction with Inhibitors

2000 • 67 citations

Dissecting cAMP Binding Domain A in the RIα Subunit of cAMP-dependent Protein Kinase

1998 • 65 citations

Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase.

1992 • 59 citations

Snapping of the Carboxyl Terminal Tail of the Catalytic Subunit of PKA onto Its Core: Characterization of the Sites by Mutagenesis

2000 • 57 citations

Isoform-specific Differences between the Type Iα and IIα Cyclic AMP-dependent Protein Kinase Anchoring Domains Revealed by Solution NMR

2000 • 54 citations

Evidence for an internal entropy contribution to phosphoryl transfer: a study of domain closure, backbone flexibility, and the catalytic cycle of cAMP-dependent protein kinase

2002 • 48 citations

Phosphorylation of peptide substrates for the catalytic subunit of cAMP-dependent protein kinase.

1993 • 47 citations

Consequences of cAMP and Catalytic-Subunit Binding on the Flexibility of the A-Kinase Regulatory Subunit

2000 • 36 citations

The Unique Catalytic Subunit of Sperm cAMP-dependent Protein Kinase Is the Product of an Alternative Cα mRNA Expressed Specifically in Spermatogenic Cells

2000 • 35 citations

A Structural Model of the Catalytic Subunit-regulatory Subunit Dimeric Complex of the cAMP-dependent Protein Kinase

2002 • 32 citations

Release of [3H]adenosine cyclic 3',5'-phosphate bound to the regulatory moiety of protein kinase I in the presence of magnesium(2+), ATP and the catalytic subunit of the kinase

1983 • 32 citations

Two well‐defined motifs in the cAMP‐dependent protein kinase inhibitor (PKIα) correlate with inhibitory and nuclear export function

1999 • 28 citations

The amino terminus of PKA catalytic subunit—A site for introduction of posttranslation heterogeneities by deamidation: D‐Asp2 and D‐isoAsp2 containing isozymes

2000 • 24 citations

Type IIβ Regulatory Subunit of cAMP-Dependent Protein Kinase: Purification Strategies to Optimize Crystallization

2000 • 18 citations

Protein-Kinase A and Human Disease: The Core of cAMP-Dependent Signaling in Health and Disease

2002 • 2 citations