Is There a Catalytic Base in the Active Site of cAMP-Dependent Protein Kinase?

Enzyme-Catalyzed Phosphoryl Transfer Reactions

1980 • 1,120 citations

Acetylcholinesterase: enzyme structure, reaction dynamics, and virtual transition states

1987 • 1,044 citations

Peptides and Protein Phosphorylation

2018 • 525 citations

Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).

1993 • 399 citations

2.2 Å refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor

1993 • 356 citations

Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactions

1991 • 334 citations

Experiments in physical chemistry

1951 • 248 citations

How do protein kinases discriminate between serine/threonine and tyrosine? Structural insights from the insulin receptor protein‐tyrosine kinase

1995 • 187 citations

Requirements for general acid-base catalysis of complex reactions

1972 • 128 citations

Reactions of pyridines and primary amines with N-phosphorylated pyridines

1984 • 104 citations

Phosphorylation of peptide substrates for the catalytic subunit of cAMP-dependent protein kinase.

1993 • 47 citations

Arrangement and conformations of substrates at the active site of pyruvate kinase from model building studies based on magnetic resonance data.

1976 • 45 citations